Breathable hydrogel dressings containing natural antioxidants for management of skin disorders

Abstract

Traditional wound dressings are not effective enough to regulate the moisture content and remove excessive exudate from the environment. Wet wound dressings formed from hydrogels such as alginate are widely used in clinical practice for treatment of skin disorders. Here, we functionalize alginate dressings with natural antioxidants such as curcumin and t-resveratrol to render them both anti-inflammatory and antibacterial. The hydrogel maintains excellent mechanical properties and oxygen permeability over time. The release rate of the compounds from the hydrogels is assessed and their impact on bacterial and cellular growth is evaluated. The antioxidant compounds act as bactericidal agents and improve cell viability. The optimal concentration of active compounds in the engineered alginate-based dressings is determined.

Flexible poly(styrene‐ethylene‐butadiene‐styrene) hybrid nanofibers for bioengineering and water filtration applications

“…Stem cells, one of important specific cells of the eukaryotic cell group, are much more complex than the bacteria, hence this could be a reason for these unexpected results. These findings were in agreement with previous studies of Comotto et al and Lundvig et al, although they used different natural compounds and cells . As it is known, biomaterials are used in regenerative medical treatments such as wound healing are expected to regenerate the cells in the damaged area and to stabilize or even reduce the microbial infections that may occur during this challenging process .…”

The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review

“…Hydrogels exhibited no toxicity to human keratinocytes (curcumin up to 150 µg/mL and t-resveratrol up to 300 µg/mL). However, curcumin-based alginate dressings were found to be more effective in bacteriostatic activity than resveratrol dressings [77].…”

“…In turn, Comotto et al [77] manufactured alginate-based hydrogels with embedded natural antioxidant compounds (curcumin and t-resveratrol). Hydrogels exhibited no toxicity to human keratinocytes (curcumin up to 150 µg/mL and t-resveratrol up to 300 µg/mL).…”

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

“…Analgesics such as morphine [138], ibuprofen [139,140], or lidocaine [141,142] are of significant interest in extensive burns, infected wounds, or in palliative medicine [1,143]. Additionally, hydrogels may also deliver growth factors [1,144,145], stem cells [2,146], peptides [147][148][149], and various drugs, such as anti-inflammatory drugs [144,150,151], amino acids [152], antioxidants [70,153], vitamins [154,155] and nutrients [135,156], which may decrease the inflammatory reaction, nourish the wound tissue, and promote wound healing [119,126]. One of the recent classes of bioactive hydrogel wound dressings is based on the healing properties provided by growth factors [1,157], cytokines [158], or cells [1,158].…”