Brief but enough: 45-min maternal separation elicits behavioral and physiological responses in neonatal mice and changes in dam maternal behavior

Burenkova, Olga; Averkina, A.A.; Aleksandrova, E. A.; Zarayskaya, Irina Yu.

doi:10.1016/j.physbeh.2020.112877

Cited by 8 publications

(10 citation statements)

References 60 publications

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“…Interestingly, in this study, maternal care was assessed prior to separation (Der‐Avakian & Markou, 2010). Other groups did not find changes in maternal care showing that separated and nonseparated had similar frequencies of arched‐back nursing, licking and grooming, and nest‐building behavior after LMS (Orso et al., 2018; Romeo et al., 2003; Tan et al., 2017) and BMS (Anisman et al., 1998; Burenkova et al., 2020; D'Amato et al., 1998; Macrì et al., 2008; Pryce et al., 2001; Wei et al., 2010). However, recent studies report increased arched‐back nursing after LMS along with no changes in pup retrieval time and less time spent on self‐grooming in SD rat dams (Bölükbas et al., 2020; Noori et al., 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Other groups followed MS procedures in which rat pups were crossfostered into all male or all female litters (Kalinichev et al, 2000). With evidence showing that Long-Evans dams licked their male infants more Liu et al, 1997;Macrì et al, 2004Macrì et al, , 2008Stamatakis et al, 2015Burenkova et al, 2020; Own & Patel, 2013;Wei et al, 2010Boccia et al, 2007Bölükbas et al, 2020;de Sá Couto-Pereira et al, 2016;Macrì et al, 2004Macrì et al, , 2008Zimmerberg & Sageser, 2011;Zimmerberg et al, 2003Own & Patel, 2013Atkinson et al, 2000Field, 2010;Kim et al, 2014;Lovejoy & Graczyk, 2000 Note: Increased, decreased, and unaltered maternal care outcomes were obtained from data in rodents (mice and rats) after brief and long maternal separation (BMS and LMS) from pups. Comparisons with human findings of women suffering from postpartum depression demonstrate the similarities that occur in dams after BMS and LMS with affected women.…”

Section: Maternal Carementioning

confidence: 99%

“…The same holds for postnatal days investigated. In the case of some studies, for example, for Burenkova et al (2020), dependent on the postnatal day being investigated, certain behaviors were increased while others were unchanged and this pattern changed between days (Burenkova et al, 2020).…”

Section: Maternal Carementioning

confidence: 99%

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Maternal separation: Does it hold the potential to model consequences of postpartum depression?

Mundorf

Bölükbas

Freund

2022

Developmental Psychobiology

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The postpartum period is a sensitive time where women are especially vulnerable to develop postpartum depression (PPD), with 10%-15% of women affected. This review investigates whether the maternal separation (MS) paradigm in rodents holds the potential to help to understand mothers suffering from PPD. MS is a well-established stress model to investigate effects on infants, whereas effects on the dam are often overlooked. The database PubMed was searched for studies investigating effects of daily MS within the first weeks after parturition on dams in rats and mice and compared to findings in PPD mothers. MS was categorized as brief MS (5-45 min) with or without handling of pups and long MS (3-4 h and longer). MS alters maternal care, depressive-like behavior, anxiety, and aggression; leads to alterations in neuronal gene expression; and affects hormone and neurotransmitter levels similar to observations in PPD patients. Even though there are disparities between human and rodent mothers, with some results differing in directionality, as well as the reason for separation (selfinduced in PPD, externally induced in MS), the overall effects found on neurobiological, hormonal, and behavioral levels mostly coincide. Thus, the MS paradigm can add relevant knowledge to existing PPD animal models, further advancing the study of PPD.

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Section: Resultsmentioning

confidence: 99%

Section: Maternal Carementioning

confidence: 99%

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Maternal separation: Does it hold the potential to model consequences of postpartum depression?

Mundorf

Bölükbas

Freund

2022

Developmental Psychobiology

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“…Because the mother–pup relationship is dynamic and reciprocal, it is expected that MS would affect both members of the dyad (Alves et al, 2019). Recently, it has been shown that MS affects dam's maternal behavior (Aguggia et al, 2019; Alves et al, 2019; Burenkova et al, 2020) and induces anxiety‐ and depressive‐like behaviors in the dams. However, in the case of anxiety, there is contradictory with the results of the previous studies for the impact of MS on mothers' anxiety (Alves et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Zarayskaya, 2020) and induces anxiety-and depressive-like behaviors in the dams. However, in the case of anxiety, there is contradictory with the results of the previous studies for the impact of MS on mothers' anxiety(Alves et al, 2019).…”

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confidence: 99%

Maternal separation impairs mother's cognition 1 month beyond the separation

Joushi

Sheibani

Esmaeilpour

et al. 2021

Intl J of Devlp Neuroscience

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Background: Separation of pups from their dam during the infancy not only has detrimental effects on the pups' brain but also affects dams' behavior. Postpartum stress may affect mothers' cognitive functions. In the present study, by using a 180 min/day maternal separation (MS) paradigm, we assessed anxiety-like behavior (in the elevated plus maze) and locomotor activity (in the open eld) of rat dams which experienced separation from postnatal day (PND) 1 until weaning. Since no study has ever investigated MS effects on spatial learning and memory of dams in the Morris water maze, we tried for the rst time to clarify whether such separation impairs dam's performance in the Morris water maze.Methods:We assessed dams' behavior at three time points; 24 hours, 1 week and 1 month after weaning.Therefore, the six groups consisted of control (CTRL); 24h, 1week and 1month and MS; 24h, 1week and 1month was allocated in this study.Results: Our results revealed that although MS-24h and MS-1week groups had intact locomotor activity, MS-1month group showed less locomotor activity in the open eld. Moreover, MS induced anxiety-like behavior was more pronounced in MS-1week and MS-1month dams. Spatial learning and memory was also impaired only in MS-1month dams.Conclusions: We can conclude that MS induces cognitive impairments in dam that may appear not immediately after the separation, but a few weeks after such stressful event.

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The role of epigenetic mechanisms in the long‐term effects of early‐life adversity and mother–infant relationship on physiology and behavior of offspring in laboratory rats and mice

Burenkova,

Grigorenko

2024

Developmental Psychobiology

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Maternal care during the early postnatal period of altricial mammals is a key factor in the survival and adaptation of offspring to environmental conditions. Natural variations in maternal care and experimental manipulations with maternal–child relationships modeling early‐life adversity (ELA) in laboratory rats and mice have a strong long‐term influence on the physiology and behavior of offspring in rats and mice. This literature review is devoted to the latest research on the role of epigenetic mechanisms in these effects of ELA and mother–infant relationship, with a focus on the regulation of hypothalamic–pituitary–adrenal axis and brain‐derived neurotrophic factor. An important part of this review is dedicated to pharmacological interventions and epigenetic editing as tools for studying the causal role of epigenetic mechanisms in the development of physiological and behavioral profiles. A special section of the manuscript will discuss the translational potential of the discussed research.

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Brief but enough: 45-min maternal separation elicits behavioral and physiological responses in neonatal mice and changes in dam maternal behavior

Cited by 8 publications

References 60 publications

Maternal separation: Does it hold the potential to model consequences of postpartum depression?

Maternal separation: Does it hold the potential to model consequences of postpartum depression?

Maternal separation impairs mother's cognition 1 month beyond the separation

The role of epigenetic mechanisms in the long‐term effects of early‐life adversity and mother–infant relationship on physiology and behavior of offspring in laboratory rats and mice

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