Breast Cancer Metastasis to the Stomach Resembling Early Gastric Cancer

Eo, Wan Kyu

doi:10.4143/crt.2008.40.4.207

Cited by 17 publications

(24 citation statements)

References 13 publications

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“…Other authors showed that the most common type of gastric metastasis of breast cancer (73-83%) is linitis plastica (34)(35)(36).…”

Section: Diagnosticmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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patologic corect, imunohistochimia ne oferă un diagnostic de certitudine. Introducerea unui protocol de supraveghere endoscopică pentru pacienţii cu cancer lobular de sân ar putea fi o propunere pentru detectarea precoce a metastazelor gastrice care să permită o terapie adecvată.Cuvinte cheie: metastaze gastrice, cancer de sân lobular, teste imunohistochimice, endoscopie superioară Abstract Introduction: The predilection of lobular invasive breast cancer metastasis for the stomach is a topic that has succumbed to various assumptions over the time. Background and Aims: Gastric metastasis of lobular breast cancer is unusual and it can be diagnosed after a long period of time from primary tumor diagnosis. The aim of this study was to review current knowledge regarding the current methods of diagnosis and treatment of gastric metastasis of breast cancer. Methods: A systematic literature search was performed in the Pub-Med -Medline database using the terms "gastric metastasis of lobular breast cancer" and "gastric metastasis features" to identify articles relevant to gastric metastasis of lobular breast cancer. Results: Several papers have shown that the topic is rarely presented in the form of case presentations or miniseries by summing up sporadic cases. Due to its rarity and metastasis specificity as host type and appearance after latency of lobular breast cancer makes its gastric metastasis considered atypical and occasionally confused with a primary stomach malignancy. The most recent articles present the immunohistochemical diagnostic criteria of this clinical entity and a new therapeutic approach. Conclusion: At patients with gastric metastasis of lobular breast cancer, obtaining pathologic material and biopsies interpretation can be a real challenge for getting a correct pathologic diagnosis, immunohistochemistry gives us definite diagnosis. The introduction of an endoscopic surveillance protocol for patients with lobular breast cancer could be a proposal for the detection of early gastric metastases allowing for appropriate therapy.

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“…Other authors showed that the most common type of gastric metastasis of breast cancer (73-83%) is linitis plastica (34)(35)(36).…”

Section: Diagnosticmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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“…The endoscopic pattern usually is confounded with a gastrointestinal cancer. The most frequent pattern of spread is diffuse infiltration 12–14. The median time to development of metastases is approximately 4 or 5 years 13…”

Section: Discussionmentioning

confidence: 99%

Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms

Guzmán¹,

Espinosa²,

Cervera³

et al. 2016

BCTT

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Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells.

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“…This type of metastasis is generally visualized via radiography as a rigid and thickened gastric wall, and the macroscopic features can include enlarged mucosal folds, erosions, and/or polypoid lesions [5, 7, 8]. However, metastasis from a breast tumor can also appear as a localized lesion in the stomach, which can mimic early-stage gastric cancers, and present as flat elevated, erosive, ulcerative, or polypoid lesions [3, 7–9]. …”

Section: Discussionmentioning

confidence: 99%

“…To reach an accurate diagnosis, immunostaining is recommended to differentiate between primary gastric cancer and breast cancer metastasis to the stomach [3, 5]. Immunostaining for ER and PgR has been reported to be useful for diagnosing metastatic tumors from breast cancer, although 32% and 12% of primary gastric cancer cases are positive for ER and PgR, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Breast Cancer Metastasis to the Stomach That Was Diagnosed after Endoscopic Submucosal Dissection

Kita

Furukawa

Iwamuro

et al. 2016

Case Reports in Gastrointestinal Medicine

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A 52-year-old woman presented with stage IIB primary breast cancer (cT2N1M0), which was treated using neoadjuvant chemotherapy (epirubicin, cyclophosphamide, and paclitaxel). However, the tumor persisted in patchy areas; therefore, we performed modified radical mastectomy and axillary lymph node dissection. Routine endoscopy at 8 months revealed a depressed lesion on the gastric angle's greater curvature, and histology revealed signet ring cell proliferation. We performed endoscopic submucosal dissection for gastric cancer, although immunohistochemistry revealed that the tumor was positive for estrogen receptor, mammaglobin, and gross cystic disease fluid protein-15 (E-cadherin-negative). Therefore, we revised the diagnosis to gastric metastasis from the breast cancer.

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Breast Cancer Metastasis to the Stomach Resembling Early Gastric Cancer

Cited by 17 publications

References 13 publications

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms

Breast Cancer Metastasis to the Stomach That Was Diagnosed after Endoscopic Submucosal Dissection

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