Similarities and differences between the brain networks underlying allocentric and egocentric spatial learning in rat revealed by cytochrome oxidase histochemistry

Rubio, Sandra; Begega, Azucena; Méndez, Marta; Méndez-López, Magdalena; Árias, Jorge L.

doi:10.1016/j.neuroscience.2012.07.066

Cited by 21 publications

(12 citation statements)

References 61 publications

(95 reference statements)

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“…These findings are consistent with the hypothesis that a corticostriatal system mediates stimulus-response habit formation, whereas a hippocampus-based system contributes to cognitive-spatial impairment [42]. However, Rubio et al [43] support a possible functional interaction between the two memory systems and their structural convergence may facilitate functional cooperation in behaviours guided by more than one strategy. Moreover, there is a well-known projection from the hippocampus to the ventral striatum, which is capable of modulating its firing [44].…”

Section: Discussionsupporting

confidence: 88%

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Arias

Méndez

Gómez-Lázaro

et al. 2015

Physiology & Behavior

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Section: Discussionsupporting

confidence: 88%

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Arias

Méndez

Gómez-Lázaro

et al. 2015

Physiology & Behavior

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“…The total deletion of Gpr88 in mice affects several forms of learning, which involve both striatal and hippocampal function (see References and Table ). In a first study, Gpr88 Cre/Cre mice showed normal turned‐based egocentric learning involving the striatum but cue‐based (allocentric) learning involving the hippocampus was delayed . In a further study using different testing paradigms, we reported facilitated hippocampal‐dependent behaviors in Gpr88 −/− mice, based on less repetitive arm re‐entries in the Y‐maze, higher preference for the displaced object in the novel object recognition test, and a faster acquisition and behavioral shift in the dual solution task using a cross‐maze, all requiring hippocampal integrity .…”

Section: Discussionmentioning

confidence: 81%

Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping

Maroteaux

Arefin

Harsan

et al. 2018

Genes Brain and Behavior

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Mouse models are widely used to understand genetic bases of behavior. Traditional testing typically requires multiple experimental settings, captures only snapshots of behavior and involves human intervention. The recent development of automated home cage monitoring offers an alternative method to study mouse behavior in their familiar and social environment, and over weeks. Here, we used the IntelliCage system to test this approach for mouse phenotyping, and studied mice lacking Gpr88 that have been extensively studied using standard testing. We monitored mouse behavior over 22 days in 4 different phases. In the free adaptation phase, Gpr88 mice showed delayed habituation to the home cage, and increased frequency of same corner returns behavior in their alternation pattern. In the following nose-poke adaptation phase, non-habituation continued, however, mutant mice acquired nose-poke conditioning similar to controls. In the place learning and reversal phase, Gpr88 mice developed preference for the water/sucrose corner with some delay, but did not differ from controls for reversal. Finally, in a fixed schedule-drinking phase, control animals showed higher activity during the hour preceding water accessibility, and reduced activity after access to water was terminated. Mutant mice did not show this behavior, showing lack of anticipatory behavior. Our data therefore confirm hyperactivity, non-habituation and altered exploratory behaviors that were reported previously. Learning deficits described in other settings were barely detectable, and a novel phenotype was discovered. Home cage monitoring therefore extends previous findings and shows yet another facet of GPR88 function that deserves further investigation.

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“…Similarly, systemic estradiol enhances place learning but impairs response learning for food reward, results apparently reflecting independent actions of direct application of estradiol into the hippocampus or striatum (Korol, 2004; Zurkovsky et al, 2007, 2011; Korol and Pisani, 2015; Pleil et al, 2011). Differential release of neurotransmitters, activation of transcription factors, and other biological factors in the hippocampus and striatum during and after training show correlations between these measures and the brain area used for learning and memory across tasks (Pych et al, 2005; Gold, 2004; Colombo, 2004; McIntyre et al, 2003; Chang and Gold, 2003a,b; Rubio et al, 2012; Mizumori et al, 2004; Mizumori and Jo, 2013). These correlational studies testing multiple memory systems were also mainly performed using training to find food rewards.…”

Section: Discussionmentioning

confidence: 98%

“…Several neurochemical and neurophysiological measures of activity in the hippocampus and striatum also exhibit task-specific differences (Pych et al, 2005; Gold, 2004; Mizumori and Jo, 2013; Colombo, 2004; McIntyre et al, 2003; Chang and Gold, 2003b; Pleil et al, 2011; Rubio et al, 2012). In particular, contrasting the response in the hippocampus, extracellular glucose in the striatum does not decline, and may actually rise, during working memory testing (McNay et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Training-induced elevations in extracellular lactate in hippocampus and striatum: Dissociations by cognitive strategy and type of reward

Newman

Scavuzzo

Gold

et al. 2017

Neurobiology of Learning and Memory

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Recent evidence suggests that astrocytes convert glucose to lactate, which is released from the astrocytes and supports learning and memory. This report takes a multiple memory perspective to test the role of astrocytes in cognition using real-time lactate measurements during learning and memory. Extracellular lactate levels in the hippocampus or striatum were determined with lactate biosensors while rats were learning place (hippocampus-sensitive) or response (striatum-sensitive) versions of T-mazes. In the first experiment, rats were trained on the place and response tasks to locate a food reward. Extracellular lactate levels in the hippocampus increased beyond those of feeding controls during place training but not during response training. However, striatal lactate levels did not increase beyond those of controls when rats were trained on either the place or the response version of the maze. Because food ingestion itself increased blood glucose and brain lactate levels, the contribution of feeding may have confounded the brain lactate measures. Therefore, we conducted a second similar experiment using water as the reward. A very different pattern of lactate responses to training emerged when water was used as the task reward. First, provision of water itself did not result in large increases in either brain or blood lactate levels. Moreover, extracellular lactate levels increased in the striatum during response but not place learning, whereas extracellular lactate levels in the hippocampus did not differ across tasks. The findings from the two experiments suggest that the relative engagement of the hippocampus and striatum dissociates not only by task but also by reward type. The divergent lactate responses of the hippocampus and striatum in place and response tasks under different reward conditions may reflect ethological constraints tied to foraging for food and water.

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Similarities and differences between the brain networks underlying allocentric and egocentric spatial learning in rat revealed by cytochrome oxidase histochemistry

Cited by 21 publications

References 61 publications

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping

Training-induced elevations in extracellular lactate in hippocampus and striatum: Dissociations by cognitive strategy and type of reward

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