Brief report: Effects of fenfluramine on behavioral, cognitive, and affective disturbances in autistic children

August, Gerald J.; Raz, Naftali; Baird, Teresa D.

doi:10.1007/bf01837901

Cited by 50 publications

(22 citation statements)

References 6 publications

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“…This reduction was accompanied by a significant decrease in motor activity. The results of biochemical and behavioral analysis are reported in August et al [1985]. Changes in EEG param eters and BTT are presented in table I.…”

Section: Resultsmentioning

confidence: 99%

“…Since then, a collaborative multicenter project involving a considerable number of patients in several medical centers across the country has yielded results suggesting that fenfluramine therapy might bring some symptomatic improvement to about 85% of autis tic patients [Ritvo et al. 1986], It has been suggested that amelioration of excessive locomotion, distractibility, and poor attention may be fenfluramine's most consistent therapeutic effect in au tistic children [August et al, 1985]. If fenfluramine indeed works in autism as a major tranquilizer, one would expect to see a reflection of this property in its EEG 'signature'.…”

mentioning

confidence: 99%

“…The classification of fenfluramine based on acute administration in adults appears to be at odds with behavioral effects of fenfluramine observed in autistic children [August et al, 1985]. It is therefore important to determine the pattern of changes produced by fenflu ramine in the EEG profiles of autistic children.…”

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confidence: 99%

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Effects of Fenfluramine on EEG and Brainstem Average Evoked Response in Infantile Autism

1987

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The effects of fenfluramine on electrophysiological activity in autistic children were assessed by computerized EEG power analysis and brainstem evoked responses (BSER). Prolonged administration of fenfluramine resulted in a decrease of relative share of α-waves in the EEG power spectrum and in corresponding increase in slow activity. No effects of the drug on BSER latencies were observed. The spectral EEG pattern of fenfluramine identified in this sample was compared to the spectra reported for normal volunteers on an acute dose of fenfluramine. The implications of these findings for EEG classification of fenfluramine and neurochemical mechanisms of autism are discussed.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Effects of Fenfluramine on EEG and Brainstem Average Evoked Response in Infantile Autism

1987

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“…However, these preliminary observations were not fully supported in two more recent studies by August et al 5 and Ho et alt > The development of an Correspondence: N R Badcoek. accurate and reliable method for measuring serotonin in the blood will thus be of importance in any research work associated with infantile autism, mental retardation and other childhood psychoses.…”

mentioning

confidence: 83%

Blood Serotonin Levels in Adults, Autistic and Non-Autistic Children—With a Comparison of Different Methodologies

Badcock

Spence

Stern³

1987

Ann Clin Biochem

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SUMMARY.Recent interest in conditions associated with increased blood serotonin level has highlighted the need for consistency between assay methods to allow for more accurate delineation of serotinin variables. To this end, comparison was made between a spectrofluorimetric technique frequently used in the past and two potentially more specific high performance liquid chromatographic procedures. Normal ranges and diurnal variations for blood serotonin in adults, normal, autistic children and children with developmental dysphasia were also determined. No significant difference was found between serotonin level in blood drawn by simultaneous venepuncture and capillary (fingerprick) collection. Whilst there was no evidence of circadian rhythm, seasonal variation with mean blood serotonin levels significantly lower in summer than in two successive winters was suggested. Blood serotonin values in normal children tended to decline with increasing age. No similar maturational effect was apparent in autistic children. The mean level for autistic children in winter was significantly higher than that for normal children in the same 'Season; despite this there was considerable overlap of blood serotonin levels between normal and autistic groups. Serotonin levels determined by the three different methodologies showed a high correlation but differed significantly: caution should be exercised when comparing blood serotonin results where different methods are employed.

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“…Fenfluramine has been evaluated as a possible treatment for the autistic syndrome in part PART IV • PREVENTION AND TREATMENT because of the finding that 30 to 40% of autistic patients have elevated blood serotonin levels (see Table 2H) (August, Raz, & Baird, 1985;Campbell, 1988;Ritvo et aI., 1986). Fenfluramine is a sympathomimetic amine related to the amphetamines and is utilized in adults as an appetite suppressant.…”

Section: Fenfluraminementioning

confidence: 99%

Child and Adolescent Psychopharmacology

Wilens

Spencer

Frazier

et al. 1998

Handbook of Child Psychopathology

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Brief report: Effects of fenfluramine on behavioral, cognitive, and affective disturbances in autistic children

Cited by 50 publications

References 6 publications

Effects of Fenfluramine on EEG and Brainstem Average Evoked Response in Infantile Autism

Effects of Fenfluramine on EEG and Brainstem Average Evoked Response in Infantile Autism

Blood Serotonin Levels in Adults, Autistic and Non-Autistic Children—With a Comparison of Different Methodologies

Child and Adolescent Psychopharmacology

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