Brucellosis vaccines based on the open reading frames from genomic island 3 of Brucella abortus

Gómez, Leonardo A; Alvarez, Francisco I; Betancur, Daniel; Oñate, Ángel

doi:10.1016/j.vaccine.2018.04.014

Cited by 10 publications

(7 citation statements)

References 71 publications

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“…A cocktail lysate of S19 and RB51 was also tested as an immune-therapy to treat the bracelet infected cattle [ 114 ]. DNA vaccines have also been tested and show promising results when compared with S19 and RB51; however, several boosters were required to achieve the desired immunity [ 127 , 128 ]. In China, the S2 vaccine is widely in practice; however, it triggers an innate immune response and causes increased inflammation [ 129 ].…”

Section: Vaccination Against Brucellosismentioning

confidence: 99%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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Brucellosis is one of the most common contagious and communicable zoonotic diseases with high rates of morbidity and lifetime sterility. There has been a momentous increase over the recent years in intra/interspecific infection rates, due to poor management and limited resources, especially in developing countries. Abortion in the last trimester is a predominant sign, followed by reduced milk yield and high temperature in cattle, while in humans it is characterized by undulant fever, general malaise, and arthritis. While the clinical picture of brucellosis in humans and cattle is not clear and often misleading with the classical serological diagnosis, efforts have been made to overcome the limitations of current serological assays through the development of PCR-based diagnosis. Due to its complex nature, brucellosis remains a serious threat to public health and livestock in developing countries. In this review, we summarized the recent literature, significant advancements, and challenges in the treatment and vaccination against brucellosis, with a special focus on developing countries.

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Section: Vaccination Against Brucellosismentioning

confidence: 99%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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“…Monitoring oxidative stress, blood biochemistry, and defense system profile (antioxidant enzymes) are important tools to lower the adverse impacts of oxidative stress in animals. Studies have indicated that free radicals affect steroidogenesis, apoptosis, lipid peroxidation, and folliculogenesis leading to disorders in embryo preimplantation and infertility in animals [43][44][45]. Therefore, estimation of blood bio-chemistry, oxidative stress, and endogenous antioxidants are considered critical factors in initiating different molecular mechanisms during infectious diseases [46].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hematological, Oxidative Stress, and Antioxidant Profile in Cattle Infected with Brucellosis in Southern Punjab, Pakistan

Hussain

Khan

Jamal

et al. 2022

BioMed Research International

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Brucellosis is a well-known and harmful zoonotic disease that poses a severe threat to public health and wild and dairy animals. Due to a lack of monitoring and awareness, disease incidence has increased. Therefore, this study was conducted for the first time to ascertain the status of seroprevalence of brucellosis, hematological, oxidative stress, and antioxidant enzymes in different breeds of cattle reared under tropical-desert conditions in Pakistan. This study comprised 570 cattle of different breeds. We recorded some epidemiological traits, including age and gender. The blood samples were obtained from all the cattle, screened with RBPT, and then confirmed by ELISA and PCR. The results recorded an overall 11.75%, 10.7%, and 9.64% prevalence of brucellosis based on RBPT, ELISA, and PCR. We obtained nonsignificant results in different age and sex groups of cattle. The results showed significantly ( P ≤ 0.05 ) lower values of erythrocyte counts, hemoglobin quantity, hematocrit, lymphocytes, and monocytes in infected cases. The results showed that the total leukocyte and neutrophil cells significantly ( P ≤ 0.05 ) increased. The lipid peroxidation parameters (MDA- and NO-scavenging activity of erythrocyte) increased significantly ( P ≤ 0.05 ) in infected cattle, whereas significantly reduced antioxidant enzymes like SOD, RGSH, and CAT were. Similarly, significantly lower serum albumin levels and total serum proteins were recorded in infected cattle.

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“…The antigens coding by these genes were responsible for bacterial virulence and intracellular survival of B. abortus in the host. When tested in mouse model, the DNA vaccine induced cytotoxic T cell and Th1 type immune responses, indicating the protective immune potential of such vaccine via immune cells (Gomez et al 2018).…”

Section: Vaccinationmentioning

confidence: 99%

Bovine brucellosis – a comprehensive review

Khurana

Sehrawat

Tiwari

et al. 2021

Veterinary Quarterly

137

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Brucellosis is a zoonotic disease of great animal welfare and economic implications worldwide known since ancient times. The emergence of brucellosis in new areas as well as transmission of brucellosis from wild and domestic animals is of great significance in terms of new epidemiological dimensions. Brucellosis poses a major public health threat by the consumption of non-pasteurized milk and milk products produced by unhygienic dairy farms in endemic areas. Regular and meticulous surveillance is essentially required to determine the true picture of brucellosis especially in areas with continuous high prevalence. Additionally, international migration of humans, animals and trade of animal products has created a challenge for disease spread and diagnosis in non-endemic areas. Isolation and identification remain the gold standard test, which requires expertise. The advancement in diagnostic strategies coupled with screening of newly introduced animals is warranted to control the disease. Of note, the diagnostic value of miRNAs for appropriate detection of B. abortus infection has been shown. The most widely used vaccine strains to protect against Brucella infection and related abortions in cattle are strain 19 and RB51. Moreover, it is very important to note that no vaccine, which is highly protective, safe and effective is available either for bovines or human beings. Research results encourage the use of bacteriophage lysates in treatment of bovine brucellosis. One Health approach can aid in control of this disease, both in animals and man.

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Brucellosis vaccines based on the open reading frames from genomic island 3 of Brucella abortus

Cited by 10 publications

References 71 publications

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

Evaluation of Hematological, Oxidative Stress, and Antioxidant Profile in Cattle Infected with Brucellosis in Southern Punjab, Pakistan

Bovine brucellosis – a comprehensive review

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