Breast carcinoma metastasis to the cheek: a case report

Miyazaki, Ryo; Kimoto, Natsuko; Okamoto, Satsuki; Tsuji, Asami; Nishigushi, Yusuke; Miyahara, Tomoya; Takahashi, Nobuhiro; Omata, Tetsuji

doi:10.1186/s13256-022-03326-6

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Our research strategy revealed a total of 88 relevant papers 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90…”

Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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Background Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date. Methods An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (“Breast cancer”, OR “Breast carcinoma”) AND (“Metastasis” OR “Metastases”), And (“Oral soft tissues” OR “Tongue” OR “Palate” OR “Tonsil” OR “Buccal mucosa” OR “Floor of mouth” OR “Vestibule” OR “Salivary glands”). We also searched all related journals manually. The reference list of all articles was also checked. Results Our research revealed 88 relevant papers (September 1967–September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months. Conclusions Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.

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Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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“…Metastasis can even appear in patients after a prolonged disease-free period [ 15 ]. Once the carcinoma spreads to the oral cavity, the presenting symptoms are numerous and varied, which include bleeding, swelling, loose tooth, numbness, trismus, foul-smelling breath, pathological fractures, ulceration, and lymphadenopathy [ 15 , 16 ]. A review of articles showed that numb chin syndrome (NCS) is also a sign of oral metastasis.…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Mandibular Metastasis From a Breast Carcinoma

Vetri¹,

Jacob²,

Kannichamy³

et al. 2022

Cureus

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Despite the rise in the number of cases of breast cancer in recent years, clinical diagnosis of a primary tumor in cases presenting with metastasis to the oral cavity poses a challenge in modern medicine because of its rare presentation.We report a case of breast cancer which presented as a painless swelling in the jaw. A 37-year-old multiparous woman consulted her dentist with complaints of toothache and swelling over the right cheek. On examination, she was diagnosed with dental caries and an orthopantomogram (OPG) was done to evaluate the swelling which revealed an area of rarefaction with an irregular margin on the right angle of the mandible. With suspicion of malignancy, the head, neck, oral and pharyngeal regions were thoroughly inspected and palpated. An ultrasonogram (USG) of the neck was done, which was normal and a core needle biopsy of the oral swelling was performed which showed metastatic carcinomatous deposits with pancytokeratin (PAN-CK) positivity, estrogen receptor (ER) positivity, and the Ki-67 value was 10% to 20% which was suggestive of breast carcinoma metastasis. Thereafter, the patient was referred for a surgeon's opinion. A breast examination was then done which revealed a lump in the right breast with a retracted nipple. A core needle biopsy of the lump revealed that it was ER and progesterone receptor (PR) positive and human epidermal growth factor receptor 2 (HER-2/neu) negative which confirmed the clinical diagnosis of breast cancer.Since the incidence of oral metastatic tumors is low, the likelihood of an early diagnosis of the distant primary tumor is reduced. Hence, all lesions of the oral cavity should be evaluated with due diligence considering the possibility of it being secondary metastases from distant tumors.

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“…Breast carcinoma is a common tumor in women, but it rarely metastasizes to the oral region; furthermore, metastases to the oral region occur mainly to the maxillary and mandibular bone and rarely to soft tissue 6–8 . We report metastatic tumor of the mandible on panoramic radiography and multidetector computed tomography (MDCT), especially a case report from the breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Panoramic radiography and computed tomography of metastatic breast carcinoma in the mandible: Report of a case

Ogura

Okada

Mizuhashi

et al. 2023

Oral Science International

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BackgroundBreast carcinoma is a common tumor in women, but it rarely metastasizes to the oral region.Case presentationAn 83‐year‐old woman presented with numbness and pain on the right side of the mandible. The patient's medical history included breast cancer that was treated with surgery. Panoramic radiograph showed a radiolucency with ill‐defined margin in the right mandible. CT images showed an osteolytic lesion with cortical bone destruction in the right mandible. Histopathological diagnosis was invasive ductal carcinoma.ConclusionDental practitioner should be aware that metastatic tumor of the mandible may occur in the patient with breast cancer.

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Breast carcinoma metastasis to the cheek: a case report

Cited by 5 publications

References 15 publications

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

A Case Report on Mandibular Metastasis From a Breast Carcinoma

Panoramic radiography and computed tomography of metastatic breast carcinoma in the mandible: Report of a case

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