Metastatic Carcinoma of the Breast Presenting as Gingival Swelling in the Maxilla: A Case Report

Sadasivan, Arun; Nambiar, K. Rakul; Mathew, Deepu George; Koshi, Elizabeth; Ramesh, Roshni; Benny, Ashna Mariya

doi:10.1155/2022/2667415

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Our research strategy revealed a total of 88 relevant papers 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90…”

Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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Background Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date. Methods An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (“Breast cancer”, OR “Breast carcinoma”) AND (“Metastasis” OR “Metastases”), And (“Oral soft tissues” OR “Tongue” OR “Palate” OR “Tonsil” OR “Buccal mucosa” OR “Floor of mouth” OR “Vestibule” OR “Salivary glands”). We also searched all related journals manually. The reference list of all articles was also checked. Results Our research revealed 88 relevant papers (September 1967–September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months. Conclusions Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.

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Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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“…Unconventional sites, such as the mandibular condyle or maxillary gingiva, can be colonized by the secondary spreading of primary cancer that can manifest with subtle or even without any symptoms [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer Cells Infiltration into a Mandibular Follicular Cyst

Marelli,

Ghizzoni,

Pellegrini

et al. 2023

Case Reports in Dentistry

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Introduction. The oral cavity is a rare site for other organs’ tumor metastases. The incidence rate ranges from 1% to 3% of all oral malignancies. Metastases more frequently localize in the mandible, especially in the molar area. Metastases within odontogenic cysts are extremely rare, thus in the literature, only a few cases have been reported. The follicular cyst is one of the most frequent cysts of the jaws. Radiologically it shows as a unilocular lesion with a sclerotic border, characterized by a homogenous radiolucency that incorporates the crown of the unerupted tooth. Methods. A 76-year-old female patient, affected by stage IV of lung adenocarcinoma, reported pain on the left mandible border, alongside lip dysesthesia. The ortho-panoramic radiograph showed a follicular cyst in the posterior left side of the mandible, with involvement of the ascending branch region. The cyst was surgically removed together with the impacted tooth. A histopathological examination of the specimen confirmed the diagnostic suspect of a follicular cyst, but in the cystic wall, focal infiltration of epithelial neoplastic cells was also found. The immunohistochemical analysis showed the presence of three different markers: CK 7+, TTF1+/−, and P40−. These markers identify the cells as metastatic lung carcinoma. Results. Secondary tumor spreading in the jaws’ area is rare (3% of all malignant lesions). Despite odontogenic cysts can undergo a dysplastic transformation (affecting the epithelial covering in ≤1% of the cases), infrequently these neoplastic cells can be related to secondary tumor spreading in a cystic wall. This report describes a metastatic localization within a mandibular follicular cyst. Conclusions. Malignant cancers’ metastasis in the oral district remains a rare and unexplored condition, especially when metastases are located in odontogenic cysts. In this circumstance, surgical removal and histopathological examination are strongly recommended.

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Development of a decision tree model for predicting the malignancy of localized gingival enlargements based on clinical characteristics

Sripodok,

Lapthanasupkul,

Arayapisit

et al. 2024

Sci Rep

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Metastatic Carcinoma of the Breast Presenting as Gingival Swelling in the Maxilla: A Case Report

Cited by 3 publications

References 33 publications

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Lung Cancer Cells Infiltration into a Mandibular Follicular Cyst

Development of a decision tree model for predicting the malignancy of localized gingival enlargements based on clinical characteristics

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