c-Fos expression in supramammillary and medial mammillary nuclei following spatial reference and working memory tasks

Similarities and differences between the brain networks underlying allocentric and egocentric spatial learning in rat revealed by cytochrome oxidase histochemistry

“…Specifically, evidence was found of higher CO activity in SUM and MMN in spatial learning associated both with allocentric and egocentric strategies, compared to the control group. Previous studies of our laboratory using lesion approach, c-fos expression and CO activity with different procedures have revealed the behavioural role of the mammillary bodies in spatial alternation, spatial working memory and spatial reference memory (Santı´n et al, 1999(Santı´n et al, , 2003Aranda et al, 2008;Begega et al, 2010;Conejo et al, 2010).…”

“…With regard to the SUM, various learning conditions such as the radial maze, the Morris water maze and open field induce c-fos in it (Vann et al, 2000;Santı´n et al, 2003;Ito et al, 2009). Moreover, reversible inactivation of the SUM with lidocaine impaired consolidation of the reference memory version of the Morris water maze (Shahidi et al, 2004).…”

Neurotoxic lesions of the thalamic reuniens or mediodorsal nucleus in rats affect non-mnemonic aspects of watermaze learning

“…Based on changes in c-fos activity, Vann et al (2000) suggested that RE plays a role in working memory. However, c-fos imaging yields complex and sometimes controversial results (e.g., Aggleton et al 2000;Bertaina-Anglade et al 2000;Jenkins et al 2003;Santin et al 2003), while the precise role of c-fos in memory formation and the underlying mechanisms remain unknown (Herrera and Robertson 1996;Zhang et al 2002). Therefore, we used a conventional (reference memory) watermaze task, known to be sensitive to dysfunction of both the hippocampal and prefrontal systems, with each system mediating different aspects of watermaze learning.…”

The recognition of a novel-object in a novel context leads to hippocampal and parahippocampal c-Fos involvement

“…Studying c-Fos can provide information about the neuronal plasticity required for memory processes [21]. The expression of c-Fos protein is induced after learning, and it is indicative of a change in neuronal activity [21][22][23]. This technique allows the simultaneous examination of the activity of populations of neurons in multiple brain regions [24].…”