Breeding of Mice Strains for Diabetes Mellitus

Nishimura, Masahiko

doi:10.1538/expanim1957.18.4_147

Cited by 114 publications

(71 citation statements)

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“…KK-Ay mice, which are known for genetically induced diabetes, including ob/ob mice (6) and KK mice (7) , were hyperinsulinemia as a result of insulin resistance (8) . However, TS (1,500 mg/kg) had no effect on the blood glucose levels of STZ-induced diabetic mice , one of the animal models of insulin-dependent diabetes mellitus (IDDM) with hypo insulinemia (9).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic Activity of To-Kai-San (Chinese Medicines) in Normal and KK-Ay Mice.

Miura

Noda

Fukunaga³

et al. 1997

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic Activity of To-Kai-San (Chinese Medicines) in Normal and KK-Ay Mice.

Miura

Noda

Fukunaga³

et al. 1997

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…KK-Ay mice are obtained from a cross of black KK females with obese yellow Ay males, which are obese, hyperglycemic, hyperinsulinemic, and insulin resistant [25,26]. In our study, we choose KK-Ay mice as a model of metabolic disorders to evaluate the anti-diabetic effects of SMR.…”

Section: Methodsmentioning

confidence: 99%

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Wang

Yang

et al. 2017

Food & Nutrition Research

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The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression.

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“…KKAy mouse (also called the yellow KK mouse) was originally developed by Nishimura (1969) by crossing the KK mouse with the yellow obese mouse (Ay mouse). The KKAy mice (the yellow offspring obtained from a cross of black KK females with obese yellow Ay males) are obese, hyperglycemic, hyperinsulinemic, insulin resistant severely hypertriglyceridemic and mildly hypercholesterolemic (Fujita et al, 1983;Iwatsuka, et al, 1970), and serve as an excellent animal model for studying diabetes.…”

Section: Introductionmentioning

confidence: 99%