Broadband Ultrasound Attenuation Predicts Fractures Strongly and Independently of Densitometry in Older Women

Bauer, Douglas C.; Glüer, Claus C.; Cauley, Jane A.; Vogt, Thomas; Ensrud, Kristine E.; Genant, Harry K.; Black, Dennis M.

doi:10.1001/archinte.1997.00440270067006

Cited by 627 publications

(186 citation statements)

References 27 publications

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“…In the follow up study blood sample was collected from study group after 3 months therapy. The bone mineral density was measured at the midshaft tibia by Quantitative Ultrasound method [6]. Estimation of intact osteocalcin by EASIA method [7].…”

Section: Methodsmentioning

confidence: 99%

BMD and Serum Intact Osteocalcin in Postmenopausal Osteoporosis Women

2010

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India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1) to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy (alendronate ? calcium ? vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited as control. Mean bone mineral density T score and Z score was significantly decreased (P \ 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of BMD-T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels were significantly increased (P \ 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P \ 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of osteoporosis and for monitoring responses to antiresorptive therapy.

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Section: Methodsmentioning

confidence: 99%

BMD and Serum Intact Osteocalcin in Postmenopausal Osteoporosis Women

2010

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“…Although it has been previously described that overweight children are skeletally advanced (37), recent studies have observed that a high proportion of children with distal forearm fractures are overweight and have lower bone mass and bone area density (38)(39)(40)(41)(42)(43)(44)(45)(46). Since physical activity is strongly osteogenic during growth, diminished participation in weight-bearing exercise by overweight children could have an adverse effect on bone development.…”

Section: Discussionmentioning

confidence: 99%

“…The predictive power of ultrasound measurements by means of broadband ultrasound attenuation with regard to femoral and spinal fracture risk has been demonstrated several times in osteoporotic women (22,(39)(40)(41). However, most of the studies performed to predict fractures using QUS have been done using ultrasound in the calcaneus (39)(40)(41).…”

Section: Discussionmentioning

confidence: 99%

Reduced Bone Mineralization in Adolescent Survivors of Malignant Bone Tumors: Comparison of Quantitative Ultrasound and Dual-Energy X-Ray Absorptiometry

Azcona

Burghard

Ruza

et al. 2003

Journal of Pediatric Hematology/Oncology

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Purpose: To assess bone mineralization in adolescents with bone tumors at remission using quantitative digital ultrasound (QUS) and dual-energy x-ray absorptiometry (DEXA), and to compare the bone mineralization values obtained by both methods. Methods:Patients studied were 36 adolescents (21 boys, 15 girls) who had completed treatment of a bone tumor at the University Hospital of the University of Navarra (Pamplona, Spain). QUS was performed at the distal metaphysis of the proximal phalanxes of the last four fingers of the nondominant hand. A DBM Sonic 1200 Ultrasound densitometer was used. DEXA measurements were made at the lumbar spine (vertebrae L1-L4) using the Hologic QDR 4500 W device. Calcium and vitamin D daily intake and grade of physical activity were recorded.Results: Mean age at bone mineralization determination was 19.11 years. Disease-free survival was 4.97 years. Decreased bone mineralization was observed by both methods. Bone mineralization absolute values measured by QUS and DEXA were significantly correlated. The sensitivity, specificity, diagnostic accuracy, and positive and negative predictive values of QUS for predicting osteopenia were 36.4%, 80.0%, 66.7%, 44.4%, and 74.1%, respectively. Daily vitamin D intake was below the recommended dietary allowances.Conclusions: Adolescents in remission from bone tumors have low bone mineralization determined by DEXA or QUS.

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“…In all these studies, QUS is a good predictor or discriminator of hip or non-spine fractures. 9,45,[47][48][49][50][51][52][53] In a meta-analysis of QUS and fractures, Marín et al reported the strength of association between QUS with non-spinal fractures to be similar to axial or peripheral BMD measurements. However, QUS was shown to be inferior to the association between BMD measured at the hip and hip fracture.…”

Section: Fracture Discriminationmentioning

confidence: 99%