“…Early studies that used this methodology, termed Mendelian randomization, showed conflicting results, 12,13 but more recent larger studies have been consistent in showing no association between CRP SNPs and cardiovascular disease. 14,15 In this issue of the Journal, Kong et al 16 study the association of CRP SNPs, circulating CRP levels and hypertension in a population of Han Chinese descent. The population included a random sample of 2000 subjects (909 with hypertension at study entry) recruited in 2008 when a total of eight CRP SNPs (rs1205, rs1800947, rs3093059, rs2211321, rs2027469, rs12031749, rs1130864 and rs2246469) were genotyped, circulating CRP levels measured in plasma samples, blood pressure measured on three occasions and hypertension status determined.…”