Brief Report

Mirsal, Hasan; Yalug, Irem; Tan, Devran; Stern, Theodore A.; Kalyoncu, Ayhan; Pektaş, Özkan; Erdogan, Gamze; Beyazyürek, Mansur

doi:10.4088/pcc.v07n0505

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Furthermore, some mutations in ALDH isozymes have been described that lead to specific clinical phenotypes or diseases, and many of these diseases are characterized by neurologic abnormalities [ 5 ]. Disulfiram (Antabuse, TT), an ALDH inhibitor used to treat alcoholism, has been reported to cause significant neurologic toxicity in patients [ 43 , 44 ]. Thus, it is not surprising to detect such wide spread changes in the levels of multiple genes as revealed in our microarray analysis.…”

Section: Discussionmentioning

confidence: 99%

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

et al. 2008

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Section: Discussionmentioning

confidence: 99%

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

et al. 2008

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“…Most of the previous studies suggest that delirium is associated with the disulfiram-ethanol reaction. 61,62 However, both the case reports in the present review reported onset of delirium like reaction without alcohol challenge.…”

Section: Discussionmentioning

confidence: 60%

Adverse Drug Reactions to Disulfiram Treatment with or without Alcohol Challenge in the Indian Setting: Systematic Review

Basu¹,

Joseph²

2018

Journal of Postgraduate Medicine, Education and Research

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Background: Disulfiram has been used for treating alcohol dependence in the Indian population for the last three decades. The safety concerns associated with adverse effectsraise a high index of suspicion for disulfiram therapy in Indian population. Surprisingly few reviews exist on adverse reaction to disulfiram treatment and most of such articles published during the 1990s. Moreover, such systematic investigation relevant to the Indian population is missing in the literature. Thepresent review aims to narrate and discuss disulfiram induced adverse reactionsin the Indian setting. Materials and methods:We analyzed clinical trials, observational studies and case reports of adverse drug reactions to disulfiram therapy reportedin the Indian setting. Relevant studies published within 2017 in the electronic databases: Medline, IndMED, Ermed, and Embase were included. The Naranjo adverse drug reaction probability scale (NADRPS) was used for assessing adverse drug reactions to disulfiram treatment. Results:The present review identified four open-label trials, four observational studies and 24 case reports describing thirtytwo cases of disulfiram-induced adverse reactions in the Indian setting. Psychiatric adverse events and de novo convulsions were the common adverse reactions to disulfiram treatment without alcohol challenge in this setting. The NADRPS score was found to be from 5-9 and the magnitude of the adverse effects associated with disulfiram-ethanol reaction was largely associated with surreptitious use. Conclusion:The review is a pioneer attempt for an evidence base summary of common adverse reactions and temporal association of dose-dependent adverse effects to disulfiram treatment in the Indian setting. The results of the review open an area of discussion regarding ethnic variations and the adverse effects of disulfiram in clients treated for alcohol dependence in this setting.

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“…Studies in the literature reported delirium induced by disulfiram-ethanol interaction and encephalopathy manifestations induced by disulfiram (24,25). Since our patient had not drunk alcohol while he was taking disulfiram, the possibility of disulfiram-alcohol interaction was eliminated.…”

Section: Discussionmentioning

confidence: 69%

Disülfirama bağlı olarak gelişen bir katatoni olgusu

Balaban¹,

Atagün²,

Alpkan³

2010

Dusunen Adam

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Disülfirama bağlı olarak gelişen bir katatoni olgusu Katatoni, sınıflandırma sistemlerinde daha çok şizofreninin bir alt grubu olarak değerlendirilmiş olsa da, birçok genel tıbbi durum, nörolojik hastalık ya da bazı ilaçlara bağlı olarak da ortaya çıkabilir. Disülfiram, alkol bağımlılığı tedavisinde caydırıcı etkisi nedeniyle kullanılabilen bir ajandır. Psikoz ve deliryum gibi nöropsikiyatrik yan etkilere neden olabilir. Katatonik sendrom disülfiramın çok nadir görülen bir yan etkisidir. Bu yazıda, kliniği bilişsel işlevlerde bozulma ile başlayan ve katatonik sendroma dönüşen bir vaka sunulmaktadır. Hastanın alkol kötüye kullanımı dışında psikiyatrik öyküsü yoktu ve son 1 aydır, reçetesiz temin ettiği disülfiramı kullanıyordu. Hastaya, disülfirama bağlı katatoni tanısı ile elektrokonvülsif tedavi uygulandı. Tam düzelme sağlanan ve ilaçsız izlenen vakanın iyilik hali devam etti. Bu çalışmada, örnek vaka çerçevesinde katatoni kavramı tartışılmaktadır.

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Brief Report

Cited by 7 publications

References 27 publications

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

Adverse Drug Reactions to Disulfiram Treatment with or without Alcohol Challenge in the Indian Setting: Systematic Review

Disülfirama bağlı olarak gelişen bir katatoni olgusu

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