Hypertension and C-reactive protein

Hage, Fadi G.

doi:10.1038/hr.2012.126

Cited by 2 publications

(1 citation statement)

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“…Studies have demonstrated CRP to be associated with obesity, increased waist circumference and systolic BP; these parameters can be used for identification and intervention in children and adolescents with high risk of atherosclerosis 9 . An expanding body of evidence indicates that inflammation has a major role to play in the development of high BP; elevated levels of CRP have been shown to be associated with the incidence of hypertension in middle‐aged adults 37,38 . In the present study, most of those who had stage 1 hypertension were in the high‐risk CRP category (CRP > 3 mg/L), and conversely, none of those with high‐risk CRP were with normal BP.…”

Section: Discussionmentioning

confidence: 45%

Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study

Soman

Chandy

Alkhathami

et al. 2023

Health Science Reports

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Background and Aims Retro walking has been shown to acquire a greater metabolic cost, placing a higher cardiopulmonary demand on the body, when compared with forward walking at a similar speed. The aim of this study was to compare the effect of retro walking with that of forward walking on C‐reactive protein (CRP) levels, body mass index (BMI) and blood pressure (BP) and to understand the influence of independent factors namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and BMI on CRP in untrained overweight and obese young adults. Methods This was a randomised controlled trial whereby 106 participants underwent either retro walking ( n = 53) or forward walking ( n = 53) treadmill training four times a week for 12 weeks before and after which CRP, BMI, and BP levels were measured. Comparison of the measured values before and after intervention and between the groups was done and influence of BMI and BP on CRP levels was determined. Results Both groups recorded a significant decrease ( p < 0.001) in CRP, BMI, and BP levels postintervention. The participants who underwent retro walking training showed a significantly ( p < 0.001) higher decrease in all the outcomes as compared with the forward walking group. C‐reactive protein levels were seen to be influenced by BMI and DBP. Conclusion Retro‐walking training leads to greater decrease in CRP, BMI, and BP when compared with forward walking, and CRP levels are influenced by BMI and DBP. Retro walking treadmill training can be used preferentially to bring about reduction in cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 45%

Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study

Soman

Chandy

Alkhathami

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

show abstract

C-reactive protein and Hypertension

2013

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C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in individuals who are at intermediate risk. This paper reviews the role of CRP in hypertension. In hypertensive individuals, CRP levels associate with vascular stiffness, atherosclerosis and the development of end-organ damage and cardiovascular events. Data suggest that some anti-hypertensive medications may lower CRP levels in a manner independent of their effect on blood pressure. In individuals who are normotensive at baseline, CRP levels have been shown in multiple cohorts to foretell the development of hypertension on follow-up. Whether genetic variability that influences circulating levels of CRP independent of environmental and behavioral factors can also be used in a similar manner to predict the change in blood pressure and development of hypertension is controversial. In addition to its role as a biomarker, experimental studies have unraveled an active direct participation of CRP in the development of endothelial dysfunction, vascular stiffness and elevated blood pressure. CRP has also been implicated as a mediator of vascular remodeling in response to injury and cardiac remodeling in response to pressure overload. Emerging data may reveal novel vascular inflammatory pathways and identify new targets for treatment of vascular pathology.

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Hypertension and C-reactive protein

Cited by 2 publications

References 31 publications

Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study

Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study

C-reactive protein and Hypertension

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