Breast cancer in brothersCase reports and a review of 30 cases of male breast cancer

Marger, Donald; Urdaneta, Nelson; Fischer, James J.

doi:10.1002/1097-0142(197508)36:2<458::aid-cncr2820360222>3.0.co;2-v

Cited by 29 publications

(9 citation statements)

References 11 publications

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“…Most authors found no association of prostatic cancer and breast cancer (Keller, 1967;Mabuchi et al, 1985;Schottenfeld et al, 1963). In contrast, in studies other than case-control studies, several investigators have mentioned a possible association between prostate cancer and male breast cancer (Choudhury et al, 1982;Marger et al, 1975;Schlappack et al, 1986;Sobin and Sherif, 1980). Sobin and Sherif (1980) found a worldwide correlation between the incidence of these 2 tumours, and this is confirmed in our data.…”

Section: Analytical Epidemiologysupporting

confidence: 85%

“…Although some authors state that lobular carcinoma cannot occur in men because male breasts do not contain lobules (Alagaratnam et al, 1981;Axelsson and Andersson, 1983;Meyskens et al, 1976;Ramantanis et al, 1980), several cases of lobular carcinoma have been reported (Bernheim et al, 1985;Sanchez et al, 1986;Tschahargane et al, 1985;Yogore and Sahgal, 1977). An estimated 1 to 5% of patients have bilateral tumours (Alagaratnam et al, 1981;Allain et al, 1988;Coley et al, 1971;Cordiano et al, 1971;Holleb et al, 1968;Marger et al, 1975;Moss, 1964;Peltokallio and Kalima, 1969;Ramantanis et at., 1980;Treves and Holleb, 1955;Von Magyar et al, 1982;Yap et al, 1979). Paget's disease, a known pre-malignant condition for women, also predisposes to male breast cancer (Gupta et al, 1983;Lancer and Moschella, 1982;Moshakis et al, 1983;Satiani etal., 1977).…”

Section: Dressedmentioning

confidence: 99%

“…Other reports are available of male breast-cancer patients with a father or brother with the same tumour (Marger et al, 1975), or of an excess risk of female breast cancer in the family (Ajayi et al, 1982;Everson et al, 1976;Kozak et al, 1986). -4 recent study (Hall et al, 1990) describes genetic analysis of 23 extended Caucasian families with 146 total cases of breast cancer.…”

Section: Analytical Epidemiologymentioning

confidence: 99%

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Review article: Epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors

Sasco

Lowenfels

Jong

1993

Intl Journal of Cancer

340

206

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Male breast cancer is a rare tumour in all parts of the world. About 1% of all breast cancers occur in men, but the male/female ratio is higher among black than among white populations. This effect can be seen in US cancer registries and even more markedly in African data. A positive correlation exists on a population scale between male breast cancer and prostate cancer. Seven case-control studies of male breast cancer are available, and a pooled analysis was conducted of the most commonly suspected risk factors. Male breast cancer appears to be associated with marital status: Mantel-Haenszel exposure odds ratio (EOR) for never married = 1.6; 95% confidence limits (CL) = 1.1, 2.3, religion (EOR for being Jewish = 2.1; 95% CL = 1.4, 3.2), previous breast pathology (EOR for positive history of benign breast disease = 2.7; 95% CL = 1.7, 4.2), gynaecomastia (EOR for positive history = 6.2, 95% CL = 3.4, 11.4), previous testicular pathology (EOR for positive history = 2.2; 95% CL = 1.5, 3.3), previous liver diseases (EOR for positive history = 1.6; 95% CL = 1.0, 2.4) and family history of breast cancer (EOR for first-degree relative with breast cancer = 2.5; 95% CL = 1.7, 3.7). No association is found with smoking history. Other potential risk factors such as reproductive history, education, occupation, anthropometric variables, association with various diseases, and specific exposures such as drug use, were not systematically evaluated in all studies and provide sometimes contradictory results, possibly due to small numbers of exposed subjects. Overall, the analytical epidemiology of male breast cancer presents similarities with the epidemiology of female breast cancer, with a potential role of factors related to hormonal status, relative hyperoestrogeny in men being potentially linked to increased risk of disease. Genetics may also play a role, with high risk linked to a familial history of breast cancer, and with a major risk in patients with Klinefelter's syndrome.

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Section: Analytical Epidemiologysupporting

confidence: 85%

Section: Dressedmentioning

confidence: 99%

Section: Analytical Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Review article: Epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors

Sasco

Lowenfels

Jong

1993

Intl Journal of Cancer

340

206

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“…Rare instances of families have been reported in which several men have developed breast carcinoma 12, 22–25. A higher incidence of breast carcinoma has been noted in Jewish males 26, 27.…”

Section: Discussionmentioning

confidence: 99%

Localized male breast carcinoma and family history

Hill¹,

Yağmur²,

Tran³

et al. 1999

Cancer

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BACKGROUND Male breast carcinoma is rare; therefore, the effect of family history on the course of the disease has not been well described. Germ‐line mutations in breast carcinoma susceptibility genes, particularly BRCA2, are associated with an increased risk of male breast carcinoma. The authors sought to correlate significant family history with clinical phenotype in males with breast carcinoma. METHODS One hundred forty‐two men with breast carcinoma were treated at Memorial Sloan‐Kettering Cancer Center or the Ochsner Clinic from 1973 to 1994. The authors reviewed the effect imparted by a family history of breast carcinoma on the duration of symptoms, the age at diagnosis, and the survival of men with this disease. RESULTS Fifteen percent of male breast carcinoma patients had a first‐degree relative with the disease. Fifty‐eight years was the mean age at diagnosis for those with a family history, compared with 61 years for those without (P = not significant [NS]). The mean duration of symptoms was 23 months for those with a family history, compared with 22 months for those without. Three of 22 patients (13.6%) with a family history, compared with 11 of 90 patients (12%) without a family history, had Stage III disease (P = NS) at presentation. The overall 5‐year and 10‐year survival rates were 86% and 64%. Survival was not affected by family history. Lymph node positivity reduced 5‐year and 10‐year survival rates to 73% and 50% (P = 0.0004). CONCLUSIONS For men with breast carcinoma, the presence of a family history did not affect the age at presentation, the duration of symptoms, the stage of disease at presentation, or the overall survival. In multivariate analysis, the most powerful predictor of outcome for these men was the status of the axillary lymph nodes. [See editorial on pages 744–6, this issue.] Cancer 1999;86:821–5. © 1999 American Cancer Society.

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“…Occupational exposure to heat and electromagnetic radiation, causing testicular damage and further leading to the development of MBC is also postulated [ 25 , 26 ]. An inherited predisposition for breast cancer is noticed in males-analogous to that in females [ 27 - 31 ]. A positive family history of a first-degree female relative having breast cancer is seen in up to 15–20% patients [ 32 ].…”

Section: Methodsmentioning

confidence: 99%