C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese

CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese

“…CRP gene polymorphism clearly influences serum CRP levels (12)(13)(14), and elevated CRP levels have been associated with unfavorable outcomes after acute IS (3)(4)(5)(6). However, few studies have examined whether CRP genetic variation can predict the prognosis of patients with IS.…”

“…CRP SNPs were selected on the basis of published data on the Han Chinese population (13). Genotyping for the CRP SNPs rs1130864 and rs1800947 was performed using the ligation detection reaction method (19) with technical support from Shanghai Biowing Applied Biotechnology (www.biowing.com.cn).…”

“…Accumulating evidence has demonstrated that single nucleotide polymorphisms (SNPs) in the CRP gene may strongly affect CRP levels under normal conditions and following IS (12)(13)(14). For example, certain SNPs have been shown to influence serum CRP levels in different ethnic groups (15), with a recent study (13) reporting the association of SNPs rs1130864 and rs1800947 with baseline levels of serum CRP in Han Chinese. Therefore, genotyping CRP SNPs may help assess the impact of permanently high CRP levels on patient outcome after stroke, independently of other risk factors.…”

Hypertension and C-reactive protein

“…Early studies that used this methodology, termed Mendelian randomization, showed conflicting results, 12,13 but more recent larger studies have been consistent in showing no association between CRP SNPs and cardiovascular disease. 14,15 In this issue of the Journal, Kong et al 16 study the association of CRP SNPs, circulating CRP levels and hypertension in a population of Han Chinese descent. The population included a random sample of 2000 subjects (909 with hypertension at study entry) recruited in 2008 when a total of eight CRP SNPs (rs1205, rs1800947, rs3093059, rs2211321, rs2027469, rs12031749, rs1130864 and rs2246469) were genotyped, circulating CRP levels measured in plasma samples, blood pressure measured on three occasions and hypertension status determined.…”

“…It is important to point out, however, that the conclusions drawn from these genetic studies are limited by the phenotype that is examined. In the study by Kong et al 16 the phenotype is development of hypertension in participants who are normotensive at the study entry. As previously pointed out, the cutoff for the diagnosis of hypertension is artificial and therefore the lack of association with the development of hypertension does not exclude the possibility that CRP is directly involved in the disease process.…”