CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese

Guo, Jian; Yu, Lan; Chen, N.; Zhou, Muke

doi:10.1111/ane.12180

Cited by 10 publications

(6 citation statements)

References 25 publications

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“…Many investigators have demonstrated that a high CRP level after ischemic stroke is a predictive factor of poor outcome [ 7 , 24 , 25 , 26 , 27 , 36 ]. Therefore, testing the CRP level would not only identify patients being at high risk, but would also provide an opportunity for intervention.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, an increased level of CRP remarkably associated with the functional prognosis of AIS was observed in multiple studies [ 4 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Nevertheless, most of the previous studies investigating the prognosis of patients with acute ischemic stroke were mainly focused on new stroke attack and mortality [ 21 , 23 , 24 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between C-Reactive Protein Level and Discharge Outcome in Patients with Acute Ischemic Stroke

Geng

Xin-wang

Fu³

et al. 2016

IJERPH

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Previous studies showed that C-reactive protein (CRP), an inflammatory marker, was associated with stroke severity and long-term outcome. However, the relationship between the acute-phase CRP level and discharge outcome has received little attention. We prospectively studied 301 patients with acute ischemic stroke (over a period of two weeks) from two hospital stroke wards and one rehabilitation department in Henan, China. Patients’ demographic and clinical data were collected and evaluated at admission. Poor discharge outcome was assessed in patients at discharge using the Modified Rankin Scale (MRS > 2). Multivariate logistic regression analysis was performed to determine the risk factors of poor discharge outcome after adjusting for potential confounders. Poor discharge outcome was observed in 78 patients (25.9%). Univariate analyses showed that factors significantly influencing poor discharge outcome were age, residence, recurrent acute ischemic stroke, coronary heart disease, the National Institutes of Health Stroke Scale (NIHSS) score at admission, non-lacunar stroke, time from onset of stroke to admission, CRP, TBIL (total bilirubin), direct bilirubin (DBIL), ALB (albumin), FIB (fibrinogen) and D-dimer (p < 0.05). After adjusting for age, residence, recurrent ischemic stroke, coronary heart disease, NIHSS score at admission, lacunar stroke, time from onset of stroke to admission, CRP, TBIL, DBIL, ALB, FIB and D-dimer, multivariate logistic regression analyses revealed that poor outcome at discharge was associated with recurrent acute ischemic stroke (OR, 2.115; 95% CI, 1.094–4.087), non-lacunar stroke (OR, 2.943; 95% CI, 1.436–6.032), DBIL (OR, 1.795; 95% CI, 1.311–2.458), and CRP (OR, 4.890; 95% CI, 3.063–7.808). In conclusion, the CRP level measured at admission was found to be an independent predictor of poor outcome at discharge. Recurrent acute ischemic stroke, non-lacunar stroke and DBIL were also significantly associated with discharge outcome in acute ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Relationship between C-Reactive Protein Level and Discharge Outcome in Patients with Acute Ischemic Stroke

Geng

Xin-wang

Fu³

et al. 2016

IJERPH

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“…Serum CRP levels are affected by CRP gene polymorphism (9,42). A previous study found that the CRP gene SNP rs1130864 was an independent predictor of poor short-term prognosis in patients with first ischemic stroke (43). Third, the sampling time following stroke onset may have influenced our results.…”

Section: Discussionmentioning

confidence: 83%

Elevated high-sensitivity C-reactive protein levels predict poor outcomes among patients with acute cardioembolic stroke

Wang¹,

Song²,

Wang³

et al. 2021

Ann Palliat Med

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Cardioembolic stroke (CES) is a severe subtype of cerebral infarction, accounting for 20% of cerebral infarctions (1). This condition is characterized by high in-hospital mortality rates (27.3%) (2), neurological deficits at hospital discharge, and a high risk of stroke recurrence (26%) (3). However, the prognostic indicators for patients with CES remain unclear. Acute strokes may trigger an inflammatory response, leading to elevated C-reactive protein (CRP) levels ( 4), which may be associated with poor prognosis as they reflect inflammation or tissue damage (5). Therefore,

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“…Interestingly, six other loci associated with CRP levels in that study were involved in metabolic regulation of diabetes mellitus. It has been also showed that some CRP variants are associated with raised levels of serum CRP while others with decreased ones (Guo et al 2014 ; Kong et al 2012 ; Miller et al 2005 ; Ottaviani et al 2011 ; Russell et al 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Association between CRP genetic diversity and bipolar disorder comorbid complications

Boukouaci

Oliveira

Étain

et al. 2018

Int J Bipolar Disord

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BackgroundChronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute phase response molecule, C-reactive protein (CRP). While the genetic diversity of CRP was amply studied in various pathological settings, little is known in BD.Methods568 BD patients along with 163 healthy controls (HC) were genotyped for the following single-nucleotide polymorphisms (SNPs) on the CRP gene: intron rs1417938 (+ 29) T/A, 3′-UTR rs1130864 (+ 1444) G/A, and downstream rs1205 (+ 1846) (C/T). The statistical analysis was performed using Chi-square testing and consisted of comparisons of allele/genotype frequencies between patients and controls and within patient sub-groups according to BD clinical phenotypes and the presence of thyroid disorders.ResultsWe found that the frequencies of the studied SNPs were similar in BD and HC groups. However, the CRP rs1130864 A allele carrier state was significantly more frequent: (i) in BD patients with thyroid disorders than in those without (pc = 0.046), especially among females (pc = 0.01) and independently of lithium treatment, (ii) in BD patients with rapid cycling than in those without (pc = 0.004).ConclusionsOverall, our findings suggest the possibility that CRP genetic diversity may contribute to the development of auto-immune comorbid disorders and rapid cycling, both proxy of BD severity. Such findings, if replicated, may allow to predict complex clinical presentations of the disease, a possible step towards precision medicine in psychiatry.

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CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese

Abstract: Our study indicates that SNP rs1130864 in the CRP gene is an independent predictor of 3-month functional outcome in patients with first-onset IS in a Han Chinese population. Further studies in different ethnic groups are needed to validate our findings.

Cited by 10 publications

References 25 publications

The Relationship between C-Reactive Protein Level and Discharge Outcome in Patients with Acute Ischemic Stroke

The Relationship between C-Reactive Protein Level and Discharge Outcome in Patients with Acute Ischemic Stroke

Elevated high-sensitivity C-reactive protein levels predict poor outcomes among patients with acute cardioembolic stroke

Association between CRP genetic diversity and bipolar disorder comorbid complications

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