Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

Sekar, Sanathana Konugolu Venkata; Lanka, Pranav; Farina, Andrea; Mora, Alberto Dalla; Andersson‐Engels, Stefan; Taroni, Paola; Pifferi, Antonio

doi:10.3390/app9245465

Cited by 18 publications

(20 citation statements)

References 179 publications

(277 reference statements)

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“…Diagnostic or monitoring tools that rely on the optical characteristics of the treated tissue are potentially good candidates in this direction. Optical techniques employing parameters such as diffuse reflectance and transmittance 14 – 16 , fluorescence 14 , absorbance using visible light spectroscopy 17 and optical properties 18 – 24 (absorption and scattering coefficient), have obtained interesting initial results in studying the effect of thermal treatment on biological tissue 25 . Many distinct transformations occur during RFA treatment, involving both microstructure alterations leading to scattering changes, and modification in different tissue constituents (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…This capacity to decouple the two optical properties can be of great value to separate distinct thermal effects, leading to identification of specific markers to grade tissue transformation during RFA treatment. Further, the approach is unaffected by factors like signal fluctuations, skin pigmentation, optical contact with the sample, surface roughness and irregularities 25 , since it relies only on the temporal shape of the DTOF and not on its amplitude. Thus, we expect negligible artefacts due to bleeding, charring at the fiber tip or bubble formation often related to RFA treatment 28 .…”

Section: Introductionmentioning

confidence: 99%

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Optical signatures of radiofrequency ablation in biological tissues

Lanka

Francis

Kruit

et al. 2021

Sci Rep

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Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse optical spectroscopy was used, which enabled us to disentangle and quantify absorption and reduced scattering spectra. In addition to the well-known global (1) decrease in absorption, and (2) increase in reduced scattering, we uncovered new features based on sensitive detection of spectral changes. These absorption spectrum features are: (3) emergence of a peak around 840 nm, (4) redshift of the 760 nm deoxyhemoglobin peak, and (5) blueshift of the 970 nm water peak. Treatment temperatures above 100 °C led to (6) increased absorption at shorter wavelengths, and (7) further decrease in reduced scattering. This optical behavior provides new insights into tissue response to thermal treatment and sets the stage for optical monitoring of radiofrequency ablation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optical signatures of radiofrequency ablation in biological tissues

Lanka

Francis

Kruit

et al. 2021

Sci Rep

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“…From these DTOF, various data processing methods can be employed to extract information about the tissue. It is out of the scope of this paper to detail these methods, but the interested reader can refer to the following reviews for a more in-depth description of TD-NIRS methodologies [9,10], and for a special focus on broadband TD-NIRS [11], which will be largely discussed in the present work.…”

Section: Introductionmentioning

confidence: 99%

The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging

2021

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Optical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implementation of these technique were hindered by technological limitations, mainly from the light sources and/or detection electronics. In the past 20 years, the developments of supercontinuum laser (SCL) enabled to unlock some of these limitations, enabling the development of system and methodologies relevant for medical use, notably in terms of spectral monitoring. In this review, we focus on the use of SCL in biomedical diffuse optics, from instrumentation and methods developments to their use for medical applications. A total of 95 publications were identified, from 1993 to 2021. We discuss the advantages of the SCL to cover a large spectral bandwidth with a high spectral power and fast switching against the disadvantages of cost, bulkiness, and long warm up times. Finally, we summarize the utility of using such light sources in the development and application of diffuse optics in biomedical sciences and clinical applications.

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“…Optical methods like Diffuse Optical Spectroscopy (DOS) have been used to non-invasively investigate various organs of the human body, like the breast, forehead, and bone 1,2 . More recent works have also successfully demonstrated the use of this technique in monitoring the effects of diet control on abdominal fat tissue 3,4 and of exercise-related mechanisms on the skeletal muscles 5,6 .…”

Section: Introductionmentioning

confidence: 99%