Bullins et bilharzioses en Corse

Doby, J. M.; Rault, B.; Deblock, S.; Chabaud, A. G.

doi:10.1051/parasite/1966414337

Cited by 15 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1966, Jean-Marie Doby, a French parasitologist, stated that Corsica met all the requirements for permanent transmission of urogenital schistosomiasis [6]. This became true nearly 50 years later when more than 120 cases of autochthonous schistosomiasis were diagnosed in France.…”

Section: Discussionmentioning

confidence: 98%

“…This suggests that the wide-scale screening of more than 37,000 people in France [6] did not identify all human carriers shedding Schistosoma eggs. If that is the case, it is possible that schistosomiasis could be spread to other rivers in Corsica, and to all of southern Europe (continental France, Spain, Portugal, Italy, and Greece) where the snail intermediate host is present.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

et al. 2016

View full text Add to dashboard Cite

We present a case of acute schistosomiasis acquired in Corsica after bathing in the Cavu River during the summer of 2015. The diagnosis was made following epidemiological, laboratory and serological assessments. After a previous outbreak of urogenital schistosomiasis during the summer of 2013, when more than 120 infections were diagnosed, this further case indicates transmission was still effective in 2015, thus suggesting a permanent presence of schistosomiasis in Corsica.We report a case of schistosomiasis acquired in 2015 in Corsica, indicating that permanent transmission of this helminthiasis has been established on the island. Case descriptionOn 11 September 2015, a person in their 40s presented to the Consultation Board at the Infectious and Tropical Disease Department of Toulouse University Hospitals in France with a 15-day history of diffuse abdominal pain, headache and asthenia. The patient had no fever, and physical examination was unremarkable. In particular, the patient neither displayed any skin rash nor complained of pruritus. The white blood cell count was 6.0 × 10 9 /L, within the normal range (4.0-10.0 × 10 9 cells/L), but a blood eosinophilia (3.2 × 10 9 cells/L, normal range: < 0.5 × 10 9 cells/L) was observed by differential count. Biochemical tests of liver function found several abnormalities, namely a serum alanine aminotransferase level at 140 UI/L (normal range: 0-40 UI/L) and a gamma-glutamyl transferase level at 323 IU/L (normal range: 0-60 IU/L). Aspartate aminotransferase and total bilirubin levels were within the normal range. C-reactive protein was 11.7 mg/L (normal value: < 5 mg/L).By serology, the patient tested negative for cytomegalovirus, Epstein-Barr virus, hepatitis A, B and C, and Leptospira infections. Serodiagnostics of ascariasis, alveolar and cystic echinococcoses, fascioliasis, filariases, strongyloidiasis, trichinellosis and schistosomiasis were negative. The ELISA result for schistosomiasis (expressed as a ratio), although negative with a ratio of 0.770, was close to the cut-off value of 1.0. Schistosomiasis serology relied upon commercial ELISA kits (Bordier Affinity Products, Crissier, Switzerland) and indirect haemagglutination assay (IHA) (Fumouze Diagnostics, Levallois-Perret, France), which are both screening tests using Schistosoma mansoni extracts as antigen.Because an aetiological diagnosis was not reached, the patient attended a further consultation on 24 September. The clinical picture remained unchanged, but blood eosinophilia decreased to 2 × 10 9 cells/L. By that time, specific laboratory examinations for urogenital schistosomiasis had been carried out because of the previous ELISA result and also because the patient informed us of their vacation in Corsica in summer 2015. Urinalysis was normal, and microscopic search for Schistosoma haematobium eggs remained negative. Serology was positive, with an ELISA ratio of 2.65 (cutoff: 1.0). The IHA result (expressed as a titre of dilution) was 160 (cut-off: 160). These results were checked by a commercial West...

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Schistosomiasis has not been described as endemic in Corsica so far; however, Bulinus truncatus, the vector (snail) of S. haematobium is known to be endemic in some areas of south Europe, including Corsica, where it transmitted zoonotic S. bovis, which in humans may cause skin irritation (cercarial dermatitis) due to the unsuccessful skin penetration of zoonotic cercariae [5][6][7]. Generally, Bulinus spp.…”

Section: Discussionmentioning

confidence: 99%

Schistosoma haematobium infections acquired in Corsica, France, August 2013

et al. 2014

View full text Add to dashboard Cite

A 12 year-old boy in Germany developed urinary schistosomiasis in January 2014. He had bathed in rivers in south-eastern Corsica five months earlier. Before this case, human schistomiasis had not been reported on the island, although its vector, the snail Bulinus truncatus, locally transmitted the zoonotic Schistosoma bovis. The boy's father excreted S. haematobium ova that were not viable; the boy's three siblings had a positive serology against schistosomes.

show abstract

Environmental DNA for detecting Bulinus truncatus: A new environmental surveillance tool for schistosomiasis emergence risk assessment

et al. 2019

View full text Add to dashboard Cite

Under ongoing climate changes, the development of large‐scale monitoring tools for assessing the risk of disease emergence constitutes an urging challenge. This is particularly the case for snail‐borne diseases such as the urogenital bilharziasis that emerged in Corsica and threat European countries. The expansion of this tropical disease mainly relies on the local presence of competent snail hosts such as Bulinus truncatus. Unfortunately, very little is known about the actual repartition of freshwater snails worldwide which makes new emergences difficult to predict. In this study, we developed two ready‐to‐use environmental DNA‐based methods for assessing the distribution of B. truncatus from water samples collected in the field. We used two approaches, a quantitative PCR (qPCR) and a droplet digital PCR (ddPCR) approach. We successfully detected B. truncatus in natural environments where the snail was previously visually reported. Our environmental DNA diagnostic methods showed a high sensitivity (≈60 DNA copy per mL of filtered water) and a high specificity to B. truncatus. Results obtained in qPCR and ddPCR were very similar. This study demonstrates that environmental DNA diagnostics tools enable a sensitive large‐scale monitoring of snail‐borne diseases hence allowing the delimitation of areas potentially threatened by urogenital schistosomiasis.

show abstract

Bullins et bilharzioses en Corse

Cited by 15 publications

References 0 publications

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

Schistosoma haematobium infections acquired in Corsica, France, August 2013

Environmental DNA for detecting Bulinus truncatus: A new environmental surveillance tool for schistosomiasis emergence risk assessment

Contact Info

Product

Resources

About