Breast metastasis from primary lung adenocarcinoma in a young woman: A case report and literature review

Enrico, Diego; Saucedo, Sergio Raúl Recio; Bravo, I. Alda

doi:10.5306/wjco.v10.i7.269

Cited by 7 publications

(3 citation statements)

References 46 publications

(16 reference statements)

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“…It is expressed in 70% to 80% of small cell carcinomas and lung adenocarcinomas, and is rarely expressed in other types of lung cancer (26). Napsin A, which is positive in 80-90% of lung adenocarcinomas, is typically reported to be negative in breast cancer (27,28), napsin A is an alternative biomarker for the diagnosis of lung adenocarcinoma. The combination of TTF-1 and napsin A can provide maximum benefit in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Wang

Jiang

et al. 2021

Transl Lung Cancer Res

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Background: Lung cancer metastases to the breast are less common and consequently have received much less attention in clinical practice. The purpose of this study was to provide a better understanding of clinical, ultrasonographic, and immunohistochemical features of breast metastases from primary lung cancer.Methods: This retrospective case series included patients with breast metastases from primary lung cancer between January 2012 and December 2020. Clinical features, ultrasonographic characteristics, and immunohistochemical findings were evaluated in this analysis.Results: In all, 7 cases (mean ± standard deviation age: 57.4±8.3 years; range, 49-70 years) were evaluated. The maximum size of breast lesions in 6 cases ranged from 1.2 to 4.5 cm, while 1 case showed a diffused pattern. Ultrasound features of breast metastases from lung cancer were irregular (5/7, 71.4%), indistinct (6/7, 85.7%), hypoechoic (7/7, 100.0%), and parallel (6/7, 85.7%) masses without calcification.Immunohistochemical staining test was positive for thyroid transcription factor 1 (TTF-1) in all patients (7/7, 100.0%), 3 cases (3/5, 60.0%) were negative for p63, 5 cases (5/5, 100.0%) were positive for cytokeratin 7 (CK7), 4 cases (4/5, 80.0%) were positive for napsin A. Conclusions:The ultrasonographic features of lung metastases to the breast are clinically important to understand. A known history of the primary lung cancer is of great importance when evaluating patients with a breast nodule. The presence of an ipsilateral lung cancer, breast nodule and axillary lymphadenopathy should be considered with pathological and immunohistochemical data to differentiate breast metastases from a primary breast malignancy in this setting.

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Section: Discussionmentioning

confidence: 99%

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Wang

Jiang

et al. 2021

Transl Lung Cancer Res

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“…Primary breast carcinoma is the second most common malignancy in the female population; second only to skin cancer [6]. Metastasis to the breast from all cancers is an extremely uncommon event, accounting for less than 2% of breast cancers [7]. Most frequently reported metastatic cancers to the breast are malignant melanoma, lymphoma, lung, ovary, prostate, kidney, stomach, ileum, thyroid, and cervical cancer [7,8].…”

Section: Discussionmentioning

confidence: 99%

Medullary Thyroid Carcinoma Presenting as Metastatic Disease to the Breast

Kanteti

Atiya

Hein

et al. 2020

Case Reports in Pathology

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Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that is derived from C cells of the thyroid gland. It is a rare aggressive tumor, known to metastasize to lymph nodes, liver, bones, and lungs. A 41-year-old female, who presented with a breast mass, was initially diagnosed with invasive ductal carcinoma. She was also found to have a thyroid mass which was later diagnosed as MTC. On a rereview of the breast pathology, the morphologic features were strikingly similar to the MTC. Further investigation revealed that this was in fact a very rare case of MTC that had metastasized to the breast. We have identified 20 cases of MTC metastasizing to the breast in the literature that supports its occurrence as a real possibility. Albeit rare, medullary thyroid carcinoma should be considered in the differential diagnosis of a breast mass.

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“…Agrawal et al reported an incidence of 7.6 % for all metastatic malignancies of the breast [8, [10][11][12][13]. Metastasis to the breast from solid organs includes lung, ovary, prostate, kidney, stomach, ileum, thyroid, and cervix [14]. Certainly, metastasis from the contralateral breast is the commonest among all others mentioned earlier [11,15] followed by ovary then lung [8].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Adenocarcinoma Presenting as Bilateral Triple Negative Breast Cancer: Case Report and Literature Review

2022

J Med Case Rep Case Ser

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The vast majority of breast malignancies are primary lesions. However, metastasis to the breast is unusual with melanoma and hematolymphoid malignancies being the most common. In addition, metastasis from lung cancer to breast can occur, with adenocarcinoma being the most common histological subtype to metastasize. We report a 77-year-old female who presented with bilateral breast lesions, initially was thought to be bilateral mammary carcinoma, after thorough imaging workup, it was diagnosed as secondary lesions from lung adenocarcinoma. This diagnosis was confirmed by proper immunohistochemical and molecular studies on the bilateral breast biopsies. The patient was managed by tyrosine kinase inhibitors and responded well. Identification of primary versus secondary breast lesions is a very essential step in inpatient management as treatment lines can differ entirely. Performing a proper immunohistochemical panel is essential in such cases to make this differentiation in addition to the clinical and imaging correlation.

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Breast metastasis from primary lung adenocarcinoma in a young woman: A case report and literature review

Cited by 7 publications

References 46 publications

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Medullary Thyroid Carcinoma Presenting as Metastatic Disease to the Breast

Pulmonary Adenocarcinoma Presenting as Bilateral Triple Negative Breast Cancer: Case Report and Literature Review

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