Cryptogenic organising pneumonia

Abstract

Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation

“…[8][9][10][11][12] However, it frequently recurs and repeatedly deteriorates. 2,3,5,9 Taking the fact into consideration, COP/BOOP might affect survivals in a later phase of allogeneic HCT rather than that in an early phase. In fact, the NRM curves of the COP/ BOOP group seemed to increase linearly, and the 3-year NRM remained high even focusing on the longer survivors, whereas the 3-year NRM in the control group tended to decrease as the longer survivors were focused on.…”

“…2,3,5 As PBSC transplantation (PBSCT) from unrelated donors was not available in Japan during the evaluation period, HCT was categorized into four groups as follows: related BMT, related PBSCT, unrelated BMT and unrelated cord blood transplantation (CBT). The diagnosis and severity of GVHD were reported based on the clinical grading scores.…”

“…[2][3][4] COP/BOOP is characterized by fever with nonproductive coughing and the presence of granulation tissue within the alveolar ducts and alveoli, leading to an intraluminal organizing pneumonia. 2,3,[5][6][7] The incidence of COP/ BOOP after HCT has been reported to range from 1 to 10%, and it appears at a median of 100 days or later after HCT. 2,3 Although COP/BOOP has been reported to respond to steroid treatment, [8][9][10][11][12] recurrence is often observed and prolonged steroid treatment is frequently required.…”

“…2,3 Although COP/BOOP has been reported to respond to steroid treatment, [8][9][10][11][12] recurrence is often observed and prolonged steroid treatment is frequently required. 2,3,5,9 COP/BOOP occasionally progresses to thoracic air-leak syndrome and can be refractory to treatment. 13 Therefore, it is important to elucidate the risks for the development of COP/BOOP.…”

Neumonía criptogénica organizada como diagnóstico diferencial de neumonía que no responde a tratamiento: Report of one case

“…Una de las causas de la NNRT es la neumonía organizada, una entidad poco conocida, subdiagnosticada y que puede ser secundaria a múltiples causas, siendo de diagnóstico fundamentalmente histopatológico 4 . Cuando no se logra identificar una etiología se denomina neumonía organizada criptogénica (Cryptogenic Organizing Pneumonia: COP).…”