High-rate anaerobic treatment has emerged as a viable alternative for the treatment of many industrial and municipal wastewaters. A number of different process options have been reduced to practice, although some configurations are clearly more well developed than others. One common thread that links these various processes (principally the Anaerobic Filter, Upflow Anaerobic Sludge Blanket and Expanded/Fluidized Bed Reactors), is the ability to effectively separate solids and hydraulic retention times. This permits design to be based upon the degradative capacity of the anaerobes, not growth rate and results in reduction of treatment times from days (typical for conventional digester systems) to hours. This article compares and contrasts the principles of start-up and operation of these different high-rate anaerobic systems based upon laboratory research and full-scale operating experience gained over the past two decades. The application of anaerobic processes for treatment of certain toxic and hazardous waste streams is just beginning. The limited work performed to date and anticipated future needs for process monitoring and control are also presented in this article.
Analysis of the Muderong Shale from the Carnarvon Basin suggests the shale is dominated by interstratified illite–smectite with a high percentage of illite interlayers. Capillary pressure measurements indicate that gas columns of c . 250 m could be sealed by such shale, although the choice of drying method used does influence the accuracy of this calculation. Freeze drying yielded the most consistent threshold pressure results, whereas air drying and vacuum drying showed a greater range of values. Similar calculations in regard to carbon dioxide sequestration indicate column heights of between 550 m and 750 m could be retained. Column height variation is primarily dependent on the contact angle of supercritical carbon dioxide with shale. Microstructurally, the shale is clay supported, exhibiting differential compaction of clays around more rigid grains and containing numerous high aspect ratio discontinuous fractures. These fractures do not affect the capillary properties of the shale, even when injection is fracture-parallel, suggesting they are unlikely to influence reservoir-scale fluid-flow properties. Comparison of the Muderong Shale laboratory data with hydrocarbon column heights from Carnarvon Basin discoveries indicate that top seal failure by capillary breakthrough is unlikely given the maximum lengths of hydrocarbon columns encountered to date. Potential for top seal failure is more likely to be influenced by formation integrity, pore pressure and in situ stress conditions.
BackgroundPatients with idiopathic pulmonary fibrosis (IPF) frequently develop a dry, irritating cough which often proves refractory to anti-tussive therapies. The precise pathogenetic mechanisms responsible for this cough are unknown. We hypothesised that changes in nerves modulating mechanical sensitivity in areas of interstitial fibrosis might lead to enhanced cough response to mechanical stimulation of the chest in IPF.MethodsWe studied 27 non-smoking subjects with IPF (63% male), mean (SD) age 71.7 (7) years and 30 healthy non-smokers. Quality of life (Leicester Cough Questionnaire), cough symptom scores and cough severity scores (visual analog scales) were recorded. Percussion stimulation was applied over the posterior lung base, upper anterior chest and manubrium sternum at sequential frequencies (20 Hertz (Hz), 40 Hz and 60 Hz) for up to 60 seconds and repeated twice at two minute intervals. The number of subjects achieving two and five-cough responses, total cough counts and cough latency were recorded. In separate experiments, the effect of mechanical stimulation on the pattern of breathing was determined in eight IPF subjects and five control subjects.ResultsIn patients with IPF, we demonstrated strong correlations between subjective cough measurements, particularly the cough symptom score and Leicester Cough Questionnaire (r = -0.86; p < 0.001). Mechanical percussion induced a true cough reflex in 23/27 (85%) IPF subjects, but only 5/30 (17%) controls (p < 0.001). More patients with IPF reached the two-cough response at a lower frequency (20 Hz) posteriorly than at other positions. Highest mean cough totals were seen with stimulation at or above 40 Hz. Mechanical stimulation had no effect on respiratory rate but increased tidal volume in four (50%) subjects with IPF, particularly at higher frequencies. It was associated with increased urge to cough followed by a true cough reflex.ConclusionsThis study demonstrates that patients with IPF show enhanced cough reflex sensitivity to mechanical stimulation of the chest wall whilst normal individuals show little or no response. The observation that low frequency stimulation over the lung base, where fibrosis is most extensive, induces cough in more patients than at other sites supports the hypothesis that lung distortion contributes to the pathogenesis of cough in IPF.
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