Abstract:Dietary cadmium (Cd) exposure was estimated for adults living in Cd-contaminated areas close to non-ferrous metal plants and compared with dietary Cd exposure in the general Belgian adult population. To evaluate the contamination levels of locally produced food items, 35 fruit samples, 97 vegetable samples, 98 samples of potatoes and 53 samples of meat, liver and kidney of cattle, which had resided for more than 18 months in the contaminated area, were analyzed for Cd. Mean Cd concentrations in fruit and veget… Show more
“…main sources of Cd for their potential hazards for humans and animals [1][2][3]. Liver is a major target organ for showing toxic effects of Cd as a result of accumulation after both acute and chronic poisoning.…”
This study assessed the impact of either cadmium chloride (Cd) or sodium selenite (Se) alone or in combination on male Sprague-Dawley rats. For this purpose, body and liver weights, comet and TUNEL assays, histological analysis and levels of lipid peroxidation and antioxidants in liver were determined in four groups of male Sprague-Dawley rats. The rats were given subcutaneous doses of 1 mg/kg body weight (BW) of either normal saline (control=Ct) or Cd or Se or Cd plus Se (Cd+Se) on alternate days for 4 weeks. The Cd group showed increased DNA damage, apoptosis and hepatic levels of lipid peroxidation and altered histology. Conversely, the antioxidant levels in this group were decreased as compared with the control group. The Se group also showed DNA damage, apoptosis and altered histology and reduced catalase activity, but it was less severe than the Cd group. In the Cd+Se group, ameliorating effects of Se on Cd-induced changes were observed. While the Se was able to curtail the toxic effect of Cd, the Cd or Se alone were genotoxic and cytotoxic for rats receiving a high pharmacological but non-fatal dose of 1 mg/kg BW.
“…main sources of Cd for their potential hazards for humans and animals [1][2][3]. Liver is a major target organ for showing toxic effects of Cd as a result of accumulation after both acute and chronic poisoning.…”
This study assessed the impact of either cadmium chloride (Cd) or sodium selenite (Se) alone or in combination on male Sprague-Dawley rats. For this purpose, body and liver weights, comet and TUNEL assays, histological analysis and levels of lipid peroxidation and antioxidants in liver were determined in four groups of male Sprague-Dawley rats. The rats were given subcutaneous doses of 1 mg/kg body weight (BW) of either normal saline (control=Ct) or Cd or Se or Cd plus Se (Cd+Se) on alternate days for 4 weeks. The Cd group showed increased DNA damage, apoptosis and hepatic levels of lipid peroxidation and altered histology. Conversely, the antioxidant levels in this group were decreased as compared with the control group. The Se group also showed DNA damage, apoptosis and altered histology and reduced catalase activity, but it was less severe than the Cd group. In the Cd+Se group, ameliorating effects of Se on Cd-induced changes were observed. While the Se was able to curtail the toxic effect of Cd, the Cd or Se alone were genotoxic and cytotoxic for rats receiving a high pharmacological but non-fatal dose of 1 mg/kg BW.
“…Significant amounts of Cd and Pb can be transferred from contaminated soil to plants and grass, causing accumulation of these potentially toxic metals in grazing ruminants, particularly in cattle (López Alonso et al 2003; Miranda et al 2005). Accumulation of Cd and Pb in ruminants causes toxic effects in cattle, but also in humans consuming meat and milk contaminated with toxic metals (González-Weller et al 2006; Vromman et al 2008; Cai et al 2009). …”
Concentrations of toxic heavy metals (cadmium (Cd), lead (Pb)) and major nutritional and trace elements (Ca, Mg, P, Cu, Fe, Mn, Se, Zn) were analyzed in the milk of Simmental (n = 20) and Holstein-Friesian (n = 20) cows from an organic farm. Elements were determined using inductively coupled plasma emission atomic spectrometry. The conducted research showed that the milk of Simmental cows was characterized by the more advantageous mineral composition and lower concentration of noxious heavy metals compared to the milk of Holstein-Friesian cows. In the milk of Simmental cows, significantly lower concentrations of Pb and Cd (P < 0.001) and Cu (P < 0.05) and significantly higher concentrations of Fe and Mg (P < 0.05) as well as nonsignificantly higher concentrations of Ca, Mn, and Se were found. In the milk of both breeds, very low Cu concentrations were recorded. The higher-than-recommended concentration of Pb in milk was also found. In the milk of both breeds, the significant positive correlations between concentrations of the following elements were observed: Pb–Cd, Pb–Se, Cd–Se, Cd–Mn, Zn–Cu, Zn–P, Ca–P, Ca–Mg, and Mg–P. The correlations between other elements within each of the analyzed breeds separately were also found.
“…volcanic eruptions and forest fires) (Bandara et al, 2008) and anthropogenic activities (e.g. non-ferrous metals production (Vromman et al, 2008), electroplating (Islamoglu et al, 2006), manufacturing of NieCd batteries and pigments (Fthenakis, 2004), application of phosphate fertilizers (Mortvedt and Osborn, 1982), and burning of fossil fuels (Vouk and Piver, 1983)). Pb also is emitted from natural sources and anthropogenic activities (e.g.…”
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