Optical signatures of radiofrequency ablation in biological tissues

Lanka, Pranav; Francis, Kalloor Joseph; Kruit, Hindrik; Farina, Andrea; Cubeddu, Rinaldo; Sekar, Sanathana Konugolu Venkata; Manohar, Srirang; Pifferi, Antonio

doi:10.1038/s41598-021-85653-0

Cited by 18 publications

(21 citation statements)

References 51 publications

(17 reference statements)

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“…Tine visualization was not superior with PA imaging, being comparable with the US in chicken tissue, but of lower magnitude in liver tissue with PA imaging. Due to differing optical properties, the tines could be distinguished at a greater distance from the AFP in the PA image in chicken tissue (~9 mm) than in liver tissue (~4 mm) [ 40 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…For accurate assessment of ablation, targeting the ablation boundary should be accompanied by distinguishing native from ablated tissue. Therefore, in future work, we will explore multi-wavelength PA imaging for visualizing the differences in optical properties between native and ablated tissue [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…The determined values of

and

of native and ablated liver tissue at 70 °C were taken from reference [ 40 ], from which

was evaluated as

[ 42 ]. Generally, in ablated liver tissue, the absorption is lower, while the scattering is considerably higher compared to the native state.…”

Section: Methodsmentioning

confidence: 99%

“…Two experiments were performed, both having a

of 10 cm −1 , approximately the value for native liver tissue around 680 nm, see [ 40 ]. In many experiments, chicken tissue was used to mimic tissue surrounding the liver.…”

Section: Methodsmentioning

confidence: 99%

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Annular Fiber Probe for Interstitial Illumination in Photoacoustic Guidance of Radiofrequency Ablation

Kruit

Francis

Rascevska

et al. 2021

Sensors

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Unresectable liver tumors are commonly treated with percutaneous radiofrequency ablation (RFA). However, this technique is associated with high recurrence rates due to incomplete tumor ablation. Accurate image guidance of the RFA procedure contributes to successful ablation, but currently used imaging modalities have shortcomings in device guidance and treatment monitoring. We explore the potential of using photoacoustic (PA) imaging combined with conventional ultrasound (US) imaging for real-time RFA guidance. To overcome the low penetration depth of light in tissue, we have developed an annular fiber probe (AFP), which can be inserted into tissue enabling interstitial illumination of tissue. The AFP is a cannula with 72 optical fibers that allows an RFA device to slide through its lumen, thereby enabling PA imaging for RFA device guidance and ablation monitoring. We show that the PA signal from interstitial illumination is not affected by absorber-to-surface depth compared to extracorporeal illumination. We also demonstrate successful imaging of the RFA electrodes, a blood vessel mimic, a tumor-mimicking phantom, and ablated liver tissue boundaries in ex vivo chicken and bovine liver samples. PA-assisted needle guidance revealed clear needle tip visualization, a notable improvement to current US needle guidance. Our probe shows potential for RFA device guidance and ablation detection, which potentially aids in real-time monitoring.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The determined values of

and

of native and ablated liver tissue at 70 °C were taken from reference [ 40 ], from which

was evaluated as

[ 42 ]. Generally, in ablated liver tissue, the absorption is lower, while the scattering is considerably higher compared to the native state.…”

Section: Methodsmentioning

confidence: 99%

“…Two experiments were performed, both having a

of 10 cm −1 , approximately the value for native liver tissue around 680 nm, see [ 40 ]. In many experiments, chicken tissue was used to mimic tissue surrounding the liver.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Annular Fiber Probe for Interstitial Illumination in Photoacoustic Guidance of Radiofrequency Ablation

Kruit

Francis

Rascevska

et al. 2021

Sensors

Self Cite

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show abstract

“…Since the optical properties of tissues, such as absorption and scattering, can be affected by their temperature, one can measure the tissue temperature by measuring the change in these properties [ 182 , 183 , 184 , 185 ]. In this regard, Raman spectroscopy presents the advantage of enabling temperature measurements with high chemical specificity; however, in its basic form, it is limited to near surfaces within diffusely scattering samples.…”

Section: Temperature Monitoring During Pttmentioning

confidence: 99%

Nanoparticle-Mediated Photothermal Therapy Limitation in Clinical Applications Regarding Pain Management

et al. 2022

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The development of new effective cancer treatment methods has attracted much attention, mainly due to the limited efficacy and considerable side effects of currently used cancer treatment methods such as radiation therapy and chemotherapy. Photothermal therapy based on the use of plasmonically resonant metallic nanoparticles has emerged as a promising technique to eradicate cancer cells selectively. In this method, plasmonic nanoparticles are first preferentially uptaken by a tumor and then selectively heated by exposure to laser radiation with a specific plasmonic resonant wavelength, to destroy the tumor whilst minimizing damage to adjacent normal tissue. However, several parameters can limit the effectiveness of photothermal therapy, resulting in insufficient heating and potentially leading to cancer recurrence. One of these parameters is the patient’s pain sensation during the treatment, if this is performed without use of anesthetic. Pain can restrict the level of applicable laser radiation, cause an interruption to the treatment course and, as such, affect its efficacy, as well as leading to a negative patient experience and consequential general population hesitancy to this type of therapy. Since having a comfortable and painless procedure is one of the important treatment goals in the clinic, along with its high effectiveness, and due to the relatively low number of studies devoted to this specific topic, we have compiled this review. Moreover, non-invasive and painless methods for temperature measurement during photothermal therapy (PTT), such as Raman spectroscopy and nanothermometry, will be discussed in the following. Here, we firstly outline the physical phenomena underlying the photothermal therapy, and then discuss studies devoted to photothermal cancer treatment concerning pain management and pathways for improved efficiency of photothermal therapy whilst minimizing pain experienced by the patient.

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