Breast Carcinoma In Situ: Risk Factors and Screening Patterns

Claus, Elizabeth B.; Stowe, Meredith H.; Carter, Darryl

doi:10.1093/jnci/93.23.1811

Cited by 100 publications

(106 citation statements)

References 33 publications

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“…Previous studies that have considered differences in the effect of oral contraceptive use on histologic subtypes of breast carcinoma in situ have found a negative association with LCIS among women 20-79, 37 no association with DCIS among premenopausal women, 38 and no association with any type of breast carcinoma in situ among recently screened women 35-64 years old. 39 Although we determined that mammographic screening was not a confounder in our data, it is possible that the confounding effect of mammography differs in populations where screening is more prevalent.…”

Section: Discussionmentioning

confidence: 82%

The association between oral contraceptive use and lobular and ductal breast cancer in young women

Nyante¹,

Gammon²,

Malone³

et al. 2007

Intl Journal of Cancer

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Recent reports indicate that the incidence of lobular breast cancer is increasing at a faster rate than ductal breast cancer, which may be due to the differential effects of exogenous hormones by histology. To address this issue, we examined whether the relationship between oral contraceptive use and incident breast cancer differs between lobular and ductal subtypes in young women. A population-based sample of in situ and invasive breast cancer cases between ages 20 and 44 were recruited from Atlanta, GA; SeattlePuget Sound, WA and central New Jersey. Controls were sampled from the same areas by random-digit dialing, and were frequency matched to the expected case age distribution. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using polytomous logistic regression. Among the 100 lobular cancers, 1,164 ductal cancers, and 1,501 controls, the odds ratios for oral contraceptive ever use were 1.10 (95% CI 5 0.68-1.78) for lobular cancers and 1.21 (95% CI 5 1.01-1.45) for ductal cancers, adjusted for study site, age at diagnosis, and pap screening history. Our results suggest that the magnitude of the association between ever use of oral contraceptives and breast cancer in young women does not vary strongly by histologic subtype. These results are similar to previous studies that report little difference in the effect of oral contraceptive use on breast cancer by histology. ' 2007 Wiley-Liss, Inc.Key words: breast cancer; ductal carcinoma; lobular carcinoma; oral contraceptives Recent reports indicate that the incidence rate of invasive lobular breast cancer is increasing faster than invasive ductal breast cancer, 1-4 but few epidemiologic studies have focused on identifying breast cancer risk factors by histologic subtype. Among the studies that have, the association between combination hormone replacement therapy and risk of invasive breast cancer differed for ductal and lobular cancers in most studies, 5-10 but not all. 11 These findings suggest that the effects of other exogenous hormonal treatments, such as oral contraceptives, may also differ by histologic type.It has been consistently shown that oral contraceptive use is associated with an increased risk of breast cancer in young women, 12-25 but not older women. 21,[23][24][25] Recently, Newcomer et al. 26 reported that current oral contraceptive use, recent use, and older age at first use are associated with an increased risk of invasive lobular breast cancer, but not invasive ductal breast cancer in a population of middleaged women, suggesting that oral contraceptives may have effects related to specific histologic subtypes. It is unknown whether the associations between oral contraceptive use and breast cancer differs by histologic subtype among younger women-the age group most likely to experience increased risk of breast cancer due to oral contraceptive use. 25 To determine this, we explored the relationship of oral contraceptive use and lobular and ductal breast cancer subtypes within a population of young women. Previously, we...

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Section: Discussionmentioning

confidence: 82%

The association between oral contraceptive use and lobular and ductal breast cancer in young women

Nyante¹,

Gammon²,

Malone³

et al. 2007

Intl Journal of Cancer

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“…Other factors that represent hormonal exposures (age at menarche, parity, and HRT) have also been associated with BCIS risk. 4 High levels of moderate and vigorous physical activity before menarche may delay the onset of menses. 25,26 During a woman's reproductive years, strenuous exercise activity is associated with an increased likelihood of secondary amenorrhea, irregular or anovulatory menstrual cycles, and shortened luteal phases of the menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

Lifetime recreational exercise activity and risk of breast carcinoma in situ

Patel

Press

Meeske

et al. 2003

Cancer

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The aim of this study is the creation of an empirical model that can be used to predict the viscosity of a semicrystalline polymer melt for polymer process control. We have developed an empirical viscosity equation from both analysis and experimentation that takes into consideration the effect of temperature on both the flow behavior and the consistency index in the power law. The analysis is based on previously published literature, whereas the experimental data have been obtained from both the literature and laboratory investigations. The coefficients of the empirical model for low‐density polyethylene and polypropylene have been obtained from the experimental data derived from capillary rheometer measurements in the laboratory. This empirical model is able to produce results matching the experimental data with remarkable accuracy. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 3045–3057, 2003

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“…Selected factors associated with breast cancer risk [age, age at menarche, parity, body mass index (BMI), number of biopsies for benign breast disease, family history of breast cancer in a first-degree relative, and menopausal status; refs. [34][35][36] were covariates for the study and were obtained with an interviewer-administered questionnaire.…”

mentioning

confidence: 99%

Role of Physical Activity in Modulating Breast Cancer Risk as Defined byAPCandRASSF1APromoter Hypermethylation in Nonmalignant Breast Tissue

Coyle

Xie²,

Lewis

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Physical activity reduces breast cancer risk. Promoter hypermethylation of the tumor suppressor genes APC and RASSF1A, which is potentially reversible, is associated with breast cancer risk. We conducted a cross-sectional study in 45 women without breast cancer to determine the association of physical activity with promoter hypermethylation of APC and RASSF1A in breast tissue. We used quantitative methylation-specific PCR to test the methylation status of APC and RASSF1A, and questionnaires to assess study covariates and physical activity (measured in metabolic equivalent hours per week). In univariate analyses, the study covariate, benign breast biopsy number, was positively associated with promoter hypermethylation of APC (P = 0.01) but not RASSF1A. Mulitvariate logistic regression indicated that, although not significant, physical activities for a lifetime [odds ratio (OR), 0.57; 95% confidence interval (95% CI), 0.22-1.45; P = 0.24], previous 5 years (OR, 0.62; 95% CI, 0.34-1.12; P = 0.11), and previous year (OR, 0.72; 95% CI, 0.43-1.22; P = 0.22) were inversely related to promoter hypermethylation of APC but not RASSF1A for all physical activity measures. Univariate logistic regression indicated that physical activities for a lifetime, previous 5 years, and previous year were inversely associated with benign breast biopsy number, and these results were approaching significance for lifetime physical activity (OR, 0.41; 95% CI, 0.16-1.01; P = 0.05) and significant for physical activity in the previous 5 years (OR, 0.57; 95% CI, 0.34-0.94; P = 0.03). The study provides indirect evidence supporting the hypothesis that physical activity is inversely associated with promoter hypermethylation of tumor suppressor genes, such as APC, in nonmalignant breast tissue. (Cancer Epidemiol Biomarkers Prev 2007;16(2):192 -6)

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Breast Carcinoma In Situ: Risk Factors and Screening Patterns

Abstract: The risk factors associated with DCIS and LCIS are similar to those associated with invasive breast cancer. Diagnosis of DCIS is associated with increased mammography screening.

Cited by 100 publications

References 33 publications

The association between oral contraceptive use and lobular and ductal breast cancer in young women

The association between oral contraceptive use and lobular and ductal breast cancer in young women

Lifetime recreational exercise activity and risk of breast carcinoma in situ

Role of Physical Activity in Modulating Breast Cancer Risk as Defined byAPCandRASSF1APromoter Hypermethylation in Nonmalignant Breast Tissue

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