Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

Lin, Shuchen; Liu, Chang; Tao, Zhonghua; Zhang, Jian; Hu, Xichun

doi:10.1016/j.breast.2019.11.008

Cited by 18 publications

(17 citation statements)

References 16 publications

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“…Breast cancer with unusual histological types is a kind of specific breast cancer, which were estimated in a low prevalence and consists of diverse categories with a beyond standard number according to different guidelines, and at least eighteen histological types were currently presented and remained updated with the in-depth understanding and advances in molecular pathology [ 3 ]. Previous studies have managed to discuss the clinical features and prognosis of special histological breast cancer [ [4] , [5] , [6] , [7] ]. However, most of them were studies that merely contained a limited cohort adopted in a single medical institution, of which the characteristics of clinical profiles and prognosis could be discordant, or primarily focused on a specific category of breast lesions.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of breast cancer with special histological types: A surveillance, epidemiology, and end results database analysis

Wang

2020

The Breast

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Objectives To explore the clinicopathological features and prognosis of breast cancer with special histological types. Materials and methods The information of breast cancer patients was obtained from the Surveillance, Epidemiology, and End Results (SEER) database (2010–2016). Comparative analyses were performed to explore the difference in clinicopathological characteristics and propensity score matching (PSM) was used to weaken the effects from clinical profiles. Survival analysis was conducted to investigate the prognostic effects from histological types, and the prognostic factors of this group of patients were identified with the univariate COX proportional model. Results A total of 242863 breast cancer patients were eligible, of which 230213 individuals were ductal breast cancer (IDC) and 12650 individuals were special breast lesions, respectively. Comparatively, special breast cancer had a lower histological grade, a smaller tumor size, a lower proportion of nodal involvement and distant metastasis, in addition to a higher proportion of triple-negative subtype. The overall prognosis of special histological breast cancer was comparable to IDC, while the survival of HER2 enriched breast cancer was in favor of special breast cancer. With the PSM performance, the prognosis exhibited an inferior profile in the metaplastic breast cancer and was significantly favorable to apocrine, medullary, micropapillary, and papillary breast cancer. Conclusion This study revealed that the special histological breast cancer presented distinct clinicopathological characteristics and great heterogeneity in the prognosis among diverse histological subtypes.

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Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of breast cancer with special histological types: A surveillance, epidemiology, and end results database analysis

Wang

2020

The Breast

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“…Few epidemiological studies have reported on the incidence, demography, clinicopathology, and survival outcomes of PIOL. The Surveillance, Epidemiology, and End Results (SEER) database, which collects the incidence and survival information of cancer patients covering almost 28% of the population in the United States (US), provides valuable information on tumor characteristics and survival outcomes and is an especially vital resource for studies of rare cancers [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and survival outcomes of patients with primary intraocular lymphoma: a population-based analysis

Zhang

Chen

et al. 2022

BMC Ophthalmol

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Background Primary intraocular lymphoma (PIOL) is a rare malignancy with a poor prognosis, but its optimal therapy remains unclear. Herein, we aimed to analyze the epidemiology and survival outcomes of PIOL patients based on a population-based cancer registry in the United States. Methods Patients diagnosed with PIOL between 1992 and 2018 were identified from the Surveillance Epidemiology and End Results program. The patients were divided into two groups: those aged < 60 years and ≥ 60 years. We used the chi-squared test to analyze the differences between the two groups. Descriptive analyses were performed to analyze epidemiological characteristics and treatment. The likely prognostic factors were analyzed by Kaplan–Meier curves and Cox proportional hazards models. Results The overall incidence of PIOL was 0.23/1,000,000, which was steadily increasing from 1992 to 2018, with an annual percentage change of 2.35. In total, 326 patients (mean age, 66.1 years) with PIOL were included in this study, 72.1% were aged ≥ 60 years, 84.4% were White, and 60.4% were female. The most common pathological type was diffuse large B-cell lymphoma (DLBCL), but in patients aged < 60 years, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue was the most common. The disease-specific survival rates were 74.2% and 61.5% 5 and 10 years after diagnosis, respectively. Survival analysis found that surgery, radiation, and chemotherapy did not lead to better prognosis. Conclusions PIOL is a rare disease with poor prognosis, and its incidence has been increasing for nearly 30 years. It usually affects people aged ≥ 60 years, and DLBCL is the most common pathological type of PIOL. Patients aged < 60 years and with non-DLBCL type have improved survival. Survival of PIOL has improved in recent years.

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“…Consequently, we performed propensity score matching to eliminate the confounding factors. 16 Univariate and multivariate analyses of OS and CSS in patients with T1 stage AEGJ treated with surgery and chemoradiation after propensity score matching showed that surgery could significantly lower the risk of death compared with patients who received chemoradiation alone. However, univariate and multivariate analyses of OS and CSS in patients with T1 stage AEGJ treated with surgery and surgery+chemoradiation after propensity score matching showed similar risk of death, which suggested that chemoradiation before or after surgery could not improve patients’ survival rate.…”

Section: Discussionmentioning

confidence: 98%

Treatment Options for T1 Stage Adenocarcinoma of Esophagogastric Junction: A Real-World Retrospective Cohort Study

Zhou

Chen

et al. 2021

Cancer Control

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Background The number of patients diagnosed with T1 stage adenocarcinoma of esophagogastric junction (AEGJ) has been increasing. This study was conducted to investigate the effect of different treatment options (surgery, chemoradiation, and surgery+chemoradiation) on long-term survival in patients with T1-stage AEGJ. Methods We searched the Surveillance, Epidemiology, and End Results (SEER) database to identify the records of patients with T1-stage AEGJ between 2010 and 2018. Patient demographics and cancer parameters were compared among the three groups. The Kaplan–Meier method and Cox proportional hazard modeling were used to compare long-term survival. Results Data from 925 T1 stage AEGJ patients (surgery: n=516, surgery+chemoradiation: n=206, chemoradiation: n=203) were collected. We found that the OS and CSS rates of three treatment options had significant difference. Besides, positive nodal status also showed lower OS and CSS rat. Multivariate Cox regression analysis showed that surgery group has much lower risk of death compared with chemoradiation group and similar risk of death compared with surgery+chemoradiation group. Subgroup analysis suggested that in patients with N1–N3 status had higher OS and CSS rates in surgery+chemoradiation group. Conclusion Using SEER data, we identified a significant survival advantage with the use of surgery compared to chemoradiation in patients with T1-stage AEGJ while the long-term survival of patients after surgery+chemoradiation group was not significantly different and low risk of death in positive nodal status.

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Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

Cited by 18 publications

References 16 publications

Clinicopathological characteristics and prognosis of breast cancer with special histological types: A surveillance, epidemiology, and end results database analysis

Clinicopathological characteristics and prognosis of breast cancer with special histological types: A surveillance, epidemiology, and end results database analysis

Epidemiology and survival outcomes of patients with primary intraocular lymphoma: a population-based analysis

Treatment Options for T1 Stage Adenocarcinoma of Esophagogastric Junction: A Real-World Retrospective Cohort Study

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