Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms

Guzmán, J Carlos Villa; Espinosa, Jose Rodrigo; Cervera, Raimundo; Delgado, Manuel Lorenzo; R, Patón; García, JM Cordero

doi:10.2147/bctt.s79506

Cited by 21 publications

(21 citation statements)

References 29 publications

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“…However, there is significant variability in SSRP1 and SPT16 levels in clinical samples of BrCa [1], [2]. To understand the functional significance of high FACT expression, we compared the sensitivity of BrCa cells with different basal levels of FACT to FACT inhibition.…”

Section: Resultsmentioning

confidence: 99%

Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells

et al. 2017

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Although breast cancer (BrCa) may be detected at an early stage, there is a shortage of markers that predict tumor aggressiveness and a lack of targeted therapies. Histone chaperone FACT, expressed in a limited number of normal cells, is overexpressed in different types of cancer, including BrCa. Recently, we found that FACT expression in BrCa correlates with markers of aggressive BrCa, which prompted us to explore the consequences of FACT inhibition in BrCa cells with varying levels of FACT.FACT inhibition using a small molecule or shRNA caused reduced growth and viability of all BrCa cells tested. Phenotypic changes were more severe in high- FACT cells (death or growth arrest) than in low-FACT cells (decreased proliferation). Though inhibition had no effect on the rate of general transcription, expression of individual genes was changed in a cell-specific manner. Initially distinct transcriptional profiles of BrCa cells became similar upon equalizing FACT expression. In high-FACT cells, FACT supports expression of genes involved in the regulation of cell cycle, DNA replication, maintenance of an undifferentiated cell state and regulated by the activity of several proto-oncogenes. In low-FACT cells, the presence of FACT reduces expression of genes encoding enzymes of steroid metabolism that are characteristic of differentiated mammary epithelia.Thus, we propose that FACT is both a marker and a target of aggressive BrCa cells, whose inhibition results in the death of BrCa or convertion of them to a less aggressive subtype.

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Section: Resultsmentioning

confidence: 99%

Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells

et al. 2017

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“…For GIT metastasis originating from primary BC, the stomach is one of the most frequently affected organs [15]. Therefore, the discrimination of both tumors is essential to determining a patient’s clinical course and treatment outcome.…”

Section: Discussionmentioning

confidence: 99%

HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort

et al. 2017

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BackgroundAmong the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificity and can be easily applied in routine laboratory work. An example of this challenge is distinguishing gastric metastases originating from breast cancer from a gastric primary tumor. Hepatocyte nuclear factor 4 alpha (HNF4A) has been suggested as a potential marker in these cases.The aim of this study was to analyze the expression of HNF4A, estrogen receptor (ER), progesterone receptor (PR) and gross cystic disease fluid protein 15 (GCDFP-15) in a Brazilian cohort.MethodsWe performed immunohistochemistry analysis of HNF4A, ER, PR and GCDFP-15 in 126 patients divided into three cohorts: primary breast cancer, primary gastric cancer and both types of tumors.ResultsOur data confirmed the sensitivity and specificity of the HNF4A marker compared to other currently used clinical markers.ConclusionHNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in populations with high genetic diversity.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-017-0635-2) contains supplementary material, which is available to authorized users.

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“…We report a case of Ewing's sarcoma with stomach metastasis. Gastric metastasis is very rare and was reported in very few breast malignancies and malignant melanomas [9, 10]. Few case reports of primary extraosseous Ewing's sarcoma of the stomach were described [11].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Gastric Metastasis in Ewing’s Sarcoma of the Femur

Koti

Backianathan

Sebastian

et al. 2019

Case Reports in Oncological Medicine

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The stomach is a very unusual site of metastasis. Published reports on metastatic lesion in the stomach is generally limited to single case reports and case series. Gastric metastasis in an Ewing’s sarcoma is extremely rare and has been reported in English literature but once to our knowledge. We present a case report of Ewing’s sarcoma of the right proximal femur metastasizing to the stomach. A young female treated for Ewing’s sarcoma of the femur in 2012 presented with gastric metastasis after four years of disease-free interval. She was treated with irinotecan-based chemotherapy followed by total gastrectomy with esophagojejunal anastomosis and radiation therapy. At one-year follow-up, she was disease free.

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Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms

Cited by 21 publications

References 29 publications

Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells

Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells

HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort

A Rare Case of Gastric Metastasis in Ewing’s Sarcoma of the Femur

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