Bullous amyloidosis

Ruzicka, Thomas; SCHMOECKEL, C.; RING, J.; Linke, Reinhold P.; Braun‐Falco, Otto

doi:10.1111/j.1365-2133.1985.tb02047.x

Cited by 32 publications

(9 citation statements)

References 16 publications

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“…Among them, alopecia, 109-111 cutis laxa, [112][113][114][115] or bullae. [116][117][118][119][120][121][122][123][124] Blisters are also frequent due to cleavage developing within the amyloid deposits and many times are hemorrhagic and occur on the tongue or bucal mucosa (Fig. 7).…”

Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.

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Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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“…Flow cytometry of an aspirated bone marrow specimen yielded a monoclonal population of CD138 positive, IgG κ plasma myeloma cells. Conventional cytogenetic examination showed a normal female karyotype of 46 XX; however, FISH was positive for monosomy of chromosome 13 (loss of both RB1 and LAMP1) in 10.3% of cells, and t [6,7], indicating overexpression of BCL1, and cyclin D1 (CCND1/IGH) rearrangement in 5.8% of the cells. Bone survey revealed multiple lytic bone lesions, including the left greater femoral trochanter, right humeral head, and T12 vertebral bodies.…”

Section: Case Reportmentioning

confidence: 99%

Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature

Agheli

Becker

et al. 2012

Exp Hematol Oncol

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Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of bullous skin lesions is rare. Little is known about the mechanism of blister formation. These blisters are often hemorrhagic and typically occur in the oral mucosa. Only a few case reports have described skin involvement in systemic amyloidosis. The manifestation of bullous lesions on the breast in association with primary amyloidosis has not been previously reported. Therefore, we report a case of cutaneous hemorrhagic bullous of the breast secondary to primary systemic amyloidosis, which may be important for medical oncologists to be aware of this uncommon presentation of plasma cell dysrasias. Furthermore, this case only partially responded to the commonly used multiple myeloma-type regimen, the skin lesions responded completely to a five-drug combination chemotherapy regimen, utilizing immunomodulators, liposomal doxorubicin, cyclophosphamide, bortezomib, and dexamethasone, suggesting that a more aggressive modality of chemotherapy may be necessary to treat such cases.

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“…5,7 Occasionally, no splits are observed after amyloid deposition; amyloid bodies below lamina densa cause the disruption at the level of the lamida lucida. 8 Ochiai et al 9 observed keratinocyte protrusions penetrating the basal membrane and surrounding the amyloid below the lamina densa.…”

Section: Discussionmentioning

confidence: 98%