Breast cancer metastasis to a mandibular extraction socket: A case report and discussion on clinical detection of metastasis to the oral cavity

Erickson, Helaman Paul; Hamao-Sakamoto, Aya

doi:10.1016/j.ajoms.2013.01.002

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A review of articles showed that numb chin syndrome (NCS) is also a sign of oral metastasis. NCS is a condition affecting the areas supplied by mental or inferior alveolar nerves, it is marked by hypoesthesia, paraesthesia, and infrequently by pain over the chin [ 17 ]. Since these symptoms are characteristic of other dental diseases and also because there are varied presentations of oral cavity metastasis, they can be misdiagnosed.…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Mandibular Metastasis From a Breast Carcinoma

Vetri¹,

Jacob²,

Kannichamy³

et al. 2022

Cureus

View full text Add to dashboard Cite

Despite the rise in the number of cases of breast cancer in recent years, clinical diagnosis of a primary tumor in cases presenting with metastasis to the oral cavity poses a challenge in modern medicine because of its rare presentation.We report a case of breast cancer which presented as a painless swelling in the jaw. A 37-year-old multiparous woman consulted her dentist with complaints of toothache and swelling over the right cheek. On examination, she was diagnosed with dental caries and an orthopantomogram (OPG) was done to evaluate the swelling which revealed an area of rarefaction with an irregular margin on the right angle of the mandible. With suspicion of malignancy, the head, neck, oral and pharyngeal regions were thoroughly inspected and palpated. An ultrasonogram (USG) of the neck was done, which was normal and a core needle biopsy of the oral swelling was performed which showed metastatic carcinomatous deposits with pancytokeratin (PAN-CK) positivity, estrogen receptor (ER) positivity, and the Ki-67 value was 10% to 20% which was suggestive of breast carcinoma metastasis. Thereafter, the patient was referred for a surgeon's opinion. A breast examination was then done which revealed a lump in the right breast with a retracted nipple. A core needle biopsy of the lump revealed that it was ER and progesterone receptor (PR) positive and human epidermal growth factor receptor 2 (HER-2/neu) negative which confirmed the clinical diagnosis of breast cancer.Since the incidence of oral metastatic tumors is low, the likelihood of an early diagnosis of the distant primary tumor is reduced. Hence, all lesions of the oral cavity should be evaluated with due diligence considering the possibility of it being secondary metastases from distant tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

A Case Report on Mandibular Metastasis From a Breast Carcinoma

Vetri¹,

Jacob²,

Kannichamy³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Other symptoms such as swelling, the presence of an intraoral mass, loose or extruded teeth, cortical expansion, regional lymphadenopathy, gum irritation, ulceration, exophytic growth, halitosis, numbness or paresthesia of the lower lip, and trismus might be clues [ 14 ]. “Numb chin” syndrome is one of the symptoms raising suspicion of a metastatic process [ 15 ]. Occasionally, patients present with nonspecific clinical features; therefore, a thorough medical interview of patients with a known malignancy is essential.…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma metastasis to the cheek: a case report

et al. 2022

View full text Add to dashboard Cite

Background Breast carcinoma is a common tumor in women, but it rarely metastasizes to the oral region. Furthermore, metastases to the oral region occur mainly to the maxillary and mandibular bone and rarely to soft tissue. Case presentation We describe a case of breast cancer metastasis to the buccal area. Examination of the right buccal mass of a 66-year-old Japanese woman was suggestive of breast cancer metastasis, and a breast lump was detected. Since receiving hormone-based treatment, the patient has survived more than 5 years and is now in remission. Conclusions An oral metastatic lesion may be the first sign of breast carcinoma; oral surgeons should be aware of this possibility.

show abstract

“…However, in our case, the patient was only 37 years old. Invasive ductal carcinoma is the most common form of breast cancer and accounts for 50-70% of invasive breast cancers [15]. Irani in 2016, in a review of 412 metastatic lesions that occurred in oral soft tissues, showed that gingiva was the most common site for metastases.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Carcinoma of the Breast Presenting as Gingival Swelling in the Maxilla: A Case Report

Sadasivan

Nambiar²,

Mathew

et al. 2022

Case Reports in Dentistry

View full text Add to dashboard Cite

Background. Metastatic cancers in the oral cavity are usually very rare and are usually an indication of widespread malignancy. In some cases, oral metastasis was found to be the first presentation of distant site tumours. Even though oral metastatic lesions may be found anywhere in the oral cavity, they commonly present in the posterior areas of the jaw bones. Among the soft tissues, the gingiva is the most common site. The presence of inflammation in the gingiva and the role of periodontal microbiota are suggested to play a role in the attraction of metastatic cells. The purpose of this case report is to present a rare case of metastatic breast carcinoma presenting as a gingival enlargement in the maxillary anterior region. Case Presentation. A 37-year-old female patient who underwent modified radical mastectomy for invasive ductal breast carcinoma reported to the dental clinic with a gingival enlargement in the anterior maxillary region. Clinical and radiographic examination showed a rapidly enlarging gingival lesion with destruction of the underlying bone. A wide excision of the entire lesion was done. Histopathological and immunohistochemical (IHC) evaluations were suggestive of infiltrating poorly differentiated adenocarcinoma. Conclusion. This case report presents a metastatic oral lesion in the maxillary anterior region of the primary breast cancer site. The young age of patient and an uncommon site of metastatic lesion are the striking features of this case. We would like to highlight the importance of a thorough clinical, radiological, and histological evaluation of any gingival swelling as it could be a metastatic lesion. IHC staining helps in the diagnosis of the primary site of metastatic carcinomas. An early diagnosis and intervention could reduce the morbidity of the lesion and improve the survival rate.

show abstract

Breast cancer metastasis to a mandibular extraction socket: A case report and discussion on clinical detection of metastasis to the oral cavity

Cited by 5 publications

References 22 publications

A Case Report on Mandibular Metastasis From a Breast Carcinoma

A Case Report on Mandibular Metastasis From a Breast Carcinoma

Breast carcinoma metastasis to the cheek: a case report

Metastatic Carcinoma of the Breast Presenting as Gingival Swelling in the Maxilla: A Case Report

Contact Info

Product

Resources

About