Caffeic Acid Induces Apoptosis in Human Cervical Cancer Cells Through the Mitochondrial Pathway

Abstract

Caffeic acid induces apoptosis by inhibiting Bcl-2 activity, leading to release of cytochrome c and subsequent activation of caspase-3, indicating that caffeic acid induces apoptosis via the mitochondrial apoptotic pathway. This also suggests that caffeic acid has a strong anti-tumor effect and may be a promising chemopreventive or chemotherapeutic agent.

Caffeic Acid Induced Apoptosis in MG63 Osteosarcoma Cells Through Activation of Caspases

“…and HeLa cervical cancer cells as well. 11,12 In addition, current results showed percentages of apoptotic cells were significantly increased along with the increment of caffeic acid concentrations, suggesting that caffeic acid induced apoptosis in MG-63 cells in a concentration dependent manner.…”

“…These results are in accordance to previous report, caffeic acid induced translocation of cytochrome c from mitochondria to cytoplasm in HeLa cells. 12 Caspase activation has been recognized as the key to apoptosis, in which the presence of caspase which has been cleaved or activated marking the cells undergo apoptosis. 20 Apoptosis involves diverse cell proteases and response to various apoptotic signals.…”

“…[8][9][10] Besides osteoclastogenesis, caffeic acid was reported to induce apoptosis in SCM1 gastric and HeLa cervical cancer cells. 11,12 Caffeic acid has been reported that when it is combined with all-trans retinoic acid, the inhibitory effect in proliferation activity of SaOS-2 or OSA-01 cells was significantly increased. 13 In addition, caffeic acid merely could reduce cell viability to around 55% in SaOS-2 cells.13 However, to our knowledge, there is not any study in caffeic acid's possible effect to induce apoptosis in osteosarcoma cell.…”

Beneficial Health Effects of Bioactive Compounds Present in Spices and Aromatic Herbs

“…In mice bearing a Caki-I carcinoma, CA retarded tumour growth and suppressed STAT3 phosphorylation, HIF-1a expression, vascularization and STAT3-inducible VEGF gene expression in tumours. Chang et al [61] reported that CA significantly reduced proliferation of cervical cancer cells (HeLa) in a concentration-dependent manner. Morphological evidence of apoptosis, including nuclei fragmentation was clearly observed 24 and 48h after exposure to CA (1mM and 10mM).…”

Caffeic acid product from the highly copper-tolerant plant Elsholtzia splendens post-phytoremediation: its extraction, purification, and identification

“…It possesses both antioxidant and pro-oxidant properties and its pro-oxidant action may be an important mechanism of the anticancer and apoptosis inducingproperties (Maurya and Devasagayam, 2010). Studies indicate that caffeic acid also has a strong antitumor effect and may be a promising chemopreventive or chemotherapeutic agent (Chang et al, 2010). Antioxidants such as caffeic acid can be made to exert pro-oxidant effects in vitro under certain conditions involving the interaction with transition metal ions, thus reducing iron (III) and copper (II) ions to iron (II) and copper (I) ions, respectively.…”