Antidiabetic potential of phycocyanin: Effects on KKAy mice

Ou, Yu; Lin, Lin; Yang, Xiaozhi; Pan, Qin; Cheng, Xiaodong

doi:10.3109/13880209.2012.747545

Cited by 61 publications

(43 citation statements)

References 26 publications

(23 reference statements)

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“…Moreover, numerous biological effects of C-PC have been reported, such as anti-inflammatory [7], anti-apoptotic [8], antioxidant [9], and hypolipidemic [10] activities. In addition, the literature provides some evidence on the in vivo hypoglycemic activity exerted by C-PC peptides in different animal models [11,12]. In particular, a recent study has shown that C-PC peptides activate the insulin signaling pathway and glucokinase expression in the pancreas and liver of diabetic mice [13].…”

Section: Introductionmentioning

confidence: 99%

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity

Aiello

Bollati

et al. 2020

Nutrients

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Arthrospira platensis (spirulina) is a cyanobacterium, which contains mainly two phycobiliproteins (PBP), i.e., C-phycocyanin (C-PC) and allophycocyanin (APC). In this study, PBP were hydrolyzed using trypsin, and the composition of the hydrolysate was characterized by HPLC-ESI-MS/MS. Furthermore, the potential anti-diabetic activity was assessed by using either biochemical or cellular techniques. Findings suggest that PBP peptides inhibit DPP-IV activity in vitro with a dose-response trend and an IC 50 value falling in the range between 0.5 and 1.0 mg/mL. A lower inhibition of the DPP-IV activity expressed by Caco-2 cells was observed, which was explained by a secondary metabolic degradation exerted by the same cells.

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Section: Introductionmentioning

confidence: 99%

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity

Aiello

Bollati

et al. 2020

Nutrients

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“…Studies have also shown that it has antioxidant activity against hydroxyl radicals, peroxide radicals, and DPPH radicals, and it has been used as an anti‐tumor and anti‐inflammatory agent due to its hepatoprotective properties . Finally it has potential activity against diabetes, and hypertension …”

Section: Introductionmentioning

confidence: 99%

Simultaneous production of phycobiliproteins and carbonic anhydrase by Spirulina platensis LEB‐52

et al. 2018

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The simultaneous production of carbonic anhydrase and the phycobiliproteins, C-phycocyanin and allophycocyanin, was evaluated during the cultivation of Spirulina platensis using Zarrouk's medium in its non-diluted (100 % ZM) and diluted to 20 % (v/v) (20 % ZM) forms. In both media, Spirulina simultaneously produced carbonic anhydrase and phycobiliproteins. For the phycobiliproteins' production, higher concentrations (mg/g) of C-phycocyanin and allophycocyanin were obtained when 100 % ZM was used. For carbonic anhydrase production, higher concentrations (U/g) were obtained on the 6 th day of cultivation in both culture media. 100 % ZM promoted greater productions of these bioproducts, and, for simultaneous obtainment, the cells should be harvested after 21 days, obtaining concentrations of 137.4 mg/g C-phycocyanin, 104.4 mg/g allophycocyanin, and 26.6 U/g carbonic anhydrase.

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“…With respect to the role of NADPH oxidase activation in the genesis of metabolic syndrome and type 2 diabetes, studies with rodent models of these syndromes report favorable effects of oral phycocyanin or whole spirulina on glycemic control, serum lipid profile, blood pressure, and steatohepatitis [91,92,93,94,95,96]. Also, two clinical trials, in which spirulina was administered (likely in suboptimal doses) to type 2 diabetics, likewise found modest improvements in these parameters [97,98].…”

Section: Phycocyanobilin: a Nutraceutical Inhibitor Of Nadph Oxidasementioning

confidence: 99%

Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications

McCarty

2017

Healthcare

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Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Phycocyanobilin (PhyCB), the light-harvesting chromophore in edible cyanobacteria such as spirulina, is a biliverdin derivative that shares the ability of free bilirubin to inhibit certain isoforms of NADPH oxidase. Epidemiological studies reveal that diabetics with relatively elevated serum bilirubin are less likely to develop coronary disease or microvascular complications; this may reflect the ability of bilirubin to ward off these complications via inhibition of NADPH oxidase. Oral PhyCB may likewise have potential in this regard, and has been shown to protect diabetic mice from glomerulosclerosis. With respect to oxidant-mediated uncoupling of eNOS, high-dose folate can help to reverse this by modulating the oxidation status of the eNOS cofactor tetrahydrobiopterin (BH4). Oxidation of BH4 yields dihydrobiopterin (BH2), which competes with BH4 for binding to eNOS and promotes its uncoupling. The reduced intracellular metabolites of folate have versatile oxidant-scavenging activity that can prevent oxidation of BH4; concurrently, these metabolites promote induction of dihydrofolate reductase, which functions to reconvert BH2 to BH4, and hence alleviate the uncoupling of eNOS. The arginine metabolite asymmetric dimethylarginine (ADMA), typically elevated in diabetics, also uncouples eNOS by competitively inhibiting binding of arginine to eNOS; this effect is exacerbated by the increased expression of arginase that accompanies diabetes. These effects can be countered via supplementation with citrulline, which efficiently enhances tissue levels of arginine. With respect to the loss of NO bioactivity that contributes to diabetic complications, high dose biotin has the potential to “pinch hit” for diminished NO by direct activation of soluble guanylate cyclase (sGC). High-dose biotin also may aid glycemic control via modulatory effects on enzyme induction in hepatocytes and pancreatic beta cells. Taurine, which suppresses diabetic complications in rodents, has the potential to reverse the inactivating impact of oxidative stress on sGC by boosting synthesis of hydrogen sulfide. Hence, it is proposed that concurrent administration of PhyCB, citrulline, taurine, and supranutritional doses of folate and biotin may have considerable potential for prevention and control of diabetic complications. Such a regimen could also be complemented with antioxidants such as lipoic acid, N-acetylcysteine, and melatonin—that boost cellular expression of antioxidant enzymes and glutathione—as well as astaxanthin, zinc, and glycine. The development of appropriate functional foods might make it feasible for patients to use complex nutraceutical regimens of the sort suggested here.

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Antidiabetic potential of phycocyanin: Effects on KKAy mice

Abstract: Context: Phycocyanin (PC) has been proven to have many therapeutic properties, but its effects on diabetes have not been investigated.

Cited by 61 publications

References 26 publications

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity

Simultaneous production of phycobiliproteins and carbonic anhydrase by Spirulina platensis LEB‐52

Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications

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