C-reactive protein, glucose and iron concentrations are significantly altered in dogs undergoing open ovariohysterectomy or ovariectomy

Moldal, Elena Regine; Kjelgaard‐Hansen, Mads; Peeters, Marijke E.; Nødtvedt, Ane; Kirpensteijn, Jolle

doi:10.1186/s13028-018-0384-6

Cited by 13 publications

(16 citation statements)

References 52 publications

(78 reference statements)

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“…All dogs displayed a significant increase in CRP 18 h after surgery. These results are consistent with previous studies reporting an increase in CRP within the first 24 h after OHE with a subsequent reduction in the absence of ongoing trauma (32)(33)(34)(35)(36). HBOT has been shown, previously, to reduce CRP concentration in people with traumatic brain injury treated with 4 hyperbaric oxygen treatments at 3-day intervals (1 h on 100% oxygen at 2.0 ATA) (5), and in children with autism after 40 hyperbaric oxygen treatments at 1-to 2-day intervals (45 min on 100% oxygen at 1.3 and 1.5 ATA) (37).…”

Section: Discussionsupporting

confidence: 93%

Effects of Ovariohysterectomy and Hyperbaric Oxygen Therapy on Systemic Inflammation and Oxidation in Dogs

et al. 2020

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Introduction: Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen in a specialized compression chamber leading to hyperoxia. This treatment modality is associated with anti-inflammatory, antioxidant, and healing properties in people and laboratory animals. However, there are relatively few reports that evaluate the effects of HBOT in companion animals. The goal of this study was to investigate the physiological effects of HBOT on surgically induced systemic inflammation and oxidation in dogs.Material and Methods: Twelve healthy female beagle dogs were spayed and randomized into control and HBOT groups (n = 6). Both groups received conventional post-ovariohysterectomy therapy, and the HBOT group received two hyperbaric treatments at 2.0 atmosphere of absolute pressure and 100% oxygen for 35 min, 6 and 18 h after surgery. Blood samples were collected 3 h prior to ovariohysterectomy, 6, 18, and 30 h after surgery, prior to HBOT when applicable. Inflammatory biomarkers, including C-reactive protein, circulating cytokines, and changes in iron homeostasis were evaluated at each time point to determine the effects of surgery and HBOT on inflammation. Similarly, serum total oxidant status and total antioxidant status were measured to assess the oxidative stress. Pain and incision scores were recorded and compared between groups.Results: Following ovariohysterectomy, all dogs had significantly increased serum concentrations of C-reactive protein, KC-like, IL-6, and increased unsaturated ironbinding capacity compared to their pre-surgical values (p < 0.02), while serum iron, total iron-binding capacity and transferrin saturation were significantly decreased after surgery (p < 0.02). There was no significant difference between the control group and the HBOT group for any of the variables. There were no overt adverse effects in the HBOT group. Conclusion:This is the first prospective randomized controlled study to investigate the effects of HBOT on surgically induced systemic inflammation in dogs. While elective ovariohysterectomy resulted in mild inflammation, the described HBOT protocol Gautier et al.Ovariohysterectomy and HBOT in Dogs portrayed no outward adverse effect and did not induce any detectable pro-inflammatory, anti-inflammatory, or antioxidant effects. Additional investigation is required to identify objective markers to quantify the response to HBOT and determine its role as an adjunctive therapy in dogs with more severe, complicated or chronic diseases.

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Section: Discussionsupporting

confidence: 93%

Effects of Ovariohysterectomy and Hyperbaric Oxygen Therapy on Systemic Inflammation and Oxidation in Dogs

et al. 2020

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“…High CRP indicates either acute phase response or local wound problems. Moldal et al (2018) reported that OHE and OVE induce a surgical stress response with postoperative increases in glucose concentration and CRP, but not signifcant diference between the OHE and OVE. Dabrowski et al (2009) mentioned that the difficulties in postoperative wound healing were induced by infection with Escherichia coli and Staphylococcus spp., leading to re-increased levels of CRP and SAA immediately after surgery and persistently higher levels throughout the experiment.…”

Section: Introductionmentioning

confidence: 94%

C-reactive Protein as a Quantitative Biomarker in Female Dogs Undergoing Laparoscopic and Open Elective Ovariectomy

Kumari

Guha

Tiwary

et al. 2021

IJAR

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Background: Injury or inflammation to the animal body resulted in the initiation of the acute-phase response (APR). Many plasma proteins increase in concentration in response to inflammatory stimuli, but C- reactive protein is considered as the most suitable markers due to their rapid and substantial increase in concentration and short half-lives. The CRP response varied according to the degree of surgical trauma on 3-standardized levels indicating CRP as an inflammatory activity indicator and monitoring markers. The aim of this study was to assess CRP concentrations in female dogs undergoing laparoscopic and open elective ovariectomy. Methods: The studies were conducted on twenty clinically healthy, adult, female dogs under elective spaying. Twenty healthy bitches were randomly assigned into four groups (A, B, C and D) consisting of five animals in each group. The studies were conducted in two phases (I and II).In phase I ovariectomy had been performed in animals of groups A and B with laparoscopy whereas, in phase II ovariectomy in animals of groups C and D were done by open laparotomy. Result: The pre-treatment CRP values did not show any significant change whereas post treatment values of group B were significantly lower as compared to groups D and C. On day 4th, group D values were significantly higher than groups C, B and A. Group C values were also significantly higher than group B. The highest value in group D might be due to more surgical manipulations and post-operative infection at surgical site in the animals under this group.

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“…Described techniques for bitch surgical sterilization are ovariectomy (OVE) and ovariohysterectomy (OVH), being both equally effective. OVE has potential advantages as smaller incisions, better viewing of the ovarian vessels and lower risk of surgical complications [26][27][28][29][30]. However, this technique should not be used if there is uterine disease or to prevent uterine neoplasm [26].…”

Section: Introductionmentioning

confidence: 99%

“…These inflammatory biomarkers have also been studied in conjunction with the leucogram to monitor the post-operative period in dogs [60,61], as well as after surgical trauma in other species such as cows [62,63]. Specific studies on APR after surgical neutering (OVE or OVH techniques) are described in both dogs and cats [11,16,28,58].…”

Section: Introductionmentioning

confidence: 99%

Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis

Romero

Cuervo

Peláez

et al. 2020

Animals

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Acute phase proteins (APP) are biomarkers of systemic inflammation, which allow monitoring the evolution of diseases, the response to treatments, and post-operative complications. Ovariectomy (OVE) is frequently performed in veterinary medicine and can be a useful model to evaluate surgical trauma and inflammation in the bitch. The objective was to investigate and compare the acute phase response (APR) after applying three different OVE techniques by measuring serum levels of C-reactive protein (CRP), haptoglobin (Hp), albumin (Alb), and paraoxonase-1 (PON-1). Forty-five intact bitches were included in the study, being randomly distributed into three groups: laparoscopic OVE (L), midline OVE (M), and flank OVE (F). Serum CRP, Hp, Alb, and PON-1 were measured before surgery, 1, 24, 72, and 168 h post-intervention. CRP levels increased significantly 24 h post-surgery in the M and F groups, but no significant variation was observed in the L group at any time of the study period. Hp was significantly higher in group L than in group F 72 h post-surgery. Alb and PON-1 showed no statistical difference among groups or among sampling periods. CRP response suggests that the use of laparoscopic procedures produce lower inflammation compared to open conventional approaches when performing OVE in the bitch.

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C-reactive protein, glucose and iron concentrations are significantly altered in dogs undergoing open ovariohysterectomy or ovariectomy

Cited by 13 publications

References 52 publications

Effects of Ovariohysterectomy and Hyperbaric Oxygen Therapy on Systemic Inflammation and Oxidation in Dogs

Effects of Ovariohysterectomy and Hyperbaric Oxygen Therapy on Systemic Inflammation and Oxidation in Dogs

C-reactive Protein as a Quantitative Biomarker in Female Dogs Undergoing Laparoscopic and Open Elective Ovariectomy

Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis

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