Correlation of C-reactive protein and glycosylated hemoglobin on severity of diabetic macular edema

Gopinath, Geethu; Kakkanatt, Anthrayos C V.; Bisto, AA; Mathai, Monsy T

doi:10.4103/kjo.kjo_38_19

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Our results can be explained by the nation that diabetes is closely related to inflammation. Higher platelet counts may reflect underlying inflammation as several inflammatory mediators stimulate megakaryocytic proliferation [23]. Our study stated that micro-vascular and macro-vascular complications of diabetes had significantly higher P/L ratio.…”

Section: Discussionmentioning

confidence: 56%

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Neutrophil-Lymphocyte and Platelet-Lymphocyte ratios as a marker for diabetes control and complications.

Elsayed

Araby

2021

Benha Medical Journal

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Introduction: Hematological changes affecting the red blood cells, white blood cells, platelet function, and the coagulation factors were associated with diabetes mellitus (DM). The neutrophil-tolymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications. Patients and Methods: A retrospective, cross sectional study of data from 200 patients with type 2 DM who attended the internal medicine clinic in Benha University Hospital. Clinical data were collected, including; age, sex, duration of DM, body mass index (BMI), micro-vascular and macrovascular complications of DM. Laboratory data were collected in the form of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG),complete blood count with calculation of the N/L, and P/L ratios. The selected patients were divided into two groups; group I (good glycemic control, HbA1c ≤ 7 %) and group II (bad glycemic control, HbA1c ˃7).Results: Age was statistically insignificant between the two groups (p value of 0.341).HbA1c, BMI, and FBG were significantly higher in group II. A significant higher total leucocyte, neutrophil, and platelet counts in group II were noticed (p = 0.000). There were a significant higher N/L and P/L ratios in uncontrolled diabetics. Linear regression analysis revealed that age, FBG, neutrophil count, P/L and N/L ratios were significant independent parameters associated with HbA1c. Conclusion: The present study proposed that N/L& P/L ratios may be independently associated with poor blood glucose regulation in patients with type 2 DM. Furthermore, diabetic complications were associated with higher N/L & P/L ratios.

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Section: Discussionmentioning

confidence: 56%

“…Beside this, one study demonstrated that patients with positive CRP were found to have elevated HbA1c values [23]. As previously known, elevated CRP levels, an inflammatory biomarker, is a predictor of development of type 2 diabetes and other metabolic syndromes [24].…”

Section: Discussionmentioning

confidence: 86%

Neutrophil-Lymphocyte and Platelet-Lymphocyte ratios as a marker for diabetes control and complications.

Elsayed

Araby

2021

Benha Medical Journal

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“…Duration of disease, insulin resistance, and genetic factors are unalterable components of metabolic control, while improved glycemic control and blood pressure with reduced HbA1c are proven to be efficacious in reducing the levels of hs-CRP resulting in slowing of DR progression. 18 This study showed a positive correlation of 13,19 Previous research suggests a significant correlation of hs-CRP with metabolic syndrome; however, it is unclear whether controlled metabolic components will reduce hs-CRP levels. 20,21 Albuminuria is another sensitive marker of severity of DR.…”

Section: Discussionmentioning

confidence: 63%

“…12 Findings from this study are in accordance with an Indian study conducted by Gopinath et al, who demonstrated the co-relation of inflammatory process and metabolic control in the pathogenesis of DR and diabetic macular edema as indicated by CRP and HbA1c. 13 A similar study was conducted by Peng et al, in Chinese patients with T2DM (N=1018) and it revealed that not only CRP but also its genetic variants are associated with DR. The mean age of patients with and without DR was 62.48 and 67.37 years, BMI of 24 kg/m 2 and duration of diabetes >10 years.…”

Section: Discussionmentioning

confidence: 63%

Serum high sensitivity C reactive protein levels in patients with diabetic retinopathy: a cross sectional study

Chaudhari

2020

Int J Adv Med

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Background: Diabetic retinopathy (DR) is one of the major visual morbidities associated with diabetes. This study determined the levels of serum high-sensitivity C-reactive protein (hs-CRP) in patients with DR and to correlate the estimated levels of serum hs-CRP with the severity of DR and other coexisting factors.Methods: This was a cross-sectional study conducted between March 2009 and August 2010 and included patients with type 2 diabetes mellitus (T2DM) with or without DR. A detailed fundus evaluation was performed using direct and indirect ophthalmoscopy. The retinopathies were observed and documented in accordance with the Kanski's system of classification as background DR (BDR), pre-proliferative DR (PPDR), and proliferative DR (PDR). Laboratory investigations determined the levels of fasting blood glucose (FBG), postprandial blood glucose (PPBG), glycosylated hemoglobin, urine albumin excretion, and serum hs-CRP levels.Results: In total, 80 patients with T2DM were included (DR group, n=40 [BDR, n=22; PDR, n=11; PPDR, n=7]; control group, n=40). Highest serum hs-CRP levels were found in PDR group (6.68 mg/L), followed by PPDR and BDR group (3.2 mg/L and 1.56 mg/L, respectively). The PDR group showed the longest duration of diabetes (16 years), highest FBG (221.8 mg/dL) and HbA1c (6.68 mg/L). The incidence of albuminuria and maculopathy was higher in PDR group (72.7% and 54.54%, respectively). A significant association of hs-CRP levels with DR in patients with T2DM was observed. A significantly (<0.005) positive correlation of hs-CRP was also observed with age, duration of disease, FBG, PPBG, and HbA1c.Conclusions: Patients with severe grades of retinopathy had significantly higher hs-CRP levels than patients with the milder grades.

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Correlation of C-reactive protein and glycosylated hemoglobin on severity of diabetic macular edema

Cited by 2 publications

References 14 publications

Neutrophil-Lymphocyte and Platelet-Lymphocyte ratios as a marker for diabetes control and complications.

Neutrophil-Lymphocyte and Platelet-Lymphocyte ratios as a marker for diabetes control and complications.

Serum high sensitivity C reactive protein levels in patients with diabetic retinopathy: a cross sectional study

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