Bronchiolitis obliterans organizing pneumonia: The clinical and radiological features of seven cases and a review of the literature

Flowers, J.R.; Clunie, Gavin; Burke, M. Nicholas; Constant, Olivia

doi:10.1016/s0009-9260(05)80993-6

Cited by 65 publications

(52 citation statements)

References 14 publications

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“…[11]. Typical radiographic findings of COP and secondary OP are patchy bilateral peripheral alveolar opacities, often flitting in locality [11,12]. Chest CT scans principally show focal subpleural consolidation and ground glass shadowing is commonly present.…”

Section: Discussionmentioning

confidence: 99%

Co-existence of organising pneumonia in a patient with Mycobacterium Avium Intracellulare pulmonary infection

Jones

Dawson

Evans

et al. 2016

Monaldi Arch Chest Dis

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Non-tuberculous mycobacterias (NTMs) have many clinical manifestations in humans, depending on the underlying immunological status. We present a patient with Mycobacterium avium intracellulare pulmonary infection and co-existing, biopsy proven non-granulomatous organising pneumonia in distinct regions within the lungs. Treatment consisting of anti-mycobacterial therapy and corticosteroids led to clinico-radiological resolution. This case represents a potential broader clinico-pathological manifestation of Mycobacterium avium intracellulare.

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Section: Discussionmentioning

confidence: 99%

Co-existence of organising pneumonia in a patient with Mycobacterium Avium Intracellulare pulmonary infection

Jones

Dawson

Evans

et al. 2016

Monaldi Arch Chest Dis

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“…However, these patients showed severe obstructive pulmonary defects and mosaic patterns on HRCT, and the negative biopsy results were probably due to a recognised sampling problem. The patchy distribution of the disease can result in sampling error, with false negative results [17]. A cell-mediated immune mechanism may have occurred in case 2, who exhibited allergic contact dermatitis and delayed-type hypersensitivity to butter flavourings on patch testing, as well as severe fixed airflow limitation.…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans syndrome in popcorn production plant workers

Akpinar‐Elci¹,

Travis²,

Lynch³

et al. 2004

Eur Respir J

191

177

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Following sentinel case recognition, an excess of fixed airways obstruction was found among current workers in a microwave popcorn plant associated with butter flavouring exposures.In order to characterise the clinical presentation of sentinel cases, the medical records of sentinel cases were reviewed, interviews conducted and serial spirometric testing performed.Cases worked in microwave popcorn production, and five of the nine cases had mixed flavourings. Most had never smoked or smoked minimally. Cases showed onset of cough, shortness of breath and wheezing 5 months to 9 yrs after starting work at the popcorn plant. Initial forced expiratory volume in one second ranged 14.0-66.8% of the predicted value. Eight high-resolution computed tomography scans showed marked bronchial wall thickening and mosaic attenuation with air trapping. Open lung biopsy results were consistent with, or diagnostic of, constrictive bronchiolitis in two of three cases. Five cases are on lung transplantation waiting lists. After leaving employment, nearly all cases experienced stabilisation of their lung function within 2 yrs.Astute clinicians can help identify new causes of airways obstruction by alerting public health authorities to unexplained disease cases occurring in groups of workers.

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“…It consists of an increase in lymphocytes (20-40%), neutrophils (,10%) and eosinophils (,5%) with the level of lymphocytes higher than that of eosinophils [17,94,97,110,[162][163][164]. A markedly elevated percentage of eosinophils (.25%) may suggest an overlap with idiopathic chronic eosinophilic pneumonia [18,96,99,109,138]. The finding of a few plasma cells and/or mast cells is remarkable in COP.…”

Section: Biological Featuresmentioning

confidence: 99%

“…A peculiar iatrogenic organising pneumonia is one that is ''primed'' by radiation therapy to the breast (tangential field radiotherapy) [109,[290][291][292][293][294][295][296][297][298][299][300]. It closely resembles COP and clearly differs from radiation pneumonitis, especially because it may involve nonirradiated areas of the lung and possibly be migratory.…”

Section: Determined Causes Of Organising Pneumoniamentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

European Respiratory Journal

477

466

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Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

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Bronchiolitis obliterans organizing pneumonia: The clinical and radiological features of seven cases and a review of the literature

Cited by 65 publications

References 14 publications

Co-existence of organising pneumonia in a patient with Mycobacterium Avium Intracellulare pulmonary infection

Co-existence of organising pneumonia in a patient with Mycobacterium Avium Intracellulare pulmonary infection

Bronchiolitis obliterans syndrome in popcorn production plant workers

Cryptogenic organising pneumonia

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