Brown Adipose Tissue and Thermoregulatory Heat Production in the Rat

Donhoffer, S; Sárdy, F.; Szegvari, G

doi:10.1038/203765b0

Cited by 38 publications

(13 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The response was independent of the hyperglycaemic action of the hormone. As brown adipose tissue is a site of heat production in adult rats during cold exposure (Donhoffer, Sardy & Szegvari, 1964) it is possible that the response that Davidson et al (1957) observed was due to the direct action of glucagon on brown adipose tissue. To our knowledge, an acute calorigenic response to corticotrophin has not been reported previously.…”

Section: Discussionmentioning

confidence: 99%

The effect of propranalol on the calorigenic response in brown adipose tissue of new‐born rabbits to catecholamines, glucagon, corticotrophin and cold exposure

Heim¹,

Hull²

1966

The Journal of Physiology

118

View full text Add to dashboard Cite

(i.v. 4,uzg/kg. min for 10 min) caused a large increase in the rate of the rabbit's oxygen consumption and in blood flow through its brown adipose tissue. These responses, which reached a maximum within 10 min from the start of the infusion, were not blocked by propranalol (1 or 5 mg/kg).4. Infusion of corticotrophin (i.v. 1 i.u./kg.min for 10 min) also caused a large increase in the rate of oxygen consumption of new-born rabbits. The response reached a maximum about 20 min from the start of the infusion and it was not blocked by propranalol (5 mg/kg).5. These results support the conclusion that noradrenaline is released at sympathetic endings in brown adipose tissue and that the increase in blood flow caused by noradrenaline is secondary to its metabolic action on the tissue. They also suggest the possibility that glucagon and corticotrophin may act directly on brown adipose tissue and stimulate heat production during cold exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of propranalol on the calorigenic response in brown adipose tissue of new‐born rabbits to catecholamines, glucagon, corticotrophin and cold exposure

Heim¹,

Hull²

1966

The Journal of Physiology

118

View full text Add to dashboard Cite

show abstract

“…In our rats, exogenous noradrenaline induced an increase in oxygen consumption similar to that induced by exposure to 15°C. These animals, therefore, could be expected to activate this thermogenic mechanism during cold exposure, for the rat appears to use its capacity for non-shivering thermogenesis during acute cold exposure (Davis et al 1959;Donhoffer et al 1964;Sz6kely et al 1970;Portet et al 1976). …”

Section: Discussionmentioning

confidence: 99%

The control of shivering and non‐shivering thermogenesis in the rat.

Banet¹,

Hensel²

1977

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The effect of intraperitoneal administration of propranolol (4, 8 and 12 mg/kg) on colonic temperature was studied in twelve rats during exposure to ambient temperatures of 30, 15 and 50 C.2. At 300 C, propranolol had no effect on colonic temperature; at 15 and 50 C, however, 4 mg propanolol/kg induced a fall in colonic temperature of about 0.80 C, whereas 8 and 12 mg propanolol/kg induced a fall of about 1.5-2-00 C.3. Assuming that the temperature regulation system of the rat has a proportional controller and that the effect of propranolol was due to the blockade of non-shivering thermogenesis, the results are interpreted as showing that shivering is activated only when heat loss exceeds the capacity for non-shivering thermogenesis.

show abstract

“…Zirm (1956) found that after excision of 50 % of the brown adipose tissue hedgehogs died during hibernation if exposed to very low environmental temperatures. Recently it has been shown that brown adipose tissue in hibernating animals during arousal (Smith & Hock, 1963;Smalley & Dryer, 1963) and in the adult rat on exposure to cold (Donhoffer, Sardy, Szegvari, 1964) is a site of heat production. However, the contribution of brown adipose tissue to the total heat production of either the rat on cold exposure or the hibernating animal during arousal is not known.…”

Section: Discussionmentioning

confidence: 99%