Brinzolamide–loaded nanoemulsions: <i>ex vivo</i> transcorneal permeation, cell viability and ocular irritation tests

Mahboobian, Mohammad Mehdi; Seyfoddin, Ali; Aboofazeli, Reza; Foroutan, Seyed Mohsen; Rupenthal, Ilva D.

doi:10.1080/10837450.2018.1547748

Cited by 44 publications

(21 citation statements)

References 28 publications

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“…of treatment. cTA-NLC also shows a similar kind of results with no signs of irritation[41]. The results are in agreement with the cell viability studies, which confirm the non-irritant and biocompatible nature of cTA-NLC.…”

supporting

confidence: 88%

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Triamcinolone acetonide loaded-cationic nano-lipoidal formulation for uveitis: Evidences of improved biopharmaceutical performance and anti-inflammatory activity

Nirbhavane

Sharma

Singh

et al. 2020

Colloids and Surfaces B: Biointerfaces

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Link to publication on Research at Birmingham portal General rightsUnless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposes permitted by law.• Users may freely distribute the URL that is used to identify this publication.• Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research.• User may use extracts from the document in line with the concept of 'fair dealing' under the Copyright, Designs and Patents Act 1988 (?) • Users may not further distribute the material nor use it for the purposes of commercial gain.Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document.When citing, please reference the published version. Take down policyWhile the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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supporting

confidence: 88%

“…The sum scores for all three irritant responses were made to yield a single numerical value. The scoring of the irritant responses was done as a) < 0.9 =Non-irritant b) 1-4.9 as slight irritant, 5-8.9 moderately irritant, 9-21-severe irritant [40,41].…”

Section: Ocular Irritancy Testmentioning

confidence: 99%

Triamcinolone acetonide loaded-cationic nano-lipoidal formulation for uveitis: Evidences of improved biopharmaceutical performance and anti-inflammatory activity

Nirbhavane

Sharma

Singh

et al. 2020

Colloids and Surfaces B: Biointerfaces

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“…The ex vivo permeation data suggest that there is more than 40-50% permeation achieved with LB-NPloaded contact lenses as compared to marketed eye drops due to the presence of POLTF. This increase in the permeation through nanoparticle-loaded contact lenses across the cornea is due to the presence of POLTF from which the medication is administered gradually into the precorneal region [36].…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, LB solution-loaded contact lenses were also used to study transcorneal permeation through goat cornea to achieve comparative results. The permeation was studied for 6 h, and all the experiments were undertaken in triplicate [35,36]. Percentage transcorneal permeation has been measured as:…”

Section: Ex Vivo Transcorneal Permeation Studymentioning

confidence: 99%

Extended levobunolol release from Eudragit nanoparticle-laden contact lenses for glaucoma therapy

2020

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Background Majorly, the reason for the permanent loss of vision is glaucoma. But the currently available common treatment methodologies such as eye drops have various disadvantages like patient incompliance due to repeated administration and poor (1–5%) bioavailability leading to poor efficiency. The objective of this research was to formulate Eudragit-based nanoparticles of levobunolol incorporated into a contact lens to obtain sustained ocular delivery of levobunolol at the therapeutics level. Eudragit nanoparticles of levobunolol were formulated by nanoprecipitation methodology utilizing different ratios of Eudragit S100 and polyvinyl alcohol. The prepared nanoparticles were evaluated and optimized by efficiency of entrapment, particle size, morphology of surface and zeta potential. The optimized nanoparticles were then entrapped into the matrix of the contact lens by the soaking method which were then characterized and compared for optical clarity study, equilibrium swelling study, shelf life and in vitro drug release in simulated tear fluid followed by ex vivo transcorneal permeation study. Results Formulation F3 was obtained as optimized nanoparticle formulation with 102.61 nm ± 3.92 of particle size, − 22.2 mV ± 2.76 of zeta potential and 86.995% ± 1.902 of efficiency of entrapment. The equilibrium swelling index and transmittance of nanoparticle incorporated into contact lenses showed better results when compared to drug solution-loaded lenses. In vitro release indicated more sustained drug profiles (84.33% ± 0.34 of drug release over a period of 12 days) as compared to drug solution-loaded lenses (89.282% ± 0.900 of drug release over a period of 3 days). Ex vivo transcorneal permeation studies showed more permeation (6.75% ± 0.170) through contact lenses as compared to marketed eye drops (3.03% ± 0.088). Conclusion This research demonstrates the remarkable results of drug-laden contact lenses to serve as a great medium for the continued delivery of ocular drugs without affecting the physical and optical characteristics of the lens content.

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“…The optimized nanoemulsion formulation showed high corneal penetration by 2 to 3-fold higher when compared to the marketed ocular suspension (Azopt). The ex vivo and in vivo studies revealed that the prepared formulation was safe and had a high penetrating effect as compared to Azopt [ 66 ].…”

Section: Need For Nanomedicine For Ocular Drug Deliverymentioning

confidence: 99%

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

Qamar

Qizilbash

Iqubal

et al. 2020

DDF

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The structure of the eye is very complex in nature which makes it a challenging task for pharmaceutical researchers to deliver the drug at the desired sites via different routes of administration. The development of the nano-based system helped in delivering the drug in the desired concentration. Improvement in penetration property, bioavailability, and residence time has all been achieved by encapsulating drugs into liposomes, dendrimers, solid lipid nanoparticle, nanostructured lipid carrier, nanoemulsion, and nanosuspension. This review puts emphasis on the need for nanomedicine for ocular drug delivery and recent developments in the field of nanomedicine along with recent patents published in the past few years.

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Brinzolamide–loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests

Cited by 44 publications

References 28 publications

Triamcinolone acetonide loaded-cationic nano-lipoidal formulation for uveitis: Evidences of improved biopharmaceutical performance and anti-inflammatory activity

Triamcinolone acetonide loaded-cationic nano-lipoidal formulation for uveitis: Evidences of improved biopharmaceutical performance and anti-inflammatory activity

Extended levobunolol release from Eudragit nanoparticle-laden contact lenses for glaucoma therapy

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

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