C-Reactive Protein and Body Mass Index in Patients with Type -2 Diabetes Mellitus and Diabetic Retinopathy

Mocanu, Valeria; Timar, Romulus; Horhat, Raluca; Bucur, Adina; Şerban, Viorel

doi:10.2478/rjdnmd-2013-0016

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…5 Previous studies have shown that stress with or without type 2 diabetes is associated with increased cortisol levels and lower testosterone. 6,7,8,9 CRHR1, CYP17A1, and FKBP5 are defined as stress system genes mainly expressed in the following tissues: the pituitary gland, adrenal gland, and skeletal muscle. The gene CYP17 is responsible for making an enzyme that converts cholesterol into cortisol.…”

Section: Stress Induced Cortisol Release Depresses the Secretion Of T...mentioning

confidence: 99%

Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus

Khan

Jannat

Shaukat

et al. 2023

Clin Med Insights Endocrinol Diabetes

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Background: Both hormonal and genetic data reveal that the stress hormone cortisol and its regulating genes may affect the level of testosterone in humans. It is uncertain whether type 2 diabetes mellitus would manifest similarly. Furthermore, a genetic strategy to screen out the stress system genes that may contribute to testosterone decline in humans is less understood. Objectives: In this study, we aimed to elucidate the link between stress and testosterone levels, both hormonally and genetically. Method: This study comprised 37 individuals with type 2 diabetes mellitus and 50 healthy individuals. For the analysis of hormones and the targeted genes, we used the RIA system and bioinformatics expertise. Results: The patients had significantly elevated cortisol and lower testosterone readings, according to data from hormonal analyses. The bioinformatics approach reveals that SHBG was intracellularly suppressed by 2 defined stress system genes: FKB5 and CYP17. TCF4/TCF8, ATRX, and AR in skeletal muscle were inversely related to stress system genes. Furthermore, all testosterone regulated genes were positively linked with SHBG in the current study. A strong relationship between GNAS and PKA with CYP17 and FKBP5 reveals that the Gαs-cAMP/PKA signaling pathway may be one of the regulatory pathways through which the suppression of testosterone system genes happens. In conclusion, this study demonstrated that beyond stress, the key stress system genes might affect cortisol levels, which in turn affect testosterone figures via the Gαs-cAMP/PKA signaling pathway.

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Section: Stress Induced Cortisol Release Depresses the Secretion Of T...mentioning

confidence: 99%

Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus

Khan

Jannat

Shaukat

et al. 2023

Clin Med Insights Endocrinol Diabetes

View full text Add to dashboard Cite

show abstract

Correlation of C-reactive protein and glycosylated hemoglobin on severity of diabetic macular edema

Gopinath¹,

Kakkanatt²,

Bisto³

et al. 2019

Kerala J Ophthalmol

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C-Reactive Protein and Body Mass Index in Patients with Type -2 Diabetes Mellitus and Diabetic Retinopathy

Abstract: Background and aims: C-reactive protein (CRP) is an inflammatory biomarker that may be associated with diabetic retinopathy (DR). The body mass index (BMI) is

Cited by 2 publications

References 12 publications

Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus

Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus

Correlation of C-reactive protein and glycosylated hemoglobin on severity of diabetic macular edema

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