Bridging Repair of Large Rotator Cuff Tears Using a Multilayer Decellularized Tendon Slices Graft in a Rabbit Model

Liu, Guoming; Pan, Juan; Zhang, Yi; Ning, Liang-Ju; Luo, Jingcong; Huang, Fuguo; Qin, Tingwu

doi:10.1016/j.arthro.2018.04.019

Cited by 31 publications

(27 citation statements)

References 47 publications

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“… 6 WKS, 3,6 Mos. Ide, J 2009 [ 95 ] Japan Rat/SD (M, 501 ± 40 g) Con 15/15 SS Defect (full thickness) (~3 × 5 mm) 2, 6, 12 WKS 2, 6, 12 WKS Kabuto, Y 2015 [ 96 ] Japan Rat/SD (M, 12WKS) Self-con 15/15 SS Defect (full thickness) 4, 8 WKS 4, 8 WKS Liu, G. M 2018 [ 97 ] China Rabbit/NZW (2.5–3.0 kg) Self-con 36/36 IS Defect (full thickness) (~3 × 5 mm) 2, 4, 8 WKS 2, 4, 8 WKS Qian, S 2019 [ 98 ] China Rabbit/NZW (F, 2.0–2.5 kg, 4 Mos.) Ran 10/10 SS Defect (full thickness) (~1 cm) 8, 12 WKS / Sevivas, N 2018 [ 99 ] Portugal Rat/Wistar Ran 5/5 SS,IS Chronic tear (full thickness) (16 WKS) 16 WKS 16 WKS Smith, M. J 2020 [ 100 ] USA Canine (22 kg, 2–3Years) Con 4/4 SS Acute tear (non-full thickness) (~3–4 mm) 3,6 Mos.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies

Yang

Kang

Zhao

et al. 2022

Bioactive Materials

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Based on the published animal studies, we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation. 74 animal studies were finally included, of which naturally derived biomaterials were applied the most widely (50.0%), rats were the most commonly used animal model (47.0%), and autologous tissue demonstrated the best outcomes in all animal models. The biomechanical properties of naturally derived biomaterials (maximum failure load: WMD 18.68 [95%CI 7.71–29.66]; P = 0.001, and stiffness: WMD 1.30 [95%CI 0.01–2.60]; P = 0.048) was statistically significant in the rabbit model. The rabbit model showed better outcomes even though the injury was severer compared with the rat model.

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Section: Resultsmentioning

confidence: 99%

Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies

Yang

Kang

Zhao

et al. 2022

Bioactive Materials

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“…The tissue engineering approach provides new ideas for solving this problem. Previous studies have confirmed that some bioactive scaffolds, such as decellularized scaffolds,10,11 electrospun scaffolds12,13 and collagen sponges,14,15 promote tendon-bone healing. Among them, the preparation of electrospinning scaffolds is simple and the cost is low.…”

Section: Introductionmentioning

confidence: 87%

<p>A LbL-Assembled Bioactive Coating Modified Nanofibrous Membrane for Rapid Tendon-Bone Healing in ACL Reconstruction</p>

Han

Zhang

Chen

et al. 2019

IJN

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IntroductionIn anterior cruciate ligament (ACL) reconstruction, hamstring tendon autograft is a well-accepted surgical choice as an alternative ACL graft. But the main disadvantage of autograft is its inefficient healing with host bone-tunnel which will leading to surgery failure.MethodsA biomimetic nanofibrous membrane for tendon-bone integration is fabricated in this work, which is composed of polycaprolactone (PCL) electrospinning membrane and chitosan/hyaluronic acid (CS/HA) multilayers film.ResultsBy using layer-by-layer (LbL) self-assembly this functional CS/HA multilayer films are deposited on the surface of PCL nanofiber to enable the local delivery of stromal cell-derived factor-1 α (SDF-1α) and bone morphogenetic protein-2 (BMP-2) in tendon-bone interface. This membrane can promote cell proliferation and recruitment, as well as inducing the osteogenic differentiation and recruitment of BMSCs.ConclusionFurther in vivo studies demonstrate that to wrap the tendon autograft using the membrane may afford superior tendon-bone integration and inhibit scar tissue formation in a rabbit ACL reconstruction model. More importantly, the biomechanical properties of the tendon-bone interface have been improved. This study shows that this biomimetic nanofibrous membrane is effective for improving tendon-bone healing after ACL reconstruction surgery.

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“…A histological evaluation was performed on the scaffold topography, and we evaluated the differences between specimens at two and eight weeks in terms of the cell infiltration, inflammatory response, and collagen arrangement. In the second step, we evaluated the gross morphology of the integration between the DTS and tendon and the inflammatory reaction [ 7 , 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…An alternative by which to achieve better surgical results for massive rotator cuff tears is the use of tissue-engineered tendons, and current research has shown that scaffolds are a reliable alternative that can be used similarly to tissue-engineered tendons [ 6 , 7 ]. An ideal scaffold for tendon disorders and rotator cuff tears should be (a) three-dimensional in structure with high porosity; (b) devoid of cellular material to minimize the inflammatory potential, disease transmission, and host immune response; (c) cytocompatible; and (d) of sufficient biomechanical capacity to withstand rehabilitation until complete remodelling has occurred [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A new decellularized tendon scaffold for rotator cuff tears – evaluation in rabbits

Santos

Silva

Barreto

et al. 2020

BMC Musculoskelet Disord

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Background Scaffolds have considerably advanced in recent years. In orthopaedic surgery, scaffolds have been used as grafts in procedures involving tendon and ligament reconstruction. This paper aimed to produce and evaluate decellularized tendon scaffolds (DTSs) from biomechanical, microscopic, macroscopic and in vivo perspectives. Methods Bilateral gastrocnemius muscle tendons from 18 adult New Zealand rabbits were collected. Of these 36 tendons, 11 were used as controls (Group A - control), and 25 were used in the decellularization protocol (Group B - DTS). The groups were subjected to histological, biomechanical and macroscopic analyses, and Group B - DTS was subjected to an additional in vivo evaluation. In the decellularization protocol, we used a combination of aprotinin, ethylenediamine tetraacetic acid (EDTA), sodium dodecyl sulfate (SDS) and t-octyl-phenoxypolyethoxyethanol (Triton X-100) for six days. During this period, the scaffolds were kept at room temperature on an orbital shaker with constant motion. Results The DTSs showed an increased cross-sectional area and inter-fascicular distance and no change in parallelism or matrix organization. The nuclear material was not organized in the DTSs as it was in the control. In the biomechanical analysis, no significant differences were found between the groups after analysing the ultimate tensile load, stiffness, and elongation at the ultimate tensile load. During the in vivo evaluation, mononuclear cell infiltration was noted. Conclusions The evaluated decellularization protocol generated a tendon scaffold, maintained the most important biomechanical characteristics and permitted cell infiltration.

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Bridging Repair of Large Rotator Cuff Tears Using a Multilayer Decellularized Tendon Slices Graft in a Rabbit Model

Cited by 31 publications

References 47 publications

Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies

Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies

<p>A LbL-Assembled Bioactive Coating Modified Nanofibrous Membrane for Rapid Tendon-Bone Healing in ACL Reconstruction</p>

A new decellularized tendon scaffold for rotator cuff tears – evaluation in rabbits

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