Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Abstract

patologic corect, imunohistochimia ne oferă un diagnostic de certitudine. Introducerea unui protocol de supraveghere endoscopică pentru pacienţii cu cancer lobular de sân ar putea fi o propunere pentru detectarea precoce a metastazelor gastrice care să permită o terapie adecvată.Cuvinte cheie: metastaze gastrice, cancer de sân lobular, teste imunohistochimice, endoscopie superioară Abstract Introduction: The predilection of lobular invasive breast cancer metastasis for the stomach is a topic that has succumbed to various assumptions over the time. Background and Aims: Gastric metastasis of lobular breast cancer is unusual and it can be diagnosed after a long period of time from primary tumor diagnosis. The aim of this study was to review current knowledge regarding the current methods of diagnosis and treatment of gastric metastasis of breast cancer. Methods: A systematic literature search was performed in the Pub-Med -Medline database using the terms "gastric metastasis of lobular breast cancer" and "gastric metastasis features" to identify articles relevant to gastric metastasis of lobular breast cancer. Results: Several papers have shown that the topic is rarely presented in the form of case presentations or miniseries by summing up sporadic cases. Due to its rarity and metastasis specificity as host type and appearance after latency of lobular breast cancer makes its gastric metastasis considered atypical and occasionally confused with a primary stomach malignancy. The most recent articles present the immunohistochemical diagnostic criteria of this clinical entity and a new therapeutic approach. Conclusion: At patients with gastric metastasis of lobular breast cancer, obtaining pathologic material and biopsies interpretation can be a real challenge for getting a correct pathologic diagnosis, immunohistochemistry gives us definite diagnosis. The introduction of an endoscopic surveillance protocol for patients with lobular breast cancer could be a proposal for the detection of early gastric metastases allowing for appropriate therapy.

Secondary Alopecia Neoplastica Mimicking Alopecia Areata following Breast Cancer

“…GI metastasis may occur in several types of cancer, with breast cancer being the second most common after lung cancer [10]. However, the stomach and bowel and rare metastatic sites for breast cancer.…”

“…However, the stomach and bowel and rare metastatic sites for breast cancer. The incidence of stomach metastasis is about 0.2-1.7% from all types of cancer and 2-18% from breast cancer [10,11]. Colonic involvement is rarer than gastric involvement, present in 3-12% of GI tract breast cancer metastatic cases [12].…”

Gastric metastases from invasive lobular carcinoma of the breast: Case report

“…IDC usually metastasize to local and distant lymph nodes, liver, lungs, brain, and bone [3 , 4] . In contrast, ILC shows a distinct systemic metastatic pattern and has a higher incidence of metastases to the gastrointestinal tract, gynecological organs, meninges, pleura, peritoneum, and skin [1] , [2] , [3] , [4] , [5] , [6] .…”

“…The 2 most common histologic types of invasive breast cancer are invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC). ILC corresponds to less than 10% of all malignant breast tumors [1 , 2] and has a higher rate of bilaterality and multifocality than does IDC. It is the most difficult tumor to diagnose on mammography, with architectural distortion being the most frequent alteration.…”

“…Breast cancer is one of the most common malignancies that metastasizes to the gastrointestinal tract, along with melanoma and lung carcinoma [1] . However, gastric metastases of lobular breast cancer are uncommon, with a reported incidence varying between 2.8% and 27% [2] .…”