Breast cancer: presentation, investigation and management

Katsura, Chie; Ogunmwonyi, Innocent; Kankam, Hadyn; Saha, Sunita

doi:10.12968/hmed.2021.0459

Cited by 116 publications

(58 citation statements)

References 11 publications

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“…Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer mortality in females worldwide [ 48 ]. Broadly, breast cancer patients can be classified into estrogen receptor positive (ER+)—corresponding to 70% of total cases—or estrogen receptor negative (ER−) [ 49 , 50 ].…”

Section: Lncrna H19 Impairs Chemo and Radiotherapy In Breast Cancermentioning

confidence: 99%

LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis

García-Padilla

Lozano-Velasco

Muñoz-Gallardo

et al. 2022

IJMS

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Various treatments based on drug administration and radiotherapy have been devoted to preventing, palliating, and defeating cancer, showing high efficiency against the progression of this disease. Recently, in this process, malignant cells have been found which are capable of triggering specific molecular mechanisms against current treatments, with negative consequences in the prognosis of the disease. It is therefore fundamental to understand the underlying mechanisms, including the genes—and their signaling pathway regulators—involved in the process, in order to fight tumor cells. Long non-coding RNAs, H19 in particular, have been revealed as powerful protective factors in various types of cancer. However, they have also evidenced their oncogenic role in multiple carcinomas, enhancing tumor cell proliferation, migration, and invasion. In this review, we analyze the role of lncRNA H19 impairing chemo and radiotherapy in tumorigenesis, including breast cancer, lung adenocarcinoma, glioma, and colorectal carcinoma.

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Section: Lncrna H19 Impairs Chemo and Radiotherapy In Breast Cancermentioning

confidence: 99%

LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis

García-Padilla

Lozano-Velasco

Muñoz-Gallardo

et al. 2022

IJMS

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show abstract

“…As an example, it is worth to mention Carlson's study on the effectiveness of MCBR (mindfulness based cancer recovery) and SET (supportive-expressive therapy) in patients with breast cancer. Breast cancer is characterized by the highest incidence among all malignant neoplasms in women in highly developed countries [10]. MCBR therapy was found to be better than SET at improving stress levels, quality of life, and social support [11].…”

Section: Mindfulness Is Used In Mbi (Mindfulness Based Interventions)...mentioning

confidence: 99%

Mindfulness sessions delivered via smartphone applications and their potential benefits

Nowakowska

Lewkowicz

Karolina

et al. 2022

J Educ Health Sport

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Mindfulness, as a practice of focusing one’s attention on the present moment without evaluating, is used in mindfulness based interventions (MBI) therapy. Traditionally, these sessions are conducted in person. At this moment, we are witnessing a global trend in which patients are turning to technology and are looking for alternative, more convenient solutions. There are studies assessing the effectiveness of mindfulness training conducted in a new unconventional way, which is using an application installed on patient's smartphone. This paper discusses possible benefits of online conducted mindfulness sessions.

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“…With the continuous development of new targets and drugs for the treatment of breast cancer and the success of clinical trials involving new treatment protocols, the treatment and prognosis of breast cancer have advanced greatly (3)(4)(5). However, patients with advanced or high-risk conditions continue to have poor treatment outcomes and prognoses (6,7). Early detection and rapid treatment would be very beneficial for patients with breast cancer, as they would increase their prognosis (8).…”

Section: Introductionmentioning

confidence: 99%

Identification of cuproptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in breast cancer

Zhang

Wang

et al. 2022

Front. Immunol.

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Breast cancer (BC) is now the most frequent and lethal cancer among women. Cuproptosis is a newly identified programmed cell death process that has been connected to tumor therapeutic sensitivity, patient outcomes, and the genesis of cancer. Cuproptosis-related genes (CRGs) are involved in breast cancer, although their roles and potential mechanisms are still unclear. First, we examined the effect of gene mutations and copy number changes on overall survival in 1168 breast cancer samples. Breast cancer patients were split into two molecular categories as determined by the variation in CRG based on clinicopathological traits, overall survival, and cell-infiltrating traits in tumor microenvironments. In addition, we created and validated a CRG score to calculate breast cancer patients' OS. Finally, we created a comprehensive nomogram for the clinical use of the CRG score. Patients whose CRG scores were low showed increased odds of developing OS, a larger mutation load, and immunological activation than those with high CRG scores. The CRG score, the cancer stem cell index, and the responsiveness to chemotherapy or targeted therapies were also shown to be statistically significantly correlated. Our thorough examination of CRGs in breast cancer patients demonstrated that they may be useful predictors of prognosis, clinical characteristics, and tumor microenvironment. These findings provide fresh insight into CRGs in breast cancer and might inspire brand-new approaches to both diagnosing and treating patients there.

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Breast cancer: presentation, investigation and management

Cited by 116 publications

References 11 publications

LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis

LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis

Mindfulness sessions delivered via smartphone applications and their potential benefits

Identification of cuproptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in breast cancer

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