Breast Carcinosarcomas

Yakan, Savaş; Sari, Erdem; Erkan, Nazif; Yıldırım, Mehmet; Vardar, Enver; Coskun, Ali; Çetin, Durmuş Ali; Eliyatkin, Nükhet

doi:10.5152/tjbh.2014.2197

Cited by 10 publications

(18 citation statements)

References 29 publications

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“…Our study showed that the 4-year BCSS rate and OS rate of carcinosarcoma was 49.6% and 46.2%, respectively. This poor clinical outcome was similar to other reports [ 8 , 13 ]. Some studies further conducted a comparison of breast carcinosarcoma with other subtypes of breast metaplastic carcinoma.…”

Section: Discussionsupporting

confidence: 92%

“…Due to the specific histologic feature, breast carcinosarcoma may have different biological characteristics when compared with IDC. Because of the rarity of breast carcinosarcoma, previous publications about this disease were a few small sample size retrospective analyses [ [8] , [9] , [10] , [11] , [12] , [13] , [14] ] and a few case reports [ [15] , [16] , [17] , [18] , [19] , [20] ]. From these limited studies, it appears that breast carcinosarcoma is always aggressive, poorly differentiated, and hormone receptor-negative [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

et al. 2020

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Objectives Carcinosarcoma of the breast is a rare disease. Its clinicopathological features and prognosis are not well defined. The aim of this study was to compare the clinicopathological features and clinical outcome between breast carcinosarcoma and breast invasive ductal carcinoma (IDC). Materials and methods Patients with breast carcinosarcoma and breast IDC were identified through the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Then a comparison was conducted between these two groups. Propensity score matching (PSM) was performed to balance the effects of baseline clinicopathological differences. The Cox proportional hazard model was used to identify potential prognostic factors of breast carcinosarcoma. Results In total, we identified 63 patients with breast carcinosarcoma and 200,596 cases with breast IDC. Comparing with IDC, breast carcinosarcoma was significantly correlated with higher grading, higher staging, larger tumor size, lower lymph node involvement, and a higher proportion of triple negative breast cancer (TNBC), suggesting a significantly worse clinical outcome. After adjusting for the uneven clinicopathological variables with PSM, significant differences were still observed between these two histology types. Subgroup analysis further showed that carcinosarcoma-TNBC has an inferior clinical outcome compared with IDC-TNBC. Finally, we identified independent prognostic factors, namely, stage, tumor size, and distant metastasis. Conclusion It is concluded that breast carcinosarcoma has distinct clinicopathological features and a significantly worse clinical outcome than common IDC.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

et al. 2020

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“…The World Health Organization’s histological classification for tumors of the breast classifies metaplastic carcinoma into pure epithelial metaplastic carcinomas, squamous cell carcinoma, adenocarcinoma with spindle cell metaplasia, adenosquamous carcinoma, mucoepidermoid carcinoma, or mixed epithelial/mesenchymal metaplastic carcinomas. The mean age at diagnosis lies between the fourth and fifth decades of life (i.e., the perimenopausal age group) [ 8 , 9 ]. The median tumor size is reported to range from 3.4 to 5.7 cm in various series [ 10 - 12 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Carcinosarcoma of the Breast Presenting as Inflammatory Carcinoma and Review of the Literature

Lakshmi¹,

Saini²,

Prakash³

et al. 2020

Cureus

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Carcinosarcoma, also known as metaplastic carcinoma, is a rare and aggressive malignant tumor. We report a case of metaplastic carcinoma presenting as inflammatory carcinoma and provide a review of the related literature. A 38-year-old breastfeeding woman presented with concerns about a painful lump in her left breast. The symptoms had been present for two months. After admission to the hospital, the triple assessment revealed findings consistent with inflammatory carcinoma of the breast. The patient underwent modified radical mastectomy. Histopathological examination revealed a gray-white tumor with a biphasic pattern with features of ductal carcinoma as well as squamous and sarcomatous differentiation. On immunohistochemistry, the neoplastic cells were positive for cytokeratin and vimentin, and focally positive for smooth muscle antigen (SMA) and negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER-2/neu). Based on histological and immunohistochemical findings, the tumor was diagnosed as carcinosarcoma. Four of eighteen dissected axillary lymph nodes were positive for metastasis. Carcinosarcoma is often a triple-negative tumor. The lack of standardized treatment protocols frequently leads to poor prognosis and can pose a diagnostic dilemma; it should be part of the differential diagnosis for a case of carcinoma of the breast presenting as inflammatory carcinoma.

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“…The mixed epithelial-mesenchymal carcinoma is further classified into carcinomas with chondroid metaplasia, carcinomas with osseous metaplasia, and carcinosar-coma (5,9,10). The histological origin of breast carcinosarcoma remains unclear, but it may be derived from stem cells with biphasic differentiation, from metaplasia of myoepithelial cells and myofibroblasts, or from preexisting fibroadenomas and phyllodes (3,14). Most evidence suggests that tumors are of myoepithelial origin with both carcinomatous and sarcomatous characteristics on histopathology (7,11,13).…”

mentioning

confidence: 99%

“…The clinical symptoms of breast carcinosarcoma are similar to invasive ductal carcinoma, and include the presence of a large painful mass, nipple discharge, nipple depression, and skin ulceration (7,8,12,14). One study reported a case of carcinosarcoma presenting as a breast abscess (15).…”

mentioning

confidence: 99%

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Guo

Sun

Zhang

et al. 2019

Iran Red Crescent Med J

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Introduction: Breast carcinosarcoma is an extremely rare breast tumor comprising two distinct components, a carcinomatous component and a non-epithelial component of mesenchymal origin. It is a subtype of metaplastic carcinoma with a difficult preoperative diagnosis. Case Presentation: We present the case of a 68-year-old postmenopausal woman with squamous metaplasia coexisting with adenocarcinoma in the epithelial component of a breast carcinosarcoma. She has been admitted in

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Breast Carcinosarcomas

Cited by 10 publications

References 29 publications

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

A Case of Carcinosarcoma of the Breast Presenting as Inflammatory Carcinoma and Review of the Literature

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

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