C-reactive protein detection based on ISFET structure with gate dielectric SiO2-CeO2

Kutova, Oksana Yuriivna; Dusheiko, Mykhailo; Klyui, N.I.; Skryshevsky, V. A.

doi:10.1016/j.mee.2019.110993

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…ISFETs for a variety of protein sensings, such as interleukin and C-reaction protein, which is highly relative to human health status, have also been successfully demonstrated recently. [145,146] However, as the signal changes modulated by the protein's interaction are relatively weak and can be largely interfered with by background noises, their practical applications are largely limited. Device structural innovation and materials engineering on the functionalized sensitive layers are critical to further enhance the sensing sensitivity, accuracy, and reproducibility, as well as lower the fabrication costs.…”

Section: Proteinmentioning

confidence: 99%

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Recent advances in ion‐sensitive field‐effect transistors for biosensing applications

Peng

Mao

et al. 2022

Electrochemical Science Adv

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Over the past decades, considerable development and improvement can be observed in the area of the ion‐sensitive field‐effect transistor (ISFET) for biosensing applications. The mature semiconductor industry provides a solid foundation for the commercialization of the ISFET‐based sensors and extensive research has been conducted to improve the performance of ISFET, with a special research focus on the materials, device structures, and readout topologies. In this review, the basic theories and mechanisms of ISFET are first introduced. Research on ISFET gate materials is reviewed, followed by a summary of typical gate structures and signal readout methods for the ISFET sensing system. After that, a variety of biosensing applications including ions, deoxyribonucleic acid, proteins, and microbes are presented. Finally, the prospects and challenges of the ISFET‐based biosensors are discussed.

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Section: Proteinmentioning

confidence: 99%

“…ISFETs for a variety of protein sensings, such as interleukin and C‐reaction protein, which is highly relative to human health status, have also been successfully demonstrated recently. [ 145,146 ]…”

Section: Biosensing Applicationsmentioning

confidence: 99%

Recent advances in ion‐sensitive field‐effect transistors for biosensing applications

Peng

Mao

et al. 2022

Electrochemical Science Adv

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“…Thus, the results which were obtained in this work make it possible to state that sensors with gate dielectric CeO 2 can be used for the manufacture of a wide range of biosensors, in particular, the sensor C-reactive protein [10].…”

Section: Resultsmentioning

confidence: 72%

Beta-Lactoglobulin Sensor Based on ISFET with CеO2 Gate Dielectric

Kutova

Tymofieiev

Dusheiko

et al. 2019

Mìkrosist. elektron. akust.

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In this article sensor with improved measurement technique for the detection of milk allergens was developed. β-lactoglobulin (BLG) protein was used as the biomarker for cow milk detection. The structure of the sensor with nanocrystalline cerium oxide is proposed with an advanced measurement method, which consists of using a micro-flow system to provide a constant volume of the substance to be tested for the dynamic analysis of the beta-lactoglobulin protein, the major milk allergen. The influence of illumination on the experiment and the degree of cleaning of the sensor surface between each measurement are analyzed. Because the existing ELISA method is too long (1.5 hours), and the proposed method allows to identify the presence of beta-lactoglobulin in a few minutes.

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“…Ceria hollow NPs have also been proposed for sensing useful biomolecules for health monitoring. These not only included sensors for glucose [ 21 , 146 , 158 , 159 , 160 ], whose levels require careful monitoring for diabetic patients, but also the C-reactive protein [ 161 ], which is a biomarker for acute inflammation. Other sensing targets were the amyloid beta protein [ 162 , 163 ] and dopamine [ 164 , 165 ], both of which are relevant to neurodegenerative processes, and, in particular, Alzheimer’s and Parkinson’s disease, respectively.…”

Section: (Bio)applicationsmentioning

confidence: 99%

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

et al. 2021

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Ceria (CeO2) nanostructures are well-known in catalysis for energy and environmental preservation and remediation. Recently, they have also been gaining momentum for biological applications in virtue of their unique redox properties that make them antioxidant or pro-oxidant, depending on the experimental conditions and ceria nanomorphology. In particular, interest has grown in the use of biotemplates to exert control over ceria morphology and reactivity. However, only a handful of reports exist on the use of specific biomolecules to template ceria nucleation and growth into defined nanostructures. This review focusses on the latest advancements in the area of biomolecular templates for ceria nanostructures and existing opportunities for their (bio)applications.

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C-reactive protein detection based on ISFET structure with gate dielectric SiO2-CeO2

Cited by 13 publications

References 24 publications

Recent advances in ion‐sensitive field‐effect transistors for biosensing applications

Recent advances in ion‐sensitive field‐effect transistors for biosensing applications

Beta-Lactoglobulin Sensor Based on ISFET with CеO2 Gate Dielectric

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

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