Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism

Hong, Huihui; Xu, You‐Ping; Xu, Jia; Zhang, Jingjing; Yu, Xiao; Pi, Huifeng; Yang, Lingling; Yu, Zhengping; Wu, Qingqian; Meng, Zhuo-Xian; Ruan, Wei-Shuyi; Ren, Yunzhao; Xu, Shu-Zhen; Lu, Yuan-Qiang; Zhou, Zhou

doi:10.1016/j.envint.2021.106406

Cited by 87 publications

(40 citation statements)

References 57 publications

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“… 31 and Anetor et al . 31 , 32 However, it is inconsistent or even contrary to our initial assumption and the findings of other reports 15 , 33 , 34 , 35 , due to two possible reasons. First, when humans or animals are exposed to low Cd concentrations for a short time, the secretory function of pancreatic islet cells is enhanced, resulting in low blood sugar.…”

Section: Discussioncontrasting

confidence: 99%

“…The present results showed that BCd was negatively correlated with diabetes mellitus prevalence, IFG rate and FBG levels. This finding is consistent with those of Nakamura et al 31 and Anetor et al 32 However, it is inconsistent or even contrary to our initial assumption and the findings of other reports 15,[33][34][35] , due to two possible reasons. First, when humans or animals are exposed to low Cd concentrations for a short time, the secretory function of pancreatic islet cells is enhanced, resulting in low blood sugar.…”

Section: Discussionsupporting

confidence: 81%

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Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Zhang

Yin

Zhu

et al. 2022

J of Diabetes Invest

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Aims/Introduction: Metals play an important role in diabetes mellitus. This crosssectional study aimed to evaluate the overall, individual and interactive effects of multimetal exposure on the prevalence of diabetes mellitus, impaired fasting glucose (IFG) rate and fasting blood glucose (FBG) levels. Materials and Methods:The FBG levels of a study population from a cadmium (Cd)polluted area (n = 250) and an unpolluted area (n = 204), and the metal levels, including magnesium, calcium (Ca), iron (Fe), zinc (Zn), arsenic (As), Cd, copper and lead (Pb) in blood and urine were detected. The study population was divided into a normal fasting glucose group, an IFG group and a diabetes mellitus group on the basis of FBG levels. Results: The IFG rate and diabetes mellitus prevalence were negatively associated with blood Cd and urine Zn levels (IFG rate: odds ratio [OR] 0.780, 95% confidence interval [CI] 0.655-0.928; OR 0.622, 95% CI 0.465-0.831. Diabetes mellitus prevalence: OR 0.506, 95% CI 0.288-0.888; OR 0.609, 95% CI 0.395-0.939), the IFG rate was positively associated with urine Fe levels (OR 1.876, 95% CI 1.290-2.778), and diabetes mellitus prevalence was positively associated with urine Pb and blood Fe levels (OR 1.185, 95% CI 1.022-1.376; OR 1.008, 95% CI 1.001-1.014). A linear negative correlation was observed between FBG levels and blood Cd, and non-linear inverted U-shaped associations were found between FBG levels and Zn, Pb and copper in urine. Conclusions: This research suggests that multi-metal exposure, especially Cd, Fe, Zn, copper and Pb, is linked to diabetes mellitus, and the interactive effects of multiple metals require further exploration.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 81%

Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Zhang

Yin

Zhu

et al. 2022

J of Diabetes Invest

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“…Lipidomic analysis was also performed by Personal Biotechnology Co., Ltd (Shanghai, China) using the method reported previously. , Shortly, the entire sample analysis was performed at 8 °C in the autosampler. Then, LipidSearch software (Version 4.1, Thermo Scientific , California, USA) was used to process the raw data for lipid annotation to gain the results of mass to change ratio, retention time, intensity, and so on.…”

Section: Materials and Methodsmentioning

confidence: 99%

Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway

Zhang

Yao

et al. 2021

J. Agric. Food Chem.

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The present study revealed the phylactic effects of l-theanine on a DSS-induced colitis mice model. The results showed that 3% DSS treatment significantly induced intestinal damage as reflected by DAI, histopathological feature, and colon length, while l-theanine pretreatment markedly prevented these trends to exert protective effects. Meanwhile, l-theanine pretreatment decreased the levels of TNF-α, IL-1β, IL-6, iNOS, and COX2 on DSS-induced colitis. Notably, DSS inhibited the proliferation and promoted the apoptosis of intestinal epithelial cells, thereby damaging the integrity of the intestinal epithelial barrier, whereas l-theanine also played a protective role by attenuating these deteriorated effects. It was also observed that l-theanine treatment downregulated the levels of p-p65, p65, p-p53, p53, and p-AKT protein expression in acute DSS-induced colitis, which showed the protective function of l-theanine, mainly via the NF-κB signaling pathway. Furthermore, the results of lipid analysis and transcriptome analysis show that l-theanine reversed transcriptional profiles and lipid profiles of colitis models, mainly via the inflammatory reactivity-related pathway. Interestingly, the correlation analysis between transcriptional profiles and lipid profiles showed that inflammatory response-related genes were almost significantly correlated with differential lipid metabolites. In summary, l-theanine plays a protective role in DSS-induced colitis via downregulating the NF-κB signaling pathway and regulating lipid metabolism disorders.

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“…2 The presence of Cd has been associated with cancer, diabetes, intestinal disease, cardiovascular disease and neurologic disease. 3,4 The gut is about the first organ to be damaged by Cd exposure from contaminated food and water. Cd directly affects the complex intestinal ecosystem and its physiological structure of the whole transport process.…”

Section: Introductionmentioning

confidence: 99%

Rice hull insoluble dietary fiber alleviated experimental colitis induced by low dose of dextran sulfate sodium in cadmium-exposed mice

et al. 2022

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Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism

Cited by 87 publications

References 57 publications

Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway

Rice hull insoluble dietary fiber alleviated experimental colitis induced by low dose of dextran sulfate sodium in cadmium-exposed mice

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