Rice hull insoluble dietary fiber alleviated experimental colitis induced by low dose of dextran sulfate sodium in cadmium-exposed mice

Abstract

Cadmium (Cd) can invade gastrointestinal tract and induce the occurrence of gastrointestinal diseases. Rice hull insoluble dietary fiber (RHF) could be used as a novel dietary supplement strategy against Cd exacerbated colitis.

Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria

“…68,69 In contrast, Group 2 bacterial taxa Erysipelatoclostridium and E. fissicatena persistently increase after colitis development, as reported elsewhere. [70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] While the mechanisms behind this increase are unclear, our data align with the literature while also contributing a finer time scale regarding their changes in abundance during colitis.…”

“…Despite a limited number of studies noting the contrary 99,[114][115][116] , these results are in accordance with the behaviour of Erysipelatoclostridium reported in prior studies during intestinal disturbance. Indeed, this genus and one of its species, namely Clostridium ramosum (also known as E. ramosum or Thomasclavelia ramosum), [117][118][119] have been associated with intestinal inflammation or injury in humans, 46,48,73,[120][121][122][123][124][125][126][127] increasing in abundance in mouse models of colitis [71][72][73][74][75][76][77][78][79][80][81][82] and infection 128 , and being positively correlated with fecal water content (i.e., diarrhea), a common colitis symptom 2,[22][23][24]129,130 . The high replication activity of Erysipelatoclostridium we report demonstrates that it is a particularly active taxon during colitis, resulting in a possibly outsized impact on the microbial environment and the host.…”

“…with intestinal inflammation or injury in humans, 46,48,73,[120][121][122][123][124][125][126][127] increasing in abundance in mouse models of colitis [71][72][73][74][75][76][77][78][79][80][81][82] and infection 128 , and being positively correlated with fecal water content (i.e., diarrhea), a common colitis symptom 2,[22][23][24]129,130 . The high replication activity of Erysipelatoclostridium we report demonstrates that it is a particularly active taxon during colitis, resulting in a possibly outsized impact on the microbial environment and the host.…”

Let food be your medicine – dietary fiber

“…Food & Function NF-κB pathway. 125 The addition of licorice polysaccharides to the diet of mice with LPS-induced colitis could alleviate colonic inflammation by inhibiting LPS-induced up-regulation of TNF-α, IL-1β, and IL-6 by increasing the abundance of beneficial bacteria, such as Lactobacillus, Bacteroides, and Akkermansia, in the intestinal tract. 126 Importantly, attenuating the inflammatory response and immune cell infiltration of the mucosal immune system during active IBD is a potential target for immunotherapy.…”

“…The effects of RHF alleviated colonic inflammation mainly by increasing the abundance of the probiotic bacteria Eubacterium and Faecalibaculum in the intestine to produce more SCFAs and by inhibiting the transcriptional regulation of inflammatory factors mediated by the NF-κB pathway. 125 The addition of licorice polysaccharides to the diet of mice with LPS-induced colitis could alleviate colonic inflammation by inhibiting LPS-induced up-regulation of TNF-α, IL-1β, and IL-6 by increasing the abundance of beneficial bacteria, such as Lactobacillus , Bacteroides , and Akkermansia , in the intestinal tract. 126 Importantly, attenuating the inflammatory response and immune cell infiltration of the mucosal immune system during active IBD is a potential target for immunotherapy.…”