Bromoderma in a pituitary adenoma patient treated with bromocriptine

Diffuse vegetating bromoderma

“…9,10 Local therapies include topical corticosteroids and antiseptic measurements. 2,4,6 Our case highlights that bromoderma has still to be considered as a side effect of therapeutic interventions utilizing bromide-containing agents.…”

“…1,5 Besides antiepileptics, bromides can be found in other drugs, including butylscopolamine bromide, the inhalant anti-asthmatics containing ipratropium bromide, and mydriatic eye drops with scopolamine hydrobromide. 2,5,6 However, bromine might also be used as an ingredient in foodstuff, pesticide, photographic films and permanent hairwaving solutions. 1,7,8 The pathogenesis of bromoderma is still under debate.…”

“…5 Treatment mainly relies on the withdrawal of the offending drug. 2,4,6 In addition, diuretics, such as furosemide and ethacrynic acid, could be administered because of their activity in accelerating bromide excretion through the kidneys. 9,10 Local therapies include topical corticosteroids and antiseptic measurements.…”

Disseminated vegetating infantile bromoderma: A dramatic response to systemic steroids

“…Some adjunctive drugs as diuretics (furosemide) and mannitol may be used to accelerate renal excretion of the bromide and help rapid resolution of cutaneous lesions. Systemic corticosteroids at a dose of 1‐2 mg/kg/day for 2‐3 weeks followed by a gradual withdrawal along a period of 1 month may be needed in severe or disseminated cases, particularly those presenting with vegetating lesions as was the case in our patient 6‐9 …”

“…Systemic corticosteroids at a dose of 1-2 mg/kg/day for 2-3 weeks followed by a gradual withdrawal along a period of 1 month may be needed in severe or disseminated cases, particularly those presenting with vegetating lesions as was the case in our patient. [6][7][8][9] Along with stoppage of the antispasmoic syrup, our patient received systemic prednisolone at a dose of 1 mg/kg/day that resulted in a dramatic response after 10 days as shown in Figures 2 and 3; and then gradually tapered along a period of 3 weeks. The dramatic response to systemic steroid in this case might be attributed to its marked antiinflammatory effect and the inhibition of the delayed hypersensitivity reaction induced by bromides as proposed by many authors.…”