The control of shivering and non‐shivering thermogenesis in the rat.

Banet, M; Hensel, Herbert

doi:10.1113/jphysiol.1977.sp011921

Cited by 28 publications

(8 citation statements)

References 15 publications

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“…Acute cold exposure at 4°C induced a twofold increase in energy expenditure. This is in agreement with data from the literature (Banet and Hensel 1977;Griggio 1982).…”

Section: Figsupporting

confidence: 93%

In situ lipolysis measured by in vivo microdialysis during acute cold exposuren situ lipolysis measured by in vivo microdialysis during acute cold exposure

Cimmino¹,

Bukowiecki²,

Géloën³

1997

Can. J. Physiol. Pharmacol.

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The lipolytic responsiveness of interscapular white adipose tissue was measured, in male Sprague-Dawley rats (355 +/- 12 g, n = 7), by microdialysis before, during, and after an acute cold exposure (1 h at 4 degrees C). Microdialysis probes were perfused with standard Krebs-Ringer buffer to determine basal and stimulated rates of lipolysis. The concentration of glycerol in the dialysate was measured and considered as the lipolytic index. During the experiment, energy expenditure was measured by indirect calorimetry. Cold exposure at 4 degrees C doubled energy expenditure. At the same time, it resulted in a 2.7-fold increase in glycerol release. The present study shows that microdialysis is a perfectly adapted tool to investigate in vivo regulation of adipose tissue on awake, unrestrained rats.

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“…Acute cold exposure at 4°C induced a twofold increase in energy expenditure. This is in agreement with data from the literature (Banet and Hensel 1977;Griggio 1982).…”

Section: Figsupporting

confidence: 93%

In situ lipolysis measured by in vivo microdialysis during acute cold exposuren situ lipolysis measured by in vivo microdialysis during acute cold exposure

Cimmino¹,

Bukowiecki²,

Géloën³

1997

Can. J. Physiol. Pharmacol.

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“…Warming the spinal cord, for example, suppressed the increase in oxygen consumption induced by exposure to mild cold stress (Banet & Hensel, 1976c). This must have been due to the suppression of non-shivering thermogenesis since in the rat (Banet & Hensel, 1977) and in the guinea-pig (Bruck & Wiinnenberg, 1970) cold exposure first induces this form of heat production. Furthermore, prolonged and repetitive cooling of the spinal cord of the rat led to an increase in the capacity for non-shivering thermogenesis (Banet & Hensel, 1976b).…”

Section: Introductionmentioning

confidence: 99%

The central control of shivering and non‐shivering thermogenesis in the rat.

Banet¹,

Hensel²,

Liebermann³

1978

The Journal of Physiology

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SUMMARY1. To test whether the preoptic area controls only non-shivering and the spinal cord only shivering thermogenesis, ten rats were chronically implanted with a preoptic and a spinal cord thermode each. The following were then studied: (a) the effect of propranolol (8 mg/kg. hr) on the metabolic response to cooling the preoptic area, and the spinal cord, (b) the effect of exogenous noradrenaline (0.5 mg/kg) on the metabolic response to cooling the preoptic area, and the spinal cord, and (c) the effect of warming the preoptic area on the metabolic response to cooling the spinal cord, and vice versa.2. Administration of propranolol inhibited the metabolic response to cooling each of the thermosensitive areas, but the response to cooling the preoptic area was more strongly inhibited than that to cooling the spinal cord.3. Administration of exogenous noradrenaline did not prevent the metabolic response to cooling either the preoptic area or the spinal cord.4. Warming the spinal cord completely inhibited the metabolic response to cooling the preoptic area, and warming the preoptic area fully inhibited the metabolic response to cooling the spinal cord.5. It is concluded that exogenous noradrenaline underestimates the capacity for non-shivering thermogenesis, and that both thermosensitive areas can control both forms ofthermogenesis, but that the preoptic area threshold of non-shivering thermogenesis is probably lower than that of shivering, while the spinal cord threshold of shivering is probably lower than that of non-shivering thermogenesis.

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“…Cold resistant A. russatus when exposed to an ambient temperature of 6°C and treated with propranolol (4.5 mg/Kg) became hypothermic very rapidly, and no recording of any shivering was observed 7 . In mammals, propranolol is not known to interfere with shivering 8 . No shivering was observed in these mice when exposed to cold and not treated with propranolol.…”

Section: Introductionmentioning

confidence: 79%