Child and Adolescent Psychopharmacology

Wilens, Timothy E.; Spencer, Thomas; Frazier, Jean A.; Biederman, Joseph

doi:10.1007/978-1-4615-5905-4_25

Cited by 3 publications

(3 citation statements)

References 133 publications

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“…In general, the changes in cardiovas- cular parameters observed here are similar in magnitude to those reported previously with MAS XR among pediatric patients with ADHD. 23 In one previous investigation, adolescents treated with openlabel once-daily MAS XR (10-60 mg/day) for up to 6 months exhibited small, clinically insignificant mean increases at end point in baseline SBP (1.7 mm Hg), DBP (0.6 mm Hg), and pulse (4.4 bpm). Similarly, the current findings are in line with a recent report describing changes in heart rate and BP observed in a number of small, short-term clinical trials of stimulant and nonstimulant medications in adults with ADHD.…”

Section: Discussionmentioning

confidence: 89%

Long-Term Cardiovascular Effects of Mixed Amphetamine Salts Extended Release in Adults With ADHD

Weisler¹,

Biederman²,

Spencer³

et al. 2005

CNS Spectr.

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Objective: To assess long-term cardiovascular effects of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) combined subtype.Methods: 223 otherwise healthy adults (≥18 years of age) with ADHD combined subtype were exposed to ≤24 months of MAS XR (20–60 mg/day). Resting sitting diastolic blood pressure (DBP) and systolic blood pressur (SBP) and pulse were measured at baseline and weekly, then monthly during long-term treatment. Twelve-lead electrocardiograms were obtained at screening/baseline, weekly, then at 3-and 6-month intervals up to 24 months.Findings: With MAS XR 20–60 mg/day, mean changes in DBP (1.3±9.2 mm Hg; P=.O42), SBP (2.3±12.5 mmHg; P=.OO6), and pulse (2.1±13.4 bpm; P=.019) were small and not clinically significant. A clinically insignificant increase in QTcB (corrected by Bazett's formula) interval (7.2 msec; P<.001) was observed at 24 months. No subject exhibited QTcB interval >480 msec (QTcF [corrected by Fridericia's formula] >454 msec). Seven subjects discontinued due to a car-diovascular adverse event (hypertension, n=5, palpitation/tachycardia, n=2); none of these events was reported as serious. Few subjects with normal baseline vital signs (using approved parameters at the time of study initiation) exhibited clinically significant abnormalities at end point; several subjects with borderline baseline values exhibited shifts to abnormal values during MAS XR therapy.Conclusion: Cardiovascular effects of long-term MAS XR (≤60 mg/day) were minimal in otherwise healthy adults with ADHD. Nevertheless, vital signs should be monitored prior to and during treatment with any stimulant.

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Section: Discussionmentioning

confidence: 89%

Long-Term Cardiovascular Effects of Mixed Amphetamine Salts Extended Release in Adults With ADHD

Weisler¹,

Biederman²,

Spencer³

et al. 2005

CNS Spectr.

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“…These factors include symptoms, such as aggressive or assaultive behavior (Ahsanuddin et al 1983;Schur et al 2003), selfabuse or self-injury (Wilens et al 1998), suicidality (Dean et al 2006), disability (dosReis et al 2005, and severity of illness (Duffy et al 2005), as well as psychosocial risk factors such as living away from home (Connor et al 1998;Zima et al 1999;Raghavan et al 2005).…”

Section: Correlates Of Medication Initiation and Changementioning

confidence: 99%

Initiation and Change of Psychotropic Medication Regimens among Adolescents in Inpatient Care

Warner

Fontanella

Pottick

2007

Journal of Child and Adolescent Psychopharmacology

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“…Findings from available controlled trials using samples of anxious children/adolescents indicate that drug classes such as benzodiazepines and selective serotonin reuptake inhibitors (SSRIs) may be efficacious (Velosa & Riddle, 2000;Wilens, Spencer, Frazier & Biederman, 1998). However, most studies have not examined pharmacotherapy among samples of children with childhood social phobia only.…”

Section: Treatmentmentioning

confidence: 99%

Does negative self-imagery play a causal role in social phobia among adolescents?

Alfano¹

2004

PsycEXTRA Dataset

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The current study was designed to examine whether negative self-imagery is a significant factor in the development of social phobia among adolescents. Although some adult models of social phobia posit that negative self-imagery serves to increase anxiety and decrease performance within social contexts, few studies have directly examined this relationship and no study has examined self-imagery among sociallyphobic adolescents. For the current study, negative self-imagery was manipulated among a group of non-anxious adolescents (IMAG) during two social tasks. Levels of anxiety, specific thoughts, expected and self-rated performance, and observer-rated performance and social skill were compared to both socially-phobic and control adolescents. Results revealed few differences in terms of observer-rated performance and specific social skill between the IMAG and control groups of adolescents, although the socially-phobic group was consistently rated to exhibit poorer performances and decreased social skill. The IMAG group reported marginally significant increases in their anxiety levels during both social tasks. Interestingly, these adolescents reported similar (increased) rates of anxiety during an additional social interaction task where they were instructed to use positive self-imagery. The IMAG group also reported decreases in performance compared to the control group. This finding appears to be explained primarily based on the adolescents' belief that they were unable to hide their anxiety rather than a decrease in social skill (such as reported by socially-phobic youth). Further, the IMAG group reported an overall fewer number of cognitions than both groups during the social interaction task, potentially indicating a significant decrease in cognitive resources based on the use of self-imagery. Overall findings from this investigation do not support the hypothesis that negative self-imagery plays a causal role in the development of social phobia among adolescents. Rather, results indicate that an excessive self-focus within social contexts, together with normal developmental increases in self-consciousness during the adolescent years, may pose a specific risk for development of the syndrome. These findings provide a developmental understanding of the factors involved in the onset of social phobia, as well as those symptoms that may be germane to the maintenance of the disorder over time.

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Child and Adolescent Psychopharmacology

Cited by 3 publications

References 133 publications

Long-Term Cardiovascular Effects of Mixed Amphetamine Salts Extended Release in Adults With ADHD

Long-Term Cardiovascular Effects of Mixed Amphetamine Salts Extended Release in Adults With ADHD

Initiation and Change of Psychotropic Medication Regimens among Adolescents in Inpatient Care

Does negative self-imagery play a causal role in social phobia among adolescents?

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