Breast Cancer Stem Cells: A Novel Therapeutic Target

Gangopadhyay, Sudeshna; Nandy, Argha; Hor, Pooja; Mukhopadhyay, Ashis

doi:10.1016/j.clbc.2012.09.017

Cited by 110 publications

(106 citation statements)

References 84 publications

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“…Therefore, the downregulation of the wnt/β-catenin self-renewal pathway may be a potential target of the Huaier extract. The inhibitory effect of Huaier extract on CSCs was also found to be partly dependent on the inactivation of the Hh pathway which is associated with both normal mammary gland development and breast cancer progression (73,75). After treatment with Huaier extract, the expression of Gli1 was obviously declined, showing that Huaier extract was highly effective to eradicate breast (CSCs) through regulating Hh signaling (73).…”

Section: Inhibition Of Cancer Stem Cells By Huaiermentioning

confidence: 93%

The anticancer effect of Huaier (Review)

Song

Zhang

2015

Oncology Reports

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Abstract. Trametes robiniophila Murr. (Huaier) is a sandy beige mushroom found on the trunks of trees and has been widely used in traditional Chinese medicine (TCM) for ~1,600 years. The anticancer effects of Huaier have attracted increasing worldwide interest in recent years. Accumulating evidence suggests that the anticancer mechanism of Huaier may be associated with various biological activities, such as inhibition of cell proliferation, anti-metastasis, interference with tumor angiogenesis and tumor-specific immunomodulatory effect. Animal and experimental studies suggest that Huaier is a promising anticancer agent. Further clinical research is warranted to illustrate the untapped chemopreventive and therapeutic potential of Huaier either alone or in conjunction with existing therapies.

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Section: Inhibition Of Cancer Stem Cells By Huaiermentioning

confidence: 93%

The anticancer effect of Huaier (Review)

Song

Zhang

2015

Oncology Reports

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“…40 Phenotypic and functional characteristics of both normal mammary stem cells and BCSC are difficult to study in traditional two-dimensional culture models, because these cells continually undergo differentiation. Propagation of BCSC in nonadherent spheres has yielded valuable information regarding pathways required for stem cell self-renewal.…”

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confidence: 99%

Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds

Sims‐Mourtada¹,

Niamat²,

Samuel³

et al. 2014

IJN

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A small population of highly tumorigenic breast cancer cells has recently been identified. These cells, known as breast-cancer stem-like cells (BCSC), express markers similar to mammary stem cells, and are highly resistant to chemotherapy. Currently, study of BCSC is hampered by the inability to propagate these cells in tissue culture without inducing differentiation. Recently, it was reported that proliferation and differentiation can be modified by culturing cells on electrospun nanofibers. Here, we sought to characterize the chemoresistance and stem-like properties of breast cancer cell lines grown on nanofiber scaffolds. Cells cultured on three-dimensional templates of electrospun poly( ε -caprolactone)-chitosan nanofibers showed increases in mammary stem cell markers and in sphere-forming ability compared with cells cultured on polystyrene culture dishes. There was no increase in proliferation of stem cell populations, indicating that culture on nanofibers may inhibit differentiation of BCSC. The increase in stemness was accompanied by increases in resistance to docetaxel and doxorubicin. These data indicate that BCSC populations are enriched in cells cultured on electrospun poly( ε -caprolactone)-chitosan nanofibers, scaffolds that may provide a useful system to study BCSC and their response to anticancer drug treatment.

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“…It has been shown that HER2 expression is closely associated with the recurrence, metastasis, and poor prognosis of BC (27). FISH can detect the expression of the HER2 gene in BC tissue, which can help clarify the Another study has shown that CD44 is an important marker of BCSCs (29). Therefore, many researchers in China and abroad isolate CD44 + /CD24 -cells during sorting, which are considered bona fide BCSCs.…”

Section: Discussionmentioning

confidence: 99%

Involvement of breast cancer stem cells in tumor angiogenesis

Wang

et al. 2017

Oncol Lett

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Abstract. The aim of the present study was to investigate the role of breast cancer stem cells (BCSCs) in the angiogenesis of breast cancer tumors. The expression levels of mutant p53, cluster of differentiation (CD)31, vascular endothelial factor (VEGF), in addition to human epidermal growth factor (HER)2, were detected in the blood vessels of human breast cancer (BC) tissue samples. CD44 + /CD24 -/low cells were selected from single-cell suspensions of BC tissues to assess the expression of CD31 and CD105, in addition to the ability of these cells to metabolize acetylated low-density lipoprotein (Ac-LDL). Furthermore, vascular-like structures were observed histologically. Mutant p53, CD31 and VEGF were all expressed in these tissues. CD44+ cells comprised 7.5±2.6 and 94.3±4.7% of the cell population prior to and following sorting, respectively. CD24 + cells comprised 48.2±9.4 and 4.3±4% of the cell population prior to and following sorting, respectively. A low proportion of CD24 + cells corresponded to a high proportion of CD24 -/low cells. The percentages of CD105 + and CD31 + glomus cells in the mammary gland were 4.5±0.9 and 6.2±1.3%, respectively, and following passaging for three generations, these increased to 79.6±9.3 and 84.1±10.7%, respectively (P<0.05). Cells were cultured using an endothelial cell culture system, and they internalized DiL-Ac-LDL. Here, vascular endothelial cells formed vascular-like structures, whereas the control group demonstrated no such structures. Overall, the results suggest that BCSCs-derived endothelial cells may contribute to tumor angiogenesis.

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Breast Cancer Stem Cells: A Novel Therapeutic Target

Cited by 110 publications

References 84 publications

The anticancer effect of Huaier (Review)

The anticancer effect of Huaier (Review)

Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds

Involvement of breast cancer stem cells in tumor angiogenesis

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