Quantitative ultrasound and bone health

Knapp, Karen

doi:10.1590/s0036-36342009000700005

Cited by 19 publications

(17 citation statements)

References 107 publications

(124 reference statements)

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“…Some authors suggested that these parameters are more useful to determine subjects with diminished bone health status. 26 The stiffness index was introduced to measure bone fragility and it is defined as a combination of normalized SOS and BUA 14 Stiffness index was calculated by the following equation:…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

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<p>The Relation Between Calcaneus Stiffness Index as a Measure of Bone Density and Body Mass Index in an Egyptian Cohort</p>

Ali

Said

Adly

et al. 2020

JMDH

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Background: Obesity and osteoporosis are two conditions that are associated with morbidity and mortality; there is contradictory evidence regarding this association. Purpose: The aim of the current study was to explore further the association between obesity and calcaneus stiffness index (CSI), as a measure of bone density, in a communitybased cross-sectional study in an Egyptian population. Methods: A cross-sectional study was conducted among active subjects, aged ≥20 years old, over one year. CSI was measured by Quantitative ultrasound (QUS), in addition; QUS T-score and Z-score of the non-dominant heel scan were recorded. Results: Two hundred and eighty participants were recruited; 7 subjects were excluded because of Z score more than −2, mean age was 61 (± 11.9) years, and mean BMI was 29.7 (±5.6). Female participants were 77.7%, with mean of age 60.3 (± 11.6); and age range 20-82 years. Male participants were 22.3%, with mean of age 63.6 (± 12.7); and age range 30-80 years. Older subjects (>55 years) had significantly lower CSI and worse T-score than the younger subjects (P < 0.001 for both). In the younger age group, BMI was not significantly associated with CSI, even after adjustment for gender (P= 0.52). However, in the older age group, BMI was significantly associated with stiffness index (P= 0.049, O.R.= 1.73), even after adjustment for gender (P= 0.041, O.R.= 1.7). Conclusion: Compared to young subjects, older subjects (≥55 years) had significantly lower bone strength as measured by CSI, and their BMI was significantly positively associated with bone density. In younger people (<55 years), BMI was not associated with bone strength.

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Section: Anthropometric Measurementsmentioning

confidence: 99%

“…28 The majority of published literature on QUS has focused on the calcaneal site as it has a high metabolic activity and reflecting spine demineralization pattern. 26 Ultrasound BMD was measured by a portable ultrasound bone densitometer (GE healthcare -Achilles, USA)…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

<p>The Relation Between Calcaneus Stiffness Index as a Measure of Bone Density and Body Mass Index in an Egyptian Cohort</p>

Ali

Said

Adly

et al. 2020

JMDH

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“…In the case of SOS, the coefficient of variations (precision values) tend to be better in cortical bone compared to trabecular bone due to increased speed of sound waves in cortical bone. Similarly, BUA precision also appears to be poorer than its corresponding SOS precision in the same devices (60).…”

mentioning

confidence: 93%

Clinical utilities of quantitative ultrasound in osteoporosis associated with inflammatory rheumatic diseases

Naganathan

et al. 2018

Quant. Imaging Med. Surg.

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Secondary osteoporosis is an important co-morbidity related to inflammatory rheumatic diseases that is attributed to several factors including inflammatory cytokines, inactivity and glucocorticoid treatment.Quantitative ultrasound (QUS) has been utilized in osteoporosis research due to its detectability of bone density as well as bone quality. The current narrative review is to address the potential utilities of QUS in secondary osteoporosis of inflammatory rheumatic diseases, focusing on the clinical aspects of QUS in these diseases, based on the conformity of QUS with dual emission X-ray absorptiometry (DXA), the relationship with disease characteristics, and its capability of fracture prediction. Although limited data demonstrate that QUS had moderate to strong correlation with DXA, and might be useful as a potential imaging tool to screen for osteoporosis, further research is still required for QUS to be utilized effectively for the best outcome in these patients with rheumatic diseases.

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“…Dual energy X-ray absorptiometry (DXA) measures bone mineral density (BMD), and is currently the key assessment tool for diagnosing osteoporosis [6]. However, being a 2-dimensional measure, BMD does not su ciently explain variance in fracture outcomes amongst individuals with similar BMD measures [7][8][9], thus additional bone measures may be useful.…”

Section: Introductionmentioning

confidence: 99%

“…However, being a 2-dimensional measure, BMD does not su ciently explain variance in fracture outcomes amongst individuals with similar BMD measures [7][8][9], thus additional bone measures may be useful. Quantitative heel ultrasound (QUS) is a radiation-free, portable, non-invasive, inexpensive screening method to assess bone quality [6], measuring 3dimensional parameters such as bone structure and elasticity to explain variance in bone strength [10,11]. Trabecular bone in sites such as the vertebral body and the calcaneus is more susceptible to the effects of altered metabolism [12].…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant Use and Bone Health in a Population-based Study of Men and Women: Cross-sectional Data from the Geelong Osteoporosis Study.

Chandrasekaran

Pasco

Stuart

et al. 2020

Preprint

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Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women.Methods: Data from 1996 people, 926 men (age:24-73y) and 1070 women (21-94y) participating in the Geelong Osteoporosis Study were included. Bone mineral density (BMD, g/cm2) of the PA-spine and total hip was measured using dual-energy X-ray absorptiometry (Lunar). Bone quality was determined using quantitative heel ultrasound (QUS). Anthropometry was conducted and socioeconomic status was determined. Medication and lifestyle information was obtained via questionnaire. Linear regression was used to test associations between anticonvulsant use and bone health before and after adjustment for potential confounders. Results: Seventeen (1.8%) men and 20 (1.9%) women reported anticonvulsant use. In men, anticonvulsant users had 9.1% lower adjusted mean BMD at the spine and hip compared to non-users. Body mass index (28.5 kg/m2) was an effect modifier at the spine. Anticonvulsant users also had 1.8% lower speed of sound (SOS), 10.6% lower broadband ultrasound attenuation (BUA) and 13.7% lower stiffness index (SI) compared to non-users. No significant association was observed between anticonvulsant use in women and spinal BMD, SOS, BUA or SI but BMD tended to be 5.8% lower at the hip compared to non-users. Conclusion: Our data suggest that bone quantity and quality, assessed using BMD and QUS, are lower for men and possibly women who use anticonvulsants. While further exploration into potential mechanisms is needed, our findings suggest that monitoring bone health among users of anticonvulsants is warranted.

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Quantitative ultrasound and bone health

Cited by 19 publications

References 107 publications

<p>The Relation Between Calcaneus Stiffness Index as a Measure of Bone Density and Body Mass Index in an Egyptian Cohort</p>

<p>The Relation Between Calcaneus Stiffness Index as a Measure of Bone Density and Body Mass Index in an Egyptian Cohort</p>

Clinical utilities of quantitative ultrasound in osteoporosis associated with inflammatory rheumatic diseases

Anticonvulsant Use and Bone Health in a Population-based Study of Men and Women: Cross-sectional Data from the Geelong Osteoporosis Study.

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