The anticancer effect of Huaier (Review)

Song, Xinwei; Li, Yaming; Zhang, Hanwen

doi:10.3892/or.2015.3950

Cited by 66 publications

(61 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A proteoglycan isolated from Poria cocos induced the activation of RAW 264.7 cells through up-regulation of TNF␣ (31). Additionally, it has been reported that the immunomodulatory effect is one of underlying mechanisms of anti-tumor activity of Huaier (2,7,32). Our work showed that the proteoglycan TPG-1 isolated from Huaier significantly increased the production of NO, TNF␣, and IL-6 in RAW264.7 cells.…”

Section: Cancer Immunotherapy Of Tpg-1 Via Tlr4 -Nf-b/mapk Signalingsupporting

confidence: 59%

“…(Huaier) is a medicinal fungus that has been applied for disease treatment for more than 1600 years in China. Numerous studies have shown that Huaier exhibits good clinical efficacy in the treatment of liver cancer, gastric cancer, prostate cancer, colon cancer, breast cancer, and lung cancer (1)(2)(3)(4). There is evidence that some polysaccharides of Huaier aqueous extract show anti-tumor and immunomodulatory activities.…”

mentioning

confidence: 99%

See 1 more Smart Citation

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

Yang

Fan

Chen

et al. 2019

Journal of Biological Chemistry

View full text Add to dashboard Cite

Edited by Xiao-Fan WangTrametes robiniophila Murr. (Huaier) is a mushroom with a long history of use as a medicinal ingredient in China and exhibits good clinical efficacy in cancer management. However, the antitumor components of Huaier and the underlying molecular mechanisms remain poorly understood. Here, we isolated a proteoglycan with a molecular mass of ϳ5.59 ؋ 10 4 Da from Huaier aqueous extract. We named this proteoglycan TPG-1, and using FTIR and additional biochemical analyses, we determined that its total carbohydrate and protein compositions are 43.9 and 41.2%, respectively. Using biochemical assays and immunoblotting, we found that exposing murine RAW264.7 macrophages to TPG-1 promotes the production of nitric oxide (NO), tumor necrosis factor ␣ (TNF␣), and interleukin-6 (IL-6) through Toll-like receptor 4 (TLR4)-dependent activation of NF-B and mitogen-activated protein kinase (MAPK) signaling. Of note, the TPG-1 treatment significantly inhibited the tumorigenesis of human hepatoma HepG2 cells likely at least in part by increasing serum levels of TNF␣ and promoting leukocyte infiltration into tumors in nude mice. TPG-1 also exhibited good antitumor activity in hepatoma H22-bearing mice and had no obvious adverse effects in these mice. We conclude that TPG-1 exerts antitumor activity partially through an immune-potentiating effect due to activation of the TLR4 -NF-B/MAPK signaling cassette. Therefore, TPG-1 may be a promising candidate drug for cancer immunotherapy. This study has identified the TPG-1 proteoglycan as an antitumor agent and provided insights into TPG-1's molecular mechanism, suggesting a potential utility for applying this agent in cancer therapy.

show abstract

Section: Cancer Immunotherapy Of Tpg-1 Via Tlr4 -Nf-b/mapk Signalingsupporting

confidence: 59%

mentioning

confidence: 99%

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

Yang

Fan

Chen

et al. 2019

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…It has been widely used in Chinese Medicine for nearly 1600 years 11. Huaier granule, the aqueous product of Huaier extract, is an approved TCM by Chinese State Food and Drug Administration (SFDA) to be used alone or combined with other drugs in treatment of leukaemia, osteosarcoma, malignant lymphoma, breast cancer, lung cancer, rectal cancer, liver cancer, gastric cancer, colon cancer and pancreatic adenocarcinoma, respectively 12. Recent studies show that the active ingredient in Huaier extract is a proteoglycan, composed of 41.5% polysaccharides, 12.93% amino acids and 8.72% water 13.…”

Section: Introductionmentioning

confidence: 99%

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

Chang

Shu²,

Laurence

et al. 2018

Gut

155

125

View full text Add to dashboard Cite

show abstract

“…Huang Qi Huai (HQH) granules, with the brand name Huan Er Jin is primarily composed of trametes robiniophila murr (Huaier), Chinese wolfberry fruit and polygonatum. Huaier, which is rich in polysaccharides, has been applied in traditional Chinese medicine for approximately 1600 years [9]. Pharmacological studies suggest that trametes robiniophila murr is a biological response modifier and can stimulate many elements of the immune system to enhance immunity.…”

Section: Introductionmentioning

confidence: 99%

Huang Qi Huai Granules Induce Apoptosis in Acute Lymphoblastic Leukemia Cells through the Akt/FoxO1 Pathway

Han¹,

Lin²,

Zeng³

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: In recent years, a traditional Chinese medicine named Huang Qi Huai (HQH) has been frequently used in China for solid tumor therapy. However, the role of HQH on leukemia cells and its underlying mechanisms have not been elucidated. In this study, we investigated the effect of HQH on the proliferation and apoptosis of acute lymphoblastic leukemia (ALL) cell lines. Methods: Sup-B15 and Nalm-6 cells were treated with gradient doses of HQH for 24, 48 or 72 h. Cell viability was measured using a CCK8 assay and cell cycle distribution and apoptosis levels were analyzed using flow cytometry. Western blotting was used to assess the levels of proteins associated with the apoptotic pathway. Results: The results revealed that cell survival decreased significantly with increasing concentrations of HQH. HQH induced G2 cell-cycle arrest and cell apoptosis in a dose-dependent manner. HQH inhibited phosphorylated-Akt, phosphorylated- FoxO1 and Bcl2 expression and upregulated Bim, cleaved-caspase-3 and Bax expression in a dose-dependent manner, which suggests that HQH induces the apoptosis of ALL cells via the Akt/FoxO1 pathway. Conclusion: HQH is a potential complementary agent for the treatment of acute lymphoblastic leukemia.

show abstract

The anticancer effect of Huaier (Review)

Cited by 66 publications

References 73 publications

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

Huang Qi Huai Granules Induce Apoptosis in Acute Lymphoblastic Leukemia Cells through the Akt/FoxO1 Pathway

Contact Info

Product

Resources

About