Schistosoma haematobium infections acquired in Corsica, France, August 2013

Holtfreter, Martha C.; Moné, Hélène; Müller-Stöver, Irmela; Mouahid, Gabriel; Richter, Joachim

doi:10.2807/1560-7917.es2014.19.22.20821

Cited by 82 publications

(59 citation statements)

References 7 publications

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“…Furthermore, the patient did not report any history of bathing in other Rivers in Corsica or staying in or travelling to classic or usual endemic areas for schistosomiasis. Previously, an outbreak of urogenital schistosomiasis had been identified in connection with bathing in the same river during the summer of 2013 [1][2][3][4][5]. That no schistosomiasis infections were observed in the 2014 summer is probably due to the fact that the French authorities prohibited bathing in the Cavu River.…”

Section: Discussionmentioning

confidence: 99%

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

et al. 2016

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We present a case of acute schistosomiasis acquired in Corsica after bathing in the Cavu River during the summer of 2015. The diagnosis was made following epidemiological, laboratory and serological assessments. After a previous outbreak of urogenital schistosomiasis during the summer of 2013, when more than 120 infections were diagnosed, this further case indicates transmission was still effective in 2015, thus suggesting a permanent presence of schistosomiasis in Corsica.We report a case of schistosomiasis acquired in 2015 in Corsica, indicating that permanent transmission of this helminthiasis has been established on the island. Case descriptionOn 11 September 2015, a person in their 40s presented to the Consultation Board at the Infectious and Tropical Disease Department of Toulouse University Hospitals in France with a 15-day history of diffuse abdominal pain, headache and asthenia. The patient had no fever, and physical examination was unremarkable. In particular, the patient neither displayed any skin rash nor complained of pruritus. The white blood cell count was 6.0 × 10 9 /L, within the normal range (4.0-10.0 × 10 9 cells/L), but a blood eosinophilia (3.2 × 10 9 cells/L, normal range: < 0.5 × 10 9 cells/L) was observed by differential count. Biochemical tests of liver function found several abnormalities, namely a serum alanine aminotransferase level at 140 UI/L (normal range: 0-40 UI/L) and a gamma-glutamyl transferase level at 323 IU/L (normal range: 0-60 IU/L). Aspartate aminotransferase and total bilirubin levels were within the normal range. C-reactive protein was 11.7 mg/L (normal value: < 5 mg/L).By serology, the patient tested negative for cytomegalovirus, Epstein-Barr virus, hepatitis A, B and C, and Leptospira infections. Serodiagnostics of ascariasis, alveolar and cystic echinococcoses, fascioliasis, filariases, strongyloidiasis, trichinellosis and schistosomiasis were negative. The ELISA result for schistosomiasis (expressed as a ratio), although negative with a ratio of 0.770, was close to the cut-off value of 1.0. Schistosomiasis serology relied upon commercial ELISA kits (Bordier Affinity Products, Crissier, Switzerland) and indirect haemagglutination assay (IHA) (Fumouze Diagnostics, Levallois-Perret, France), which are both screening tests using Schistosoma mansoni extracts as antigen.Because an aetiological diagnosis was not reached, the patient attended a further consultation on 24 September. The clinical picture remained unchanged, but blood eosinophilia decreased to 2 × 10 9 cells/L. By that time, specific laboratory examinations for urogenital schistosomiasis had been carried out because of the previous ELISA result and also because the patient informed us of their vacation in Corsica in summer 2015. Urinalysis was normal, and microscopic search for Schistosoma haematobium eggs remained negative. Serology was positive, with an ELISA ratio of 2.65 (cutoff: 1.0). The IHA result (expressed as a titre of dilution) was 160 (cut-off: 160). These results were checked by a commercial West...

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Section: Discussionmentioning

confidence: 99%

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

et al. 2016

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“…> La sphingosine 1-phosphate (S1P) est un lipide impliqué dans la régulation de la prolifération, la survie, la migration, et l'invasion cellulaires. Il intervient égale-ment dans l'angiogenèse [1]. La S1P est le produit de la phosphorylation de la sphingosine par les sphingosine kinases.…”

Section: Nouvelleunclassified

“…), génère la S1P qui peut alors être sécrétée et agir de façon extracellulaire. Elle se lie à l'un de ses cinq récepteurs (S1P [1][2][3][4][5] ), qui sont des récep-teurs couplés aux protéines G, induisant…”

Section: Nouvelleunclassified

“…Un foyer de bilharziose en France : une situation inédite En janvier 2014, un jeune garçon de 12 ans se présentait à l'hôpital de Düs-seldorf pour une hématurie 1 . Des oeufs de Schistosoma haematobium furent alors retrouvés dans ses urines [1].…”

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“…Des oeufs de Schistosoma haematobium furent alors retrouvés dans ses urines [1]. En 1 Présence de sang dans l'urine.…”

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Changements globaux et infections parasitaires à mollusques vecteurs

et al. 2015

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Environmental DNA for detecting Bulinus truncatus: A new environmental surveillance tool for schistosomiasis emergence risk assessment

et al. 2019

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Under ongoing climate changes, the development of large‐scale monitoring tools for assessing the risk of disease emergence constitutes an urging challenge. This is particularly the case for snail‐borne diseases such as the urogenital bilharziasis that emerged in Corsica and threat European countries. The expansion of this tropical disease mainly relies on the local presence of competent snail hosts such as Bulinus truncatus. Unfortunately, very little is known about the actual repartition of freshwater snails worldwide which makes new emergences difficult to predict. In this study, we developed two ready‐to‐use environmental DNA‐based methods for assessing the distribution of B. truncatus from water samples collected in the field. We used two approaches, a quantitative PCR (qPCR) and a droplet digital PCR (ddPCR) approach. We successfully detected B. truncatus in natural environments where the snail was previously visually reported. Our environmental DNA diagnostic methods showed a high sensitivity (≈60 DNA copy per mL of filtered water) and a high specificity to B. truncatus. Results obtained in qPCR and ddPCR were very similar. This study demonstrates that environmental DNA diagnostics tools enable a sensitive large‐scale monitoring of snail‐borne diseases hence allowing the delimitation of areas potentially threatened by urogenital schistosomiasis.

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Schistosoma haematobium infections acquired in Corsica, France, August 2013

Cited by 82 publications

References 7 publications

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015

Changements globaux et infections parasitaires à mollusques vecteurs

Environmental DNA for detecting Bulinus truncatus: A new environmental surveillance tool for schistosomiasis emergence risk assessment

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